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Query: UMLS:C0022672 (acute tubular necrosis)
 2,175 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Crush syndrome is characterized by a predictable sequence of events that include hypovolemia, compartment syndrome, rhabdomyolysis and acute tubular necrosis (ATN). Cardiac dysrhythmias are common. Pathophysiology, current management, and a plan of nursing care for patients with crush syndrome are presented.
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PMID:Crush syndrome: pathophysiology and management. 227 45

Rhabdomyolysis is the disintegration of striated muscles resulting in the release of muscular cell contents into the extracellular fluid. Crush syndrome is systemic manifestations caused by rhabdomyolysis; the most important component of crush syndrome is acute kidney injury. Non-physical and physical causes play a role in the aetiology of rhabdomyolysis. Clinical spectrum varies from asymptomatic elevation in creatine kinase to acute tubular necrosis and multiorgan failure. Myoglobinuria, increased serum creatine kinase level and hyperkalaemia are the most important laboratory parameters. Vigorous hydration with isotonic saline followed by alkaline solutions and mannitol are useful in the treatment of rhabdomyolysis.
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PMID:Rhabdomyolysis. 1828 3