Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022575 (keratoconjunctivitis sicca)
 772 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
lacrimal 126
HRD 82
Sep 48
SS-A 36
SS-B 32
rheumatoid factor 31
lactoferrin 21
lysozyme 19
SSA 17
mucin 16
SSB 16
interferon 15
lamp 14
IgA 14
lymphoid 13
She 12
cytokine 10
long chain 9
HLA 9
collagen 8
Rec 8
LL) 7
PKR 6
Fas 6
CD4 5
fibronectin 5
Mol 5
ANA 5
NOD 5
Cytokine 4
insulin 4
IL-6 4
AQP5 4
IFN 4
epidermal growth factor 4
Rheumatoid factor 4
p68 kinase 3
MUC5AC 3
ribonucleoprotein 3
CD25 3
CD8 3
bcl-2 3
amylase 3
MRI 3
STAT1 3
lectin 3
HLA-DR 3
TNF 3
p48 3
all-trans 3
RNP 3
HLA-DR4 3
prealbumin 2
alpha-fodrin 2
lipase 2
glycoprotein 2
TSP 2
B10 2
adenosine deaminase 2
chronic renal failure 2
class II antigen 2
alternatively spliced 2
STAT2 2
Sp1 2
APO-1 2
chemokine 2
DES 2
ERK 2
SDS 2
granzyme A 2
HLA-DR3 2
cytokeratin 2
reserved 2
endoplasmic reticulum 2
tumor necrosis factor 2
membrane-bound 2
peroxidase 2
caspase-3 2
ACTH 2
polypeptide 2
perforin 2
MMP-9 2
bax 2
olfactory 2
interferon-inducible 2
ARA 2
HLA-B27 2
Fas ligand 2
ADAR1 2
DR4 2
GABA 1
fibrinogen 1
MIP-1alpha 1
Ro60 1
tumor necrosis factor alpha 1
enigma 1
gut 1
lamin A/C 1
NOV 1
OCT 1
carbonic anhydrase VI 1
thymus 1
ankylosing spondylitis 1
CASP 1
ITSN2 1
adenyl cyclase 1
Protein kinase 1
PI3K 1
Bcl-2 1
transthyretin 1
San 1
ASA 1
JAK1 1
CCP 1
transcription factor Sp1 1
HCD 1
Boc 1
intercellular adhesion molecule 1 1
EPA 1
TBM 1
dopamine D2 receptor 1
Growth hormone 1
TCR 1
HST 1
protease inhibitor 1
core protein 1
nerve growth factor 1
phosphoinositide 3-kinase 1
heavy chain 1
cytochrome c 1
cysteine-rich secretory protein 3 1
cyclic nucleotide phosphodiesterase 1
Ro52 1
pseudoxanthoma elasticum 1
secretin 1
glucocorticoid receptor 1
beta-tubulin 1
B12 1
hepatocyte growth factor 1
sensitive to apoptosis gene 1
KRAS 1
interleukin 2 receptor 1
CRB 1
TBCE 1
MAR 1
DDB1 1
E-selectin 1
SAH 1
FIB 1
p42 1
beta 1 1
TIMP 1
beta-2-microglobulin 1
growth hormone 1
threonyl-tRNA synthetase 1
EST 1
MEK 1
glutamate decarboxylase 1
HLA B44 1
IL-22 1
fused 1
MIP-1beta 1
Cyr61 1
aniridia 1
MSC 1
rapa 1
ACID 1
type I interferon 1
alpha-tubulin 1
RNA polymerase I 1
UND 1
DGK-theta 1
PRDM1 1
CHD7 1
DDX6 1
glutamic acid decarboxylase 1
autoantigen 1
Ban 1
IRF5 1
Metalloproteinase 1
renal amyloidosis 1
PER 1
PVA 1
CCL4 1
CTR1 1
HSF 1
PAL 1
CAD 1
Mucin 1
ERK1 1
parotid secretory protein 1
mouse homolog 1
cytokeratin 14 1
hinge 1
ADM 1
p150 1
TNFAIP3 1
microsomal 1
p44 1
FK506 1
calmodulin 1
UTR 1
IL-17 1
NADPH 1
non-Hodgkin's lymphoma 1
CYP 1
SATB1 1
IRF9 1
JNK 1
interferon-alpha 1
interferon alpha 1
PHIP 1
K10 1
B-5 1
DM1 1
IL-1 1
TNPO3 1
TNIP1 1
ESR 1
Men 1
interleukin-17 1
aquaporin 1
DNA-binding protein 1
creatine kinase 1
CD14 1
purinergic receptor 1
S100 1
BSS 1
caspase-9 1
Pol 1
ISGF-3 1
HLA-D 1
LCD 1
alanine aminotransferase 1
GRP78 1
IGF-I 1
SGB 1
FCGR2A 1
superoxide dismutase 1
IGF-1 1
2',5'-oligoadenylate synthetase 1
LIP1 1
C30 1
DR3 1
GPAT 1
forkhead box P3 1
urokinase-type plasminogen activator 1
p38 mitogen-activated protein kinase 1
CD57 1
histidyl-tRNA synthetase 1
SAG 1
DBA 1
SGS 1
FAM167A 1
STD 1
p46 1
CREST 1
BLK 1
TNF receptor 1
vasoactive intestinal peptide 1
Pseudomonas 1
ROC2 1
CXCR5 1
vascular cell adhesion molecule-1 1
2-5A synthetase 1
interferon-gamma 1
extracellular signal-regulated kinase 1
DDB2 1
ATP-binding cassette 1
BCAN 1
ERF 1
C18 1
TAG-1 1
FAG 1
thrombospondin 1
P2Y2 1
MHC 1
SIMPL 1
extracellular signal-regulated kinase 1 1
LIV-1 1
caspase-8 1
IFN-gamma 1
IL-1 alpha 1
RNP antigen 1
TNF-alpha 1
prolactin receptor 1
ADP 1
Id3 1
CD1 1
cystatin C 1
MMP-2 1
acetylcholinesterase 1
ubiquitin 1
thyroglobulin 1
EGF 1
cytochrome P450 1
HDL 1
La protein 1
Nrf2 1
CUT 1
FHOD1 1
Gal 1
IFNAR 1
Human leukocyte antigen 1
tRNA 1
kappa light chain variable region 1
S100A7 1
Albumin 1
PTTG1 1
methyltransferase 1
MYB 1
CBS 1
P38 1
Ig-alpha 1
CER1 1
alanyl-tRNA synthetase 1
adhesion molecule 1
vasopressin 1
PSP 1
human leukocyte antigen 1
more...
Disease
keratoconjunctivitis sicca 772
xerostomia 158
KCS 82
autoimmune disease 77
cornea 59
rheumatoid arthritis 56
conjunctiva 43
systemic lupus erythematosus 41
conjunctivitis 36
arthritis 34
keratitis 34
vasculitis 32
Sjogren's syndrome 26
uveitis 25
sialadenitis 23
graft-versus-host disease 22
cataract 22
glaucoma 19
blepharitis 18
tumor 18
dry eye syndrome 18
PSS 17
lymphoma 17
connective tissue disease 17
scleroderma 16
keratopathy 16
keratoconjunctivitis 15
cancer 15
systemic disease 14
scleritis 14
Cornea 14
neuropathy 14
anterior uveitis 14
Cornea 14
pemphigoid 13
corneal ulcer 13
Raynaud's phenomenon 13
lupus 13
epiphora 13
eye disease 12
episcleritis 12
Stevens-Johnson syndrome 12
xerophthalmia 11
sarcoidosis 11
lymphadenopathy 10
lupus 10
sicca syndrome 9
prolapse 9
primary biliary cirrhosis 9
immunodeficiency 9
blindness 8
amyloidosis 8
diabetes 8
optic neuritis 7
anemia 7
HIV 7
pruritus 6
hypergammaglobulinemia 6
hypothyroidism 6
intraocular pressure 6
interstitial pneumonia 6
dermatitis 6
rosacea 6
parotitis 6
hepatitis 5
multiple sclerosis 5
trichiasis 5
NOD 5
pancreatitis 5
fibromyalgia 5
dacryocystitis 5
dacryoadenitis 5
iridocyclitis 5
osteoarthritis 5
proptosis 5
dental caries 5
polymyositis 5
autonomic neuropathy 5
allergic conjunctivitis 4
thrombocytopenia 4
interstitial nephritis 4
renal disease 4
blepharoconjunctivitis 4
psoriasis 4
leukemia 4
entropion 4
hepatitis C 4
arthropathy 4
iritis 4
Epstein 4
ulcerative colitis 4
atopic dermatitis 4
pleurisy 4
Syndrome 4
lagophthalmos 4
rash 4
pneumonia 4
renal tubular acidosis 4
glomerulonephritis 4
juvenile rheumatoid arthritis 4
pulmonary fibrosis 4
infectious conjunctivitis 4
B-cell lymphoma 4
nephritis 4
retinopathy 3
herpes simplex 3
mixed connective tissue disease 3
mononeuritis 3
autoimmune thyroiditis 3
proteinuria 3
myopathy 3
polyneuropathy 3
cholestasis 3
otitis media 3
dysplasia 3
myositis 3
asthma 3
peritonitis 3
SEM 3
Orbit 3
Primary Sjogren's syndrome 3
Parotid enlargement 3
peripheral neuropathy 3
chronic hepatitis 3
bronchiolitis 3
hemolytic anemia 3
lymphoproliferative disorders 3
colitis 3
Anterior 3
xanthoma 3
EBV infection 3
SLE 3
virus infection 3
skin disease 3
Lip 3
ischemia 3
chronic conjunctivitis 3
stomatitis 3
atrophic gastritis 3
ischemic optic neuropathy 3
carcinoma 3
erythroderma 3
adult T-cell leukemia/lymphoma 3
polyarthritis 3
HAM 3
interstitial lung disease 3
cystic fibrosis 3
vascular disease 3
leishmaniasis 3
Hodgkin's disease 3
lichen planus 3
nephrotic syndrome 3
AIDS 3
xerosis 3
psoriatic arthritis 3
herpes 3
parvovirus 2
multiple myeloma 2
onychogryphosis 2
cholangitis 2
liver disease 2
mental retardation 2
migraine 2
chronic renal failure 2
Conjunctiva 2
periodontitis 2
epilepsy 2
Raynaud 2
choroiditis 2
renal failure 2
lymphocytosis 2
lupus nephritis 2
astigmatism 2
SDS 2
keratoconus 2
macroglobulinemia 2
dysautonomia 2
Submandibular gland 2
dementia 2
thyroiditis 2
myelopathy 2
West 2
HLA-B27 2
chronic pancreatitis 2
meibomitis 2
diplopia 2
Superior limbic keratoconjunctivitis 2
Infection 2
Conjunctiva 2
Kenny-Caffey syndrome 2
incontinence 2
myasthenia 2
sickle cell disease 2
bacterial infection 2
hypoparathyroidism 2
esophageal stricture 2
acute pancreatitis 2
interstitial keratitis 2
plaque 2
synovitis 2
aqueous humor 2
sclera 2
hyperproteinemia 2
endophthalmitis 2
uvea 2
aphthous stomatitis 2
polyarthralgia 2
Peripheral ulcerative keratitis 2
squamous cell carcinoma 2
hyperparathyroidism 2
aplastic anemia 2
vagina 2
ectropion 2
dysphagia 2
Poland 2
nystagmus 2
DES 2
cytomegalovirus 2
Chronic GVHD 2
neutropenia 2
CREST 2
meningitis 2
rubella 2
coronary artery disease 2
meningoencephalomyelitis 2
mental retardation 2
rheumatism 2
vitamin A deficiency 2
retinitis 2
Mikulicz 2
facial palsy 2
vitiligo 2
retinal detachment 2
neurological disease 2
osteosclerosis 2
corneal edema 2
herpes zoster 2
confusion 2
infectious diseases 2
renal insufficiency 1
telangiectasia 1
pemphigus 1
fasciitis 1
stroke 1
Leber's hereditary optic neuropathy 1
scleromalacia 1
peptic ulcer 1
hay fever 1
adrenal hyperplasia 1
Facial nerve paresis 1
infestation 1
staphylococcus 1
Chlamydia 1
heart block 1
heart failure 1
Toxic epidermal necrolysis 1
Retinal vasculitis 1
giant cell arteritis 1
muscular dystrophy 1
SLE with diffuse proliferative glomerulonephritis 1
Best 1
polyarteritis nodosa 1
gallstones 1
pericarditis 1
gammopathy 1
heavy chain disease 1
Familial amyloid polyneuropathy 1
lung disease 1
eyelid dermatitis 1
chorioretinitis 1
Aqueous tear deficiency 1
choroidopathy 1
myocarditis 1
pseudoxanthoma elasticum 1
sensory neuropathy 1
renal papillary necrosis 1
Lupus 1
myopia 1
pulmonic stenosis 1
Cushing's disease 1
invasive thymoma 1
Goldenhar syndrome 1
periodontal disease 1
DM1 1
anhidrosis 1
purpura 1
medullary thyroid carcinoma 1
cleft palate 1
hepatitis B 1
renal impairment 1
plateau iris 1
lymphadenitis 1
Nelson 1
PAL 1
genetic disorder 1
Lymphocytic infiltration 1
metastases 1
anisometropia 1
FFM 1
cold 1
proctalgia fugax 1
arthrodesis 1
Fungal keratitis 1
petechiae 1
thymoma 1
non-Hodgkin's lymphoma 1
DBA 1
pancreatic insufficiency 1
bronchiectasis 1
Annular erythema 1
bronchitis 1
breast cancer 1
pancytopenia 1
macular degeneration 1
Fox 1
autoimmune hemolytic anemia 1
pernicious anemia 1
encephalitis 1
panniculitis 1
hypertensive retinopathy 1
more...
Symptom
dry eye 123
discomfort 21
discomfort 21
pain 16
fatigue 13
thinning 8
photophobia 6
seizures 6
anesthesia 6
sialectasis 5
blepharospasm 5
arthralgia 4
myalgia 4
blurred vision 3
splenomegaly 3
erythema 3
weakness 3
agitation 2
numbness 2
cough 2
diarrhea 2
dysesthesia 2
eye pain 2
dyspnea 2
vomiting 2
Kayser-Fleischer ring 1
spasm 1
finger pain 1
DNA marker 1
back pain 1
livedo 1
dystonia 1
partial seizure 1
polymyalgia 1
overweight 1
dizziness 1
eye discharge 1
angina 1
polyuria 1
hoarseness 1
fasciculation 1
sciatica 1
enuresis 1
adenitis 1
aniseikonia 1
tingling 1
functional recovery 1
shortness of breath 1
abdominal discomfort 1
headache 1
abdominal pain 1
hemoptysis 1
colic 1
epigastric pain 1
Drug
Dermatol 4
Fluorescein 3
Fluorescein 3
Pilocarpine 2
Prednisolone 2
Asthma 2
Sodium hyaluronate 2
ascorbate 2
Rituximab 2
Retinoic Acid 1
Sucralfate 1
Citric acid 1
Growth hormone 1
Ketoconazole 1
lysine 1
IFN-gamma 1
Tuberculin 1
Albumin 1
CTX 1
Cellulose acetate 1
Methylcellulose 1
Forskolin 1
Growth hormone 1
Tacrolimus 1
Vitamin A 1
Ketalar 1
Prednisone 1
uPA 1
PTH 1
Secretin 1
Retinoic acid 1
Solcoseryl 1
ADM 1
ROC 1
MgSO4 1
DM1 1
NOV 1
KCL 1
Enzyme
lysozyme 19
protein kinase 7
fatty acid elongase 5
acyl-CoA synthetase 5
TSP-1 3
focal adhesion kinase 3
mitogen-activated protein kinase 3
lipase 2
caspase-3 2
estrogen sulfotransferase 2
adenosine deaminase 2
ribonuclease 2
chloramphenicol acetyltransferase 2
peroxidase 2
ribonuclease 2
RNase 2
RNase 2
adenosine deaminase 2
ERK 2
alanyl-tRNA synthetase 1
urokinase-type plasminogen activator 1
neuraminidase 1
CAD 1
4CL 1
phosphoinositide 3-kinase 1
citrate synthase 1
ACE 1
fatty acyl-CoA reductase 1
PAL 1
ascorbate peroxidase 1
histidyl-tRNA synthetase 1
MEK 1
condensing enzyme 1
PDE 1
superoxide dismutase 1
glutamate decarboxylase 1
RNA polymerase 1
fatty-acyl-CoA synthase 1
elastase 1
adenylate cyclase 1
reverse transcriptase 1
CAD 1
PAL 1
CAD 1
TRS 1
alanine aminotransferase 1
glycerophosphate acyltransferase 1
trypsin 1
creatine kinase 1
carbonic anhydrase 1
plasmin 1
Compound
Clin 70
Dec 39
sodium 22
DNA 17
Rose Bengal 13
water 12
sulfate 8
hyaluronic acid 6
retinoic acid 6
CoA 5
ANA 5
Cyclosporine 5
ANA 5
salt 5
calcium 4
acetate 3
sodium chloride 3
phenol 3
oxygen 3
TNF 3
Retinal 3
potassium 3
pyrimidine 3
glucose 3
pyrimidine 3
Lip 3
PAS 3
lysine 2
malonyl-CoA 2
Thyroid 2
Prednisolone 2
FK506 2
Estrogen 2
DES 2
glycerol 2
PVA 2
ACTH 2
copper 2
CO2 2
SDS 2
His 2
Isoproterenol 2
propylene glycol 1
aldehyde 1
phosphate 1
nitrogen 1
iodine 1
fluorine 1
Ketoconazole 1
Neu5,9Ac2 1
Salt 1
Cellulose 1
CIT 1
SAH 1
cAMP 1
GMP 1
INH 1
acetic acid 1
Hypo 1
iron 1
SP-1 1
DBA 1
Practolol 1
guanidine 1
1,3,5-triazine 1
MTT 1
NADPH 1
chlorine 1
PSP 1
Nitrazepam 1
octyl 1
Sodium 1
isoprene 1
Erucic acid 1
GlcNAc 1
o,p'-DDD 1
Lidocaine 1
retinol 1
octyl 1
galactose 1
DHA 1
CTX 1
DBA 1
Prednisone 1
Phytol 1
silver 1
MEK 1
Acyl-CoA 1
NADPH 1
ADP 1
MIT 1
CCP 1
ADP 1
urea 1
Forskolin 1
DBA 1
7beta-hydroxycholesterol 1
BMC 1
ASA 1
CBS 1
Sucralfate 1
GABA 1
aluminum 1
ammonium 1
2-mercaptoethanol 1
Congo red 1
gamma-aminobutyric acid 1
Vitamin A 1
Nervonic acid 1
Pilocarpine 1
ENU 1
DTPA 1
Capsaicin 1
Phytol 1
HVA 1
Triton X-100 1
ADP 1
MIT 1
S-adenosylhomocysteine 1
1,3,5-triazine 1
aldehyde 1
GABA 1
nitrate 1
Ural 1
octyl 1
fluorobenzene 1
Secretin 1
glutamic acid 1
Sialic acid 1
Betamethasone 1