Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
Compound
Query: UMLS:C0022672 (
acute tubular necrosis
)
2,175
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Perchloroethylene
(
PCE
) is an unsaturated chlorinated hydrocarbon in the form of a colorless, volatile liquid that is used as an industrial organic solvent for metal degreasing and for dry cleaning. The majority of cases of
PCE
intoxication have occurred by chronic inhalation, and
PCE
has been implicated previously in the development of mild renal dysfunction. However, the acute effects of
PCE
on the kidney are not well characterized, and the authors know of no reports of renal biopsy findings in the human. Here the case of a 32-year-old man who manifested by semicomatose state and oliguric acute renal failure requiring dialysis after accidental ingestion of 75 g of
PCE
is presented. A renal biopsy performed on the 19th day after ingestion showed features characteristic of severe
acute tubular necrosis
: aggregations of triangular or rhomboid crystals in the tubular lumens. A von Kossa stain showed that the crystal deposits were strongly positive for calcium. After 5 hemodialyses and conservative treatment, renal function gradually returned to normal.
...
PMID:ARF requiring hemodialysis after accidental perchloroethylene ingestion. 1261 4
