Gene/Protein
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Drug
Enzyme
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Pivot Concepts:
Gene/Protein
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Drug
Enzyme
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Target Concepts:
Gene/Protein
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Query: UMLS:C0022672 (
acute tubular necrosis
)
2,175
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Reports of the incidence of acute kidney injury (AKI) in patients with COVID-19 have varied greatly from 0.5% to as high as 39%, with onset generally within 7 days from time of admission
1
. The nature of the kidney insult is
acute tubular necrosis
, immune cell infiltration or rhabdomyolysis as demonstrated in autopsy reports
2
,
3
. Moreover, infection with COVID-19 has been associated with coagulation abnormalities
4
, as well as complement-mediated generalized thrombotic microvascular injury
5
. These patients have been found to have high D-dimer, fibrin degradation product and fibrinogen values, an elevated INR, normal PTT and normal platelet counts.
Renal artery thrombosis
is a rare condition, the most common cause of which is atrial fibrillation. However, bilateral completely occlusive renal artery thrombosis is even rarer. We present a case of a patient with COVID-19 on systemic anticoagulation who presented with a serum creatinine of 6.04mg/dL requiring the initiation of kidney replacement therapy and was found to have bilateral renal artery thrombosis.
...
PMID:Bilateral Renal Artery Thrombosis in a Patient With COVID-19. 3320 Jan 22
