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Query: UMLS:C0022672 (
acute tubular necrosis
)
2,175
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of administering
insulin-like growth factor I
(
IGF-I
) were examined in a model of ischemic
acute tubular necrosis
in rats. Injury was induced by 75 min of bilateral renal artery occlusion. Compared to rats administered vehicle, rats administered
IGF-I
(100 micrograms/day via continuous subcutaneous infusion) had significantly lower serum creatinine and blood urea nitrogen levels over the course of 7 days postocclusion. Glomerular filtration rate as determined by inulin clearance was examined on day 2 postocclusion and was significantly increased in
IGF-I
-treated animals (0.16 +/- 0.02 ml per min per 100 g of body weight) compared to vehicle-treated controls (0.08 +/- 0.02 ml per min per 100 g of body weight). The weight loss that occurred during the course of
acute tubular necrosis
was ameliorated by
IGF-I
. Mortality was reduced from 36.7% in vehicle-treated rats to 7.1% in rats administered
IGF-I
. Histologically, there was much less renal injury evident at day 7 postocclusion in the
IGF-I
-treated rats compared to vehicle-treated controls. In contrast, growth hormone (200 micrograms administered subcutaneously for 4 days) did not affect recovery of renal function or reduce mortality postreperfusion. This report demonstrates a beneficial effect of
IGF-I
administration in the setting of
acute tubular necrosis
. Several properties of
IGF-I
render it a pharmacological agent with excellent potential for treatment of this condition in humans.
...
PMID:Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat. 146 11
