Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022575 (keratoconjunctivitis sicca)
 772 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
lacrimal 126
HRD 82
Sep 48
SS-A 36
SS-B 32
rheumatoid factor 31
lactoferrin 21
lysozyme 19
SSA 17
mucin 16
SSB 16
interferon 15
IgA 14
lamp 14
lymphoid 13
She 12
cytokine 10
long chain 9
HLA 9
collagen 8
Rec 8
LL) 7
Fas 6
PKR 6
NOD 5
ANA 5
fibronectin 5
Mol 5
CD4 5
AQP5 4
epidermal growth factor 4
IL-6 4
insulin 4
Rheumatoid factor 4
IFN 4
Cytokine 4
TNF 3
p68 kinase 3
p48 3
HLA-DR 3
all-trans 3
CD25 3
bcl-2 3
amylase 3
MUC5AC 3
MRI 3
STAT1 3
ribonucleoprotein 3
lectin 3
CD8 3
RNP 3
HLA-DR4 3
granzyme A 2
adenosine deaminase 2
glycoprotein 2
TSP 2
chronic renal failure 2
tumor necrosis factor 2
prealbumin 2
Fas ligand 2
cytokeratin 2
STAT2 2
Sp1 2
APO-1 2
chemokine 2
ERK 2
DES 2
HLA-DR3 2
SDS 2
endoplasmic reticulum 2
bax 2
olfactory 2
reserved 2
alpha-fodrin 2
lipase 2
membrane-bound 2
peroxidase 2
B10 2
ACTH 2
perforin 2
polypeptide 2
MMP-9 2
HLA-B27 2
ARA 2
class II antigen 2
caspase-3 2
alternatively spliced 2
interferon-inducible 2
ADAR1 2
DR4 2
GABA 1
fibrinogen 1
MIP-1alpha 1
Ro60 1
tumor necrosis factor alpha 1
enigma 1
gut 1
lamin A/C 1
NOV 1
OCT 1
carbonic anhydrase VI 1
thymus 1
ankylosing spondylitis 1
CASP 1
ITSN2 1
adenyl cyclase 1
Protein kinase 1
PI3K 1
Bcl-2 1
transthyretin 1
San 1
ASA 1
JAK1 1
CCP 1
transcription factor Sp1 1
HCD 1
Boc 1
intercellular adhesion molecule 1 1
EPA 1
TBM 1
dopamine D2 receptor 1
Growth hormone 1
TCR 1
HST 1
protease inhibitor 1
core protein 1
nerve growth factor 1
phosphoinositide 3-kinase 1
heavy chain 1
cytochrome c 1
cysteine-rich secretory protein 3 1
cyclic nucleotide phosphodiesterase 1
Ro52 1
pseudoxanthoma elasticum 1
secretin 1
glucocorticoid receptor 1
beta-tubulin 1
B12 1
hepatocyte growth factor 1
sensitive to apoptosis gene 1
KRAS 1
interleukin 2 receptor 1
CRB 1
TBCE 1
MAR 1
DDB1 1
E-selectin 1
SAH 1
FIB 1
p42 1
beta 1 1
TIMP 1
beta-2-microglobulin 1
adenylyl cyclase 1
EST 1
CIE 1
MEK 1
HLA B44 1
IL-22 1
NHS 1
fused 1
Cyr61 1
histone deacetylase 1
PTH 1
MSC 1
rapa 1
ACID 1
parathyroid hormone 1
human leucocyte antigen 1
alpha-tubulin 1
NF-IL6 1
heterogeneous nuclear ribonucleoprotein A1 1
DGK-theta 1
PRDM1 1
FAM83H 1
tricellulin 1
p65 1
CO2 1
carbonic anhydrase 1
DDX6 1
glutamic acid decarboxylase 1
autoantigen 1
wich 1
DQw 1
U1-70K 1
Metalloproteinase 1
STAT4 1
castor 1
FSH 1
PER 1
neuraminidase 1
PVA 1
CCL4 1
CTR1 1
HSF 1
PAL 1
CAD 1
Mucin 1
ERK1 1
parotid secretory protein 1
mouse homolog 1
cytokeratin 14 1
hinge 1
ADM 1
p150 1
TNFAIP3 1
microsomal 1
p44 1
FK506 1
calmodulin 1
UTR 1
IL-17 1
NADPH 1
non-Hodgkin's lymphoma 1
CYP 1
SATB1 1
IRF9 1
JNK 1
interferon-alpha 1
interferon alpha 1
PHIP 1
K10 1
B-5 1
DM1 1
IL-1 1
TNPO3 1
TNIP1 1
ESR 1
Men 1
interleukin-17 1
aquaporin 1
DNA-binding protein 1
creatine kinase 1
CD14 1
purinergic receptor 1
S100 1
BSS 1
caspase-9 1
Pol 1
ISGF-3 1
HLA-D 1
LCD 1
alanine aminotransferase 1
GRP78 1
IGF-I 1
SGB 1
FCGR2A 1
superoxide dismutase 1
IGF-1 1
histidyl-tRNA synthetase 1
2',5'-oligoadenylate synthetase 1
LIP1 1
C30 1
DR3 1
GPAT 1
forkhead box P3 1
urokinase-type plasminogen activator 1
FAM167A 1
STD 1
p46 1
CREST 1
BLK 1
TNF receptor 1
vasoactive intestinal peptide 1
CXCR5 1
extracellular signal-regulated kinase 1
DDB2 1
ATP-binding cassette 1
BCAN 1
ERF 1
C18 1
TAG-1 1
FAG 1
thrombospondin 1
p38 mitogen-activated protein kinase 1
CD57 1
SAG 1
DBA 1
SGS 1
IFN-gamma 1
Pseudomonas 1
ROC2 1
IL-1 alpha 1
RNP antigen 1
TNF-alpha 1
prolactin receptor 1
ADP 1
vascular cell adhesion molecule-1 1
2-5A synthetase 1
interferon-gamma 1
Id3 1
MMP-2 1
cytochrome P450 1
P2Y2 1
MHC 1
SIMPL 1
extracellular signal-regulated kinase 1 1
LIV-1 1
caspase-8 1
Nrf2 1
CUT 1
CD1 1
cystatin C 1
acetylcholinesterase 1
ubiquitin 1
thyroglobulin 1
EGF 1
tRNA 1
kappa light chain variable region 1
Albumin 1
MYB 1
growth hormone 1
CBS 1
HDL 1
La protein 1
threonyl-tRNA synthetase 1
FHOD1 1
Hey2 1
glutamate decarboxylase 1
Gal 1
IFNAR 1
Human leukocyte antigen 1
autoimmune regulator 1
MIP-1beta 1
Nei 1
CD19 1
aniridia 1
ABCB1 1
type I interferon 1
S100A7 1
PTTG1 1
methyltransferase 1
DQw3 1
RNA polymerase I 1
CAL 1
UND 1
CHD7 1
P38 1
Ig-alpha 1
CER1 1
alanyl-tRNA synthetase 1
adhesion molecule 1
vasopressin 1
reductase 1
Ban 1
IL12A 1
IRF5 1
renal amyloidosis 1
PSP 1
human leukocyte antigen 1
beta-endorphin 1
SCT 1
CRL 1
cystic fibrosis transmembrane conductance regulator 1
adrenocorticotropic hormone 1
lipid transfer protein 1
IVA 1
JAMA 1
CTGF 1
Disease
keratoconjunctivitis sicca 772
xerostomia 158
KCS 82
autoimmune disease 77
cornea 59
rheumatoid arthritis 56
conjunctiva 43
systemic lupus erythematosus 41
conjunctivitis 36
keratitis 34
arthritis 34
vasculitis 32
Sjogren's syndrome 26
uveitis 25
sialadenitis 23
cataract 22
graft-versus-host disease 22
glaucoma 19
tumor 18
blepharitis 18
dry eye syndrome 18
connective tissue disease 17
PSS 17
lymphoma 17
scleroderma 16
keratopathy 16
cancer 15
keratoconjunctivitis 15
systemic disease 14
Cornea 14
neuropathy 14
Cornea 14
scleritis 14
anterior uveitis 14
epiphora 13
pemphigoid 13
corneal ulcer 13
lupus 13
Raynaud's phenomenon 13
Stevens-Johnson syndrome 12
episcleritis 12
eye disease 12
sarcoidosis 11
xerophthalmia 11
lymphadenopathy 10
lupus 10
prolapse 9
primary biliary cirrhosis 9
immunodeficiency 9
sicca syndrome 9
diabetes 8
amyloidosis 8
blindness 8
HIV 7
optic neuritis 7
anemia 7
dermatitis 6
pruritus 6
hypothyroidism 6
rosacea 6
hypergammaglobulinemia 6
intraocular pressure 6
interstitial pneumonia 6
parotitis 6
polymyositis 5
fibromyalgia 5
iridocyclitis 5
hepatitis 5
pancreatitis 5
dacryocystitis 5
trichiasis 5
dental caries 5
osteoarthritis 5
NOD 5
autonomic neuropathy 5
proptosis 5
multiple sclerosis 5
dacryoadenitis 5
iritis 4
infectious conjunctivitis 4
renal disease 4
blepharoconjunctivitis 4
psoriasis 4
leukemia 4
B-cell lymphoma 4
hepatitis C 4
arthropathy 4
ulcerative colitis 4
thrombocytopenia 4
nephritis 4
juvenile rheumatoid arthritis 4
allergic conjunctivitis 4
interstitial nephritis 4
renal tubular acidosis 4
Epstein 4
pleurisy 4
Syndrome 4
lagophthalmos 4
atopic dermatitis 4
rash 4
pneumonia 4
glomerulonephritis 4
pulmonary fibrosis 4
entropion 4
ischemia 3
peripheral neuropathy 3
mononeuritis 3
autoimmune thyroiditis 3
proteinuria 3
myopathy 3
polyneuropathy 3
cholestasis 3
otitis media 3
dysplasia 3
myositis 3
asthma 3
peritonitis 3
SEM 3
Orbit 3
Primary Sjogren's syndrome 3
Parotid enlargement 3
chronic hepatitis 3
colitis 3
hemolytic anemia 3
lymphoproliferative disorders 3
herpes 3
herpes simplex 3
retinopathy 3
nephrotic syndrome 3
bronchiolitis 3
Hodgkin's disease 3
SLE 3
leishmaniasis 3
xanthoma 3
cystic fibrosis 3
atrophic gastritis 3
xerosis 3
ischemic optic neuropathy 3
carcinoma 3
AIDS 3
polyarthritis 3
adult T-cell leukemia/lymphoma 3
erythroderma 3
HAM 3
vascular disease 3
Lip 3
EBV infection 3
skin disease 3
chronic conjunctivitis 3
lichen planus 3
virus infection 3
stomatitis 3
interstitial lung disease 3
Anterior 3
mixed connective tissue disease 3
psoriatic arthritis 3
parvovirus 2
multiple myeloma 2
onychogryphosis 2
cholangitis 2
liver disease 2
mental retardation 2
migraine 2
chronic renal failure 2
Conjunctiva 2
periodontitis 2
epilepsy 2
Raynaud 2
choroiditis 2
renal failure 2
astigmatism 2
lupus nephritis 2
confusion 2
infectious diseases 2
lymphocytosis 2
retinitis 2
SDS 2
retinal detachment 2
keratoconus 2
herpes zoster 2
rheumatism 2
macroglobulinemia 2
thyroiditis 2
neurological disease 2
dementia 2
corneal edema 2
coronary artery disease 2
rubella 2
Submandibular gland 2
neutropenia 2
Conjunctiva 2
nystagmus 2
cytomegalovirus 2
Kenny-Caffey syndrome 2
polyarthralgia 2
hyperparathyroidism 2
incontinence 2
dysphagia 2
sickle cell disease 2
bacterial infection 2
sclera 2
esophageal stricture 2
hyperproteinemia 2
acute pancreatitis 2
plaque 2
aqueous humor 2
synovitis 2
hypoparathyroidism 2
endophthalmitis 2
uvea 2
aphthous stomatitis 2
aplastic anemia 2
Peripheral ulcerative keratitis 2
interstitial keratitis 2
vagina 2
myasthenia 2
ectropion 2
osteosclerosis 2
Superior limbic keratoconjunctivitis 2
squamous cell carcinoma 2
DES 2
Infection 2
Poland 2
Chronic GVHD 2
CREST 2
chronic pancreatitis 2
diplopia 2
meningoencephalomyelitis 2
HLA-B27 2
meibomitis 2
West 2
vitamin A deficiency 2
mental retardation 2
myelopathy 2
Mikulicz 2
meningitis 2
dysautonomia 2
facial palsy 2
vitiligo 2
renal insufficiency 1
telangiectasia 1
pemphigus 1
fasciitis 1
stroke 1
Leber's hereditary optic neuropathy 1
scleromalacia 1
peptic ulcer 1
hay fever 1
adrenal hyperplasia 1
Facial nerve paresis 1
infestation 1
staphylococcus 1
Chlamydia 1
heart block 1
heart failure 1
Toxic epidermal necrolysis 1
Retinal vasculitis 1
giant cell arteritis 1
muscular dystrophy 1
SLE with diffuse proliferative glomerulonephritis 1
Best 1
polyarteritis nodosa 1
gallstones 1
pericarditis 1
gammopathy 1
heavy chain disease 1
Familial amyloid polyneuropathy 1
lung disease 1
eyelid dermatitis 1
chorioretinitis 1
Aqueous tear deficiency 1
choroidopathy 1
myocarditis 1
pseudoxanthoma elasticum 1
sensory neuropathy 1
renal papillary necrosis 1
Lupus 1
myopia 1
pulmonic stenosis 1
Cushing's disease 1
invasive thymoma 1
Goldenhar syndrome 1
periodontal disease 1
DM1 1
anhidrosis 1
purpura 1
medullary thyroid carcinoma 1
cleft palate 1
hepatitis B 1
renal impairment 1
plateau iris 1
lymphadenitis 1
Nelson 1
PAL 1
genetic disorder 1
Lymphocytic infiltration 1
metastases 1
anisometropia 1
FFM 1
bilateral cataracts 1
proctalgia fugax 1
congenital disorder 1
hyperkeratosis 1
Fungal keratitis 1
petechiae 1
respiratory failure 1
EBMD 1
Necrotizing conjunctivitis 1
non-Hodgkin's lymphoma 1
DBA 1
pancreatic insufficiency 1
bronchiectasis 1
ocular herpes 1
cold 1
breast cancer 1
multiple endocrine neoplasia 1
Chronic blepharitis 1
Annular erythema 1
Schistosoma mansoni 1
arthrodesis 1
retinal vascular occlusion 1
bronchitis 1
thymoma 1
bacterial conjunctivitis 1
macular degeneration 1
Herpesvirus infection 1
retinopathy of prematurity 1
pernicious anemia 1
encephalitis 1
panniculitis 1
hypertensive retinopathy 1
Li-Fraumeni syndrome 1
SCT 1
pheochromocytoma 1
pancreatic cancer 1
Atrophic 1
phlebitis 1
rhinitis 1
retinitis pigmentosa 1
pancytopenia 1
nephrocalcinosis 1
Fox 1
azotemia 1
autoimmune hemolytic anemia 1
malabsorption 1
calcinosis 1
coxsackievirus 1
dysphonia 1
erythema multiforme 1
Soft palate 1
Multiple chemical sensitivity 1
HTLV-I 1
gastric cancer 1
sialolithiasis 1
hydronephrosis 1
Papillary conjunctivitis 1
panophthalmitis 1
mononeuropathy 1
Cushing's syndrome 1
oral candidiasis 1
suicide 1
cutis laxa 1
Crohn's disease 1
erythema nodosum 1
cryoglobulinemia 1
pyoderma gangrenosum 1
progressive supranuclear palsy 1
anemia of chronic disease 1
Cannabis 1
cyclitis 1
Bladder 1
panuveitis 1
IVA 1
hypercholesterolemia 1
myeloid leukemia 1
hyperlipidemia 1
gastritis 1
AL amyloidosis 1
Distal renal tubular acidosis 1
gastroesophageal reflux disease 1
cycloplegia 1
hypernatremia 1
deafness 1
Schistosoma japonicum 1
achalasia 1
HIV retinopathy 1
dehydration 1
SGS 1
hyperphagia 1
mastitis 1
PSP 1
hypertension 1
polyclonal hypergammaglobulinemia 1
epididymis 1
localized scleroderma 1
urticaria 1
IOL 1
hyperthyroidism 1
steatorrhea 1
ectodermal dysplasia 1
caruncle 1
MAR 1
sacroiliitis 1
xanthogranuloma 1
ARF 1
Graves' ophthalmopathy 1
depression 1
adenocarcinoma 1
measles 1
seborrheic dermatitis 1
thyroid cancer 1
histiocytoma 1
esophagitis 1
mimicry 1
dermatophytosis 1
giardiasis 1
PER 1
NHS 1
renal cell carcinoma 1
superficial keratitis 1
diabetes insipidus 1
exotropia 1
type 1 diabetes 1
osteomyelitis 1
pinguecula 1
Mooren's ulcer 1
poikiloderma 1
osteoporosis 1
hypercortisolism 1
rare disease 1
Haemophilus 1
sclerodactyly 1
mental illness 1
dilated cardiomyopathy 1
STD 1
melanoma 1
diabetic ketoacidosis 1
sclerokeratitis 1
SGS 1
Behcet's disease 1
thrombocytopenic purpura 1
esophageal web 1
toxoplasmosis 1
PCC 1
lichen 1
Still's disease 1
sarcoma 1
orbital cellulitis 1
CHARGE syndrome 1
biliary colic 1
bronchitis 1
carpal tunnel syndrome 1
residual disease 1
IgA nephropathy 1
ocular toxoplasmosis 1
disabling disease 1
Plaque 1
polyradiculoneuropathy 1
inflammatory bowel disease 1
immune deficiency 1
cellulitis 1
tumorigenesis 1
disc degeneration 1
other autoimmune disease 1
chronic liver disease 1
skin ulcers 1
celiac disease 1
periosteum 1
EIN 1
inflamed eye 1
Alzheimer's disease 1
trachoma 1
DRS 1
Bernard-Soulier syndrome 1
vitamin B12 deficiency 1
Acute anterior uveitis 1
Facial palsy 1
vitamin D deficiency 1
duodenitis 1
memory impairment 1
Diffuse scleritis 1
gout 1
CIE 1
Bladder 1
obstructive jaundice 1
spondylitis 1
ankylosing spondylitis 1
Posterior 1
ectopic pregnancy 1
Whipple's disease 1
lipidosis 1
MCF 1
dyskinesia 1
HRD 1
Urbach 1
Graves' disease 1
primary sclerosing cholangitis 1
Bladder 1
molluscum contagiosum 1
morphea 1
Posterior scleritis 1
bipolar disorder 1
lymphatic vessels 1
Symptom
dry eye 123
discomfort 21
discomfort 21
pain 16
fatigue 13
thinning 8
photophobia 6
seizures 6
anesthesia 6
sialectasis 5
blepharospasm 5
arthralgia 4
myalgia 4
blurred vision 3
splenomegaly 3
erythema 3
weakness 3
agitation 2
numbness 2
cough 2
diarrhea 2
dysesthesia 2
eye pain 2
dyspnea 2
vomiting 2
Kayser-Fleischer ring 1
spasm 1
finger pain 1
DNA marker 1
back pain 1
livedo 1
dystonia 1
partial seizure 1
polymyalgia 1
overweight 1
dizziness 1
eye discharge 1
angina 1
polyuria 1
hoarseness 1
fasciculation 1
sciatica 1
enuresis 1
adenitis 1
aniseikonia 1
tingling 1
functional recovery 1
shortness of breath 1
abdominal discomfort 1
headache 1
abdominal pain 1
hemoptysis 1
colic 1
epigastric pain 1
Drug
Dermatol 4
Fluorescein 3
Fluorescein 3
Pilocarpine 2
Prednisolone 2
Asthma 2
Sodium hyaluronate 2
ascorbate 2
Rituximab 2
Retinoic Acid 1
Sucralfate 1
Citric acid 1
Growth hormone 1
Ketoconazole 1
lysine 1
IFN-gamma 1
Tuberculin 1
Albumin 1
CTX 1
Cellulose acetate 1
Methylcellulose 1
Forskolin 1
Growth hormone 1
Tacrolimus 1
Vitamin A 1
Ketalar 1
Prednisone 1
uPA 1
PTH 1
Secretin 1
Retinoic acid 1
Solcoseryl 1
ADM 1
ROC 1
MgSO4 1
DM1 1
NOV 1
KCL 1
Enzyme
lysozyme 19
protein kinase 7
fatty acid elongase 5
acyl-CoA synthetase 5
TSP-1 3
focal adhesion kinase 3
mitogen-activated protein kinase 3
lipase 2
caspase-3 2
estrogen sulfotransferase 2
adenosine deaminase 2
ribonuclease 2
chloramphenicol acetyltransferase 2
peroxidase 2
ribonuclease 2
RNase 2
RNase 2
adenosine deaminase 2
ERK 2
alanyl-tRNA synthetase 1
urokinase-type plasminogen activator 1
neuraminidase 1
CAD 1
4CL 1
phosphoinositide 3-kinase 1
citrate synthase 1
ACE 1
fatty acyl-CoA reductase 1
PAL 1
ascorbate peroxidase 1
histidyl-tRNA synthetase 1
MEK 1
condensing enzyme 1
PDE 1
superoxide dismutase 1
glutamate decarboxylase 1
RNA polymerase 1
fatty-acyl-CoA synthase 1
elastase 1
adenylate cyclase 1
reverse transcriptase 1
CAD 1
PAL 1
CAD 1
TRS 1
alanine aminotransferase 1
glycerophosphate acyltransferase 1
trypsin 1
creatine kinase 1
carbonic anhydrase 1
plasmin 1
Compound
Clin 70
Dec 39
sodium 22
DNA 17
Rose Bengal 13
water 12
sulfate 8
hyaluronic acid 6
retinoic acid 6
CoA 5
ANA 5
Cyclosporine 5
ANA 5
salt 5
calcium 4
acetate 3
sodium chloride 3
phenol 3
oxygen 3
TNF 3
Retinal 3
potassium 3
pyrimidine 3
glucose 3
pyrimidine 3
Lip 3
PAS 3
lysine 2
malonyl-CoA 2
Thyroid 2
Prednisolone 2
FK506 2
Estrogen 2
DES 2
glycerol 2
PVA 2
ACTH 2
copper 2
CO2 2
SDS 2
His 2
Isoproterenol 2
propylene glycol 1
aldehyde 1
phosphate 1
nitrogen 1
iodine 1
fluorine 1
Ketoconazole 1
Neu5,9Ac2 1
Salt 1
Cellulose 1
CIT 1
SAH 1
cAMP 1
GMP 1
INH 1
acetic acid 1
Hypo 1
iron 1
SP-1 1
DBA 1
Practolol 1
guanidine 1
1,3,5-triazine 1
MTT 1
NADPH 1
chlorine 1
PSP 1
Nitrazepam 1
octyl 1
Sodium 1
isoprene 1
Erucic acid 1
GlcNAc 1
o,p'-DDD 1
Lidocaine 1
retinol 1
octyl 1
galactose 1
DHA 1
CTX 1
DBA 1
Prednisone 1
Phytol 1
silver 1
MEK 1
Acyl-CoA 1
NADPH 1
ADP 1
MIT 1
CCP 1
ADP 1
urea 1
Forskolin 1
DBA 1
7beta-hydroxycholesterol 1
BMC 1
ASA 1
CBS 1
Sucralfate 1
GABA 1
aluminum 1
ammonium 1
2-mercaptoethanol 1
Congo red 1
gamma-aminobutyric acid 1
Vitamin A 1
Nervonic acid 1
Pilocarpine 1
ENU 1
DTPA 1
Capsaicin 1
Phytol 1
HVA 1
Triton X-100 1
ADP 1
MIT 1
S-adenosylhomocysteine 1
1,3,5-triazine 1
aldehyde 1
GABA 1
nitrate 1
Ural 1
octyl 1
fluorobenzene 1
Secretin 1
glutamic acid 1
Sialic acid 1
Betamethasone 1