Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022672 (
acute tubular necrosis
)
2,175
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Annexins are a family of eight highly conserved proteins that bind phospholipids in the presence of calcium. One of these proteins,
lipocortin I
, has restricted distribution in adult and developing tissues, suggesting regulatory function. Among the protean roles theorized are regulation of inflammation by influencing eicosanoid production, participation in endo- and exocytosis, and control of membrane permeability. Such processes could have important roles in the inner ear; therefore, we investigated the patterns of
lipocortin I
expression in the normal guinea pig ear.
Lipocortin I
appeared at high levels in nonsensory, endolymph-facing tissues. Perilymph-facing cells had little
lipocortin I
activity.
Lipocortin I
was minimally expressed, or is absent, in sensory cells of the cochlea and vestibular systems. In the kidney, changes in quantity and distribution of
lipocortin I
have been seen during recovery from
acute tubular necrosis
. In an attempt to gain insight into the role of
lipocortin I
, the authors investigated its response to an experimental insult. Surgically created endolymphatic hydrops was chosen as an insult involving the endolymph-producing epithelia that richly express
lipocortin I
. Comparing unilaterally created hydrops, for up to 3 weeks' duration, to contralateral control ears demonstrated no quantitative or distribution changes in
lipocortin I
.
...
PMID:Lipocortin I immunolocalization in normal and hydropic guinea pig ears. 858 6
