Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022575 (keratoconjunctivitis sicca)
 772 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
HRD 13.7
FAM167A 11.3
SIMPL 11.2
BCAN 11.2
ITSN2 11.2
SS-B 11.0
ROC2 10.9
SS-A 10.9
HLA B44 10.9
kappa light chain variable region 10.9
DGK-theta 10.7
ISGF-3 10.6
DQw 10.5
TNPO3 9.9
cysteine-rich secretory protein 3 9.9
lacrimal 9.8
TBCE 9.7
FAM83H 9.6
FAG 9.5
p68 kinase 9.4
RNP antigen 9.3
LIP1 9.3
parotid secretory protein 9.3
PHIP 9.3
carbonic anhydrase VI 9.3
sensitive to apoptosis gene 9.2
CER1 9.2
TNIP1 9.0
LIV-1 9.0
SSB 8.9
GPAT 8.8
FHOD1 8.8
Rheumatoid factor 8.8
SSA 8.6
IL12A 8.4
DDX6 8.4
heterogeneous nuclear ribonucleoprotein A1 8.4
PTTG1 8.3
BLK 8.3
p48 8.3
alpha-fodrin 8.2
HST 8.1
threonyl-tRNA synthetase 7.9
rheumatoid factor 7.9
alanyl-tRNA synthetase 7.9
AQP5 7.9
B-5 7.9
CUT 7.8
histidyl-tRNA synthetase 7.8
FCGR2A 7.8
SATB1 7.7
DQw3 7.7
UND 7.6
tricellulin 7.6
NOV 7.6
PRDM1 7.6
ADAR1 7.5
Ig-alpha 7.5
ACID 7.5
DDB2 7.4
Hey2 7.3
U1-70K 7.3
IRF9 7.3
IRF5 7.2
Ro60 7.2
Cyr61 7.2
granzyme A 7.2
2',5'-oligoadenylate synthetase 7.2
CRB 7.2
p46 7.2
lactoferrin 7.1
CTR1 7.1
La protein 7.0
BSS 7.0
S100A7 6.9
STAT2 6.9
PKR 6.9
class II antigen 6.9
HLA-DR4 6.8
Id3 6.8
TAG-1 6.8
ARA 6.7
Ro52 6.7
wich 6.7
interferon-inducible 6.7
SGB 6.6
TBM 6.6
HCD 6.6
cytokeratin 14 6.6
DDB1 6.6
TNFAIP3 6.6
CASP 6.6
HLA-DR3 6.5
CREST 6.5
MUC5AC 6.5
Metalloproteinase 6.5
SGS 6.5
autoimmune regulator 6.5
SAG 6.4
IFNAR 6.4
LL) 6.3
CHD7 6.3
pseudoxanthoma elasticum 6.3
ANA 6.3
lamp 6.1
mouse homolog 6.1
NF-IL6 6.1
2-5A synthetase 5.9
MAR 5.9
DES 5.9
APO-1 5.9
forkhead box P3 5.9
lipid transfer protein 5.9
p150 5.9
aniridia 5.8
LCD 5.8
long chain 5.8
beta-2-microglobulin 5.8
HSF 5.7
STAT4 5.7
transcription factor Sp1 5.7
RNP 5.7
ERF 5.7
prolactin receptor 5.6
TIMP 5.6
Human leukocyte antigen 5.6
HLA-D 5.6
lamin A/C 5.6
SAH 5.6
CCP 5.6
CXCR5 5.6
P2Y2 5.5
PSP 5.5
adenyl cyclase 5.5
mucin 5.4
prealbumin 5.4
MIP-1beta 5.4
purinergic receptor 5.3
TSP 5.3
PAL 5.2
lysozyme 5.2
PER 5.2
interleukin 2 receptor 5.2
CTGF 5.2
HLA-B27 5.2
CCL4 5.2
renal amyloidosis 5.1
Mucin 5.0
bax 5.0
human leucocyte antigen 5.0
cyclic nucleotide phosphodiesterase 5.0
Protein kinase 5.0
CRL 5.0
interleukin-17 5.0
NOD 5.0
P38 4.8
CAL 4.7
DR4 4.7
FIB 4.7
STAT1 4.7
more...
Disease
Diffuse scleritis 15.3
keratoconjunctivitis sicca 15.3
Necrotizing conjunctivitis 15.3
SLE with diffuse proliferative glomerulonephritis 15.3
KCS 14.9
EBMD 14.3
Papillary conjunctivitis 14.3
Aqueous tear deficiency 13.0
Superior limbic keratoconjunctivitis 13.0
Chronic blepharitis 13.0
Parotid enlargement 12.3
Facial nerve paresis 12.2
Primary Sjogren's syndrome 12.2
Peripheral ulcerative keratitis 12.2
meibomitis 11.9
infectious conjunctivitis 11.6
Annular erythema 11.4
HIV retinopathy 11.0
episcleritis 10.7
dry eye syndrome 10.7
xerostomia 10.6
Conjunctiva 10.5
Conjunctiva 10.5
Posterior scleritis 10.4
blepharitis 10.3
onychogryphosis 10.3
Kenny-Caffey syndrome 10.2
Soft palate 10.2
blepharoconjunctivitis 10.1
Retinal vasculitis 10.0
dacryoadenitis 10.0
plateau iris 10.0
Submandibular gland 9.9
eyelid dermatitis 9.8
xerophthalmia 9.8
chronic conjunctivitis 9.8
sclerokeratitis 9.8
proctalgia fugax 9.7
Acute anterior uveitis 9.7
sialadenitis 9.7
Sjogren's syndrome 9.7
scleritis 9.7
scleromalacia 9.6
inflamed eye 9.6
sicca syndrome 9.6
trichiasis 9.4
superficial keratitis 9.3
corneal ulcer 9.3
esophageal web 9.2
Distal renal tubular acidosis 9.1
cyclitis 9.1
pinguecula 8.9
Herpesvirus infection 8.9
epiphora 8.9
lagophthalmos 8.9
dacryocystitis 8.9
keratoconjunctivitis 8.8
keratopathy 8.8
hyperproteinemia 8.8
interstitial keratitis 8.7
Familial amyloid polyneuropathy 8.7
entropion 8.7
Mooren's ulcer 8.6
meningoencephalomyelitis 8.6
anterior uveitis 8.6
iridocyclitis 8.6
EIN 8.5
retinal vascular occlusion 8.5
HRD 8.4
Multiple chemical sensitivity 8.4
heavy chain disease 8.4
parotitis 8.4
conjunctiva 8.3
Fungal keratitis 8.3
Stevens-Johnson syndrome 8.3
other autoimmune disease 8.3
conjunctivitis 8.2
Lymphocytic infiltration 8.1
SGS 8.1
keratitis 8.1
iritis 8.0
mononeuritis 8.0
panophthalmitis 7.9
Mikulicz 7.9
bacterial conjunctivitis 7.9
choroidopathy 7.9
allergic conjunctivitis 7.8
SGS 7.8
Facial palsy 7.7
Raynaud's phenomenon 7.6
choroiditis 7.6
connective tissue disease 7.5
hypergammaglobulinemia 7.5
eye disease 7.5
cycloplegia 7.4
pemphigoid 7.4
xerosis 7.3
rosacea 7.3
polyarthralgia 7.3
renal papillary necrosis 7.2
ischemic optic neuropathy 7.2
bilateral cataracts 7.2
ocular herpes 7.2
polyclonal hypergammaglobulinemia 7.2
Lip 7.2
uveitis 7.2
poikiloderma 7.1
Chronic GVHD 7.1
uvea 7.0
xanthoma 7.0
hypertensive retinopathy 7.0
aphthous stomatitis 7.0
autoimmune disease 7.0
invasive thymoma 7.0
Urbach 7.0
CREST 6.9
scleroderma 6.8
caruncle 6.8
sclerodactyly 6.8
ocular toxoplasmosis 6.8
optic neuritis 6.7
cornea 6.7
pleurisy 6.7
sialolithiasis 6.7
ectropion 6.6
mixed connective tissue disease 6.6
Goldenhar syndrome 6.6
osteosclerosis 6.5
esophageal stricture 6.5
corneal edema 6.5
Atrophic 6.5
dysautonomia 6.5
biliary colic 6.4
anisometropia 6.4
renal tubular acidosis 6.4
autonomic neuropathy 6.3
anhidrosis 6.3
panuveitis 6.3
primary biliary cirrhosis 6.3
orbital cellulitis 6.2
erythroderma 6.2
Cornea 6.2
Cornea 6.2
localized scleroderma 6.2
myasthenia 6.2
disabling disease 6.1
juvenile rheumatoid arthritis 6.1
interstitial nephritis 6.1
systemic disease 6.1
vasculitis 6.0
anemia of chronic disease 6.0
PSS 6.0
polymyositis 6.0
xanthogranuloma 6.0
autoimmune thyroiditis 5.9
Orbit 5.9
cutis laxa 5.9
Whipple's disease 5.9
exotropia 5.8
DES 5.8
more...
Symptom
sialectasis 12.1
dry eye 10.9
finger pain 10.1
eye discharge 9.2
Kayser-Fleischer ring 9.1
polymyalgia 8.5
aniseikonia 8.2
eye pain 7.8
blepharospasm 7.7
photophobia 7.3
dysesthesia 6.4
adenitis 6.2
partial seizure 5.9
blurred vision 5.9
livedo 5.6
DNA marker 5.5
discomfort 5.3
discomfort 5.1
tingling 5.0
fasciculation 5.0
thinning 4.9
sciatica 4.7
myalgia 4.7
enuresis 4.6
abdominal discomfort 4.6
arthralgia 4.5
numbness 4.0
hoarseness 3.8
polyuria 3.8
colic 3.7
splenomegaly 3.6
epigastric pain 3.6
fatigue 3.4
erythema 3.2
shortness of breath 3.0
agitation 2.8
hemoptysis 2.8
spasm 2.5
dystonia 2.3
dizziness 2.1
cough 1.8
back pain 1.8
weakness 1.7
seizures 1.6
functional recovery 1.6
dyspnea 1.6
vomiting 1.4
pain 1.3
anesthesia 1.2
angina 1.0
overweight 0.6
diarrhea 0.5
abdominal pain 0.4
headache -0.4
Drug
Sodium hyaluronate 9.0
Ketalar 8.8
Methylcellulose 8.5
Solcoseryl 8.5
NOV 7.6
Cellulose acetate 7.3
KCL 7.3
Sucralfate 7.2
Pilocarpine 7.0
Retinoic Acid 6.8
Citric acid 6.3
Tuberculin 6.1
Secretin 5.8
Prednisolone 5.8
Fluorescein 5.5
Prednisone 5.3
Ketoconazole 5.3
Fluorescein 5.0
Rituximab 4.8
MgSO4 4.7
DM1 4.7
Tacrolimus 4.6
uPA 4.3
Forskolin 4.0
Growth hormone 3.8
Vitamin A 3.8
Growth hormone 3.8
ADM 3.7
Retinoic acid 3.6
Albumin 3.1
PTH 2.6
ROC 2.4
CTX 2.0
ascorbate 1.8
Asthma 1.7
IFN-gamma 0.5
lysine -0.5
Dermatol -0.7
Enzyme
fatty-acyl-CoA synthase 13.7
fatty acid elongase 9.7
fatty acyl-CoA reductase 9.4
histidyl-tRNA synthetase 7.8
alanyl-tRNA synthetase 7.6
acyl-CoA synthetase 7.3
condensing enzyme 7.3
estrogen sulfotransferase 7.2
TSP-1 7.2
glycerophosphate acyltransferase 7.0
4CL 7.0
TRS 6.3
lysozyme 5.2
PAL 4.7
PAL 4.3
glutamate decarboxylase 4.2
chloramphenicol acetyltransferase 4.0
adenosine deaminase 4.0
adenosine deaminase 4.0
ascorbate peroxidase 3.9
ribonuclease 3.6
ribonuclease 3.6
PDE 3.5
CAD 3.2
CAD 3.2
citrate synthase 3.2
CAD 3.2
phosphoinositide 3-kinase 2.8
carbonic anhydrase 2.5
RNase 2.3
RNase 2.2
plasmin 2.2
elastase 2.2
lipase 2.1
urokinase-type plasminogen activator 1.9
protein kinase 1.8
neuraminidase 1.5
focal adhesion kinase 1.5
caspase-3 1.2
MEK 1.2
ACE 1.2
creatine kinase 1.1
adenylate cyclase 1.1
alanine aminotransferase 0.6
reverse transcriptase 0.4
mitogen-activated protein kinase 0.4
peroxidase 0.3
RNA polymerase 0.2
trypsin -0.0
ERK -0.2
superoxide dismutase -0.5
Compound
Nervonic acid 11.3
Neu5,9Ac2 9.9
Erucic acid 9.6
Rose Bengal 8.9
Practolol 8.0
7beta-hydroxycholesterol 7.9
Nitrazepam 7.6
Sucralfate 7.3
Betamethasone 6.9
fluorobenzene 6.8
o,p'-DDD 6.7
Ural 6.7
SP-1 6.5
Lip 6.5
Acyl-CoA 6.3
Pilocarpine 6.1
DES 5.8
Prednisolone 5.8
Secretin 5.7
ENU 5.7
SAH 5.7
ANA 5.6
ANA 5.6
malonyl-CoA 5.5
PSP 5.4
Ketoconazole 5.4
Hypo 5.3
Cyclosporine 5.3
Sialic acid 5.2
1,3,5-triazine 4.8
1,3,5-triazine 4.8
Prednisone 4.7
CCP 4.7
HVA 4.6
MIT 4.6
MIT 4.5
Retinal 4.4
hyaluronic acid 4.3
PAS 4.3
PVA 4.3
Lidocaine 4.2
isoprene 4.0
Forskolin 4.0
Capsaicin 4.0
S-adenosylhomocysteine 3.9
CIT 3.9
FK506 3.8
Cellulose 3.8
Vitamin A 3.8
CoA 3.7
Isoproterenol 3.6
INH 3.6
CBS 3.5
sodium chloride 3.4
Congo red 3.4
propylene glycol 3.4
retinoic acid 3.3
2-mercaptoethanol 3.3
Estrogen 3.1
octyl 2.9
octyl 2.9
octyl 2.8
pyrimidine 2.6
DHA 2.6
pyrimidine 2.6
DTPA 2.6
Thyroid 2.4
Phytol 2.3
Phytol 2.3
Salt 2.3
phenol 2.2
DBA 2.2
guanidine 2.2
GMP 2.2
DBA 2.2
Sodium 2.1
ACTH 2.1
retinol 2.0
CTX 2.0
DBA 1.9
sodium 1.7
MEK 1.7
GlcNAc 1.6
sulfate 1.6
Triton X-100 1.4
ASA 1.4
gamma-aminobutyric acid 1.4
chlorine 1.4
glutamic acid 1.3
fluorine 1.2
aldehyde 1.1
glycerol 1.0
TNF 1.0
Clin 0.9
salt 0.9
NADPH 0.7
NADPH 0.7
aldehyde 0.7
SDS 0.6
aluminum 0.5
potassium 0.4
MTT 0.3
GABA 0.3
GABA 0.2
acetic acid 0.2
ADP 0.1
ADP 0.1
His 0.1
acetate 0.1
lysine 0.0
ADP -0.0
CO2 -0.1
copper -0.2
DNA -0.2
iodine -0.3
nitrate -0.4
Dec -0.4
water -0.5
cAMP -0.5
silver -0.5
ammonium -0.6
urea -0.6
galactose -0.9
calcium -1.0
glucose -1.3
oxygen -1.6
iron -1.7
nitrogen -1.9
phosphate -2.1
BMC -2.2