Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022672 (
acute tubular necrosis
)
2,175
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pediatric sepsis is a leading cause of morbidity and mortality in children. One of the most common and devastating morbidities is sepsis-related acute kidney injury (AKI). AKI was traditionally thought to be related to low perfusion and
acute tubular necrosis
. However, little
acute tubular necrosis
can be found following septic AKI, and little is known about the mechanism of septic AKI.
Olfactomedin-4
(
OLFM4
) is a secreted glycoprotein that marks a subset of neutrophils. Increased expression of
OLFM4
in the blood is associated with worse outcomes in sepsis. Here, we investigated a pediatric model of murine sepsis using murine pups to investigate the mechanisms of
OLFM4
in sepsis. When sepsis was induced in murine pups, survival was significantly increased in
OLFM4
-null pups. Immunohistochemistry at 24 h after the induction of sepsis demonstrated increased expression of
OLFM4
in the kidney, which was localized to the loop of Henle. Renal cell apoptosis and plasma creatinine were significantly increased in wild-type versus
OLFM4
-null pups. Finally, bone marrow transplant suggested that increased
OLFM4
in the kidney reflects local production rather than filtered from the plasma. These results demonstrate renal expression of
OLFM4
for the first time and suggest that a kidney-specific mechanism may contribute to survival differences in
OLFM4
-null animals.
...
PMID:Juvenile OLFM4-null mice are protected from sepsis. 3206 57
