Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022672 (
acute tubular necrosis
)
2,175
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It is now clearly established that anti-vascular endothelial growth factor (VEGF) drug class induces hypertension and proteinuria sometimes related to thrombotic microangiopathy and/or various glomerulopathies, according to capillary and glomerular VEGF and VEGF-receptor expressions. As reported in the literature, anti-
epidermal growth factor receptor
(
EGFR
) therapies seem to be less nephrotoxic. Indeed, many reports of anti-
EGFR
nephrotoxicity are tubular dependent such as
acute tubular necrosis
, electrolyte disorders (hypophosphatemia, hypomagnesemia, etc.) or both. This is explained by elective tubular expression of renal EGF/
EGFR
. In this paper, we focus on electrolyte disorders related to anti-
EGFR
treatment and discuss the tubular involvement of these drugs based on their renal expression.
...
PMID:Electrolyte disorders related to EGFR-targeting drugs. 1940 15
