Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022672 (acute tubular necrosis)
 2,175 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The control of the massive and often fatal hemorrhage from pelvic neoplasms is a major therapeutic problem. Transcatheter embolization of the internal iliac arteries was performed in 108 patients with uncontrollable hemorrhage due to pelvic neoplasms (urinary bladder in 50, uterus in 39, ovary in 16, and prostate in three). Complete control of the hemorrhage was achieved in 74 patients, partial control in 23, and no control in 11. Seventy patients experienced postembolization syndrome (nausea, vomiting, gluteal pain, and fever due to tissue necrosis), and three had transient acute tubular necrosis caused by the contrast medium. It is important for success that the embolization be bilateral and that the embolic agent used be a permanent one.
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PMID:Internal iliac artery: embolization to control hemorrhage from pelvic neoplasms. 274 11

a 17-year-old gravida 1, para 0, single white girl who had undergone criminal abortion, presented at the hospital with high fever and red urine. Her vital signs were monitored and laboratory tests were performed. A total abdominal hysterectomy and salpingo-oophorectomy were performed because of gangrenous uterus and ovaries. The patient developed postoperative complications and blood transfusion was performed. The criminal abortion was induced using some type of liquid (eg., Lysol) that was injected into the uterus transvaginally. The use of Lysol, soap and detergents in criminal abortion produces an area of tissue necrosis. The compounds are also absorbed into the bloodstream. The necrotic tissue is susceptible to infection, while the part which is absorbed into the bloodstream is nephrotoxic, hepatotoxic and produces hemolysis. Common complications of septic abortion are pelvic abscesses; metastatic abscesses; tetanus; renal insufficiency; cortical necrosis; and acute tubular necrosis. Coagulation abnormalities, as well as the psychological, economic and legal aspects of septic abortion are also discussed. It is hoped that all physicians would actively support legislation which would liberalize abortion laws.
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PMID:Medical grand rounds at Yale-New Haven Hospital. Septic abortion. 550 61

LHRH-PE40, a recombinant DNA-derived protein composed of LHRH and Pseudomonas aeruginosa exotoxin A, is being developed for the treatment of malignant tumours. This experiment was designed to assess its preclinical safety. Reproductive toxicity studies, pharmacokinetic studies, single- and repeat-dose intraperitoneal or intravenous toxicity studies in mice, rats and monkeys were conducted to assess the toxicity of LHRH-PE40. In intravenous single-dose studies in mice, the LD50 was 731.26 microg/kg and 676.03 microg/kg in male and female mice respectively. In single-dose studies and repeat-dose range-finding studies in rats, dose-limited severe vascular leakage syndromes occurred. In repeat-dose long-term studies, except drug-related vascular leakage syndromes, other drug-related changes included decreased testis weight and testis atrophy. In single-dose and repeat-dose studies in monkeys, dose-limited acute tubular necrosis of the kidneys was the chief finding. In reproductive studies, drug-related changes were decreased food intakes, decreased testis weight and uterus weight, decreased foetus weight and increased foetus mortality, increased maternal and F1 offspring mortality and decreased maternal and F1 offspring body weight. Pharmacokinetic studies showed a similar half-time of distribution and clearance in mice and monkeys. Tissue distribution showed a high concentration in the kidneys and a low concentration in the brain. LHRH-PE40 induced vascular leak syndromes in rats and acute tubular necrosis in monkeys. It also led to testicle atrophy in rats and overt productive toxicity to parents and F1 generations in mice. Because of these findings, it should be monitored carefully in human clinical trials for things such as respiratory, urinary and reproductive toxicities.
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PMID:A recombinant protein LHRH-PE40 for tumour therapy: preclinical safety studies. 1716 19

A 51-year-old woman with adenomyosis was admitted because of anemia with schistocytosis, thrombocytopenia, and acute renal failure (ARF). Thrombotic microangiopathy (TMA) was considered. Plasma exchange and steroid therapies improved laboratory results. However, renal biopsy specimen revealed acute tubular necrosis (ATN), but not TMA, and thrombocytopenia, diagnosed it as disseminated intravascular coagulation (DIC) but not TMA. Few cases of DIC associated with benign tumors of the uterus and, especially, adenomyosis have been reported. In adenomyosis patients, ARF is usually caused by obstructive uropathy. However, the rare case suggests that hemolytic anemia, DIC, and ARF due to ATN can occur in adenomyosis patients.
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PMID:A case of anemia with schistocytosis, thrombocytopenia, and acute renal failure caused by adenomyosis. 2200 63