Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022672 (acute tubular necrosis)
 2,175 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients with renal disease are at risk of further deterioration of renal function and acute tubular necrosis when subjected to anaesthesia and surgery. Optimal fluid loading and careful selection of anaesthetic techniques and agents, appropriate monitoring and the use of mannitol and dopamine assist in the maintenance of renal blood flow and help preserve renal function in these patients. In association with renal failure, physiological changes in other systems result in reduced oxygen supply to the tissues, metabolic disturbances, impairment of the coagulation and immune defence mechanisms and an increased risk of cardiac and cerebrovascular catastrophe. Although many anaesthetic techniques including regional analgesia may be used successfully in these patients caution with most drugs, especially pethidine, phenoperidine, suxamethonium and all non-depolarising neuromuscular relaxants is recommended. Of the volatile anaesthetics currently available, halothane is the agent of choice. Oxygen therapy and close monitoring of cardiorespiratory function are necessary postoperatively.
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PMID:Anaesthesia for the patient with impaired renal function. 635 49

To analyze the clinical management of the renal transplant recipient from a kidney living donor. The renal transplantation (RT) from a living donor without surgical complications has a very low frequency of acute tubular necrosis (ATN) that facilitates enormously the clinical control. The scheme of follow-up after-RT must include: (1) Hemodynamic monitoring; (2) Clinical management; (3) Renal allograft monitoring: renal function, diuresis, radionuclide imaging and ultrasound-Doppler; (4) Pharmacological treatment: analgesia, gastric protection, antibiotic prevention; (5) Monitoring of the immunosuppressive therapy; (6) Digestive monitoring; (7) Control of the cardiovascular risk; (8) Preventions infectious; (9) Osteodistrophia control. In living donor RT a rapid normalization of the renal function and a time of hospitalization reduced are observed. The presence of a long ATN or a renal dysfunction of the graft must force to realize an early renal allograft biopsy.
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PMID:[Clinical management of the living donor kidney transplant recipient]. 1613 65