Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022575 (keratoconjunctivitis sicca)
 772 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
lacrimal 126
HRD 82
Sep 48
SS-A 36
SS-B 32
rheumatoid factor 31
lactoferrin 21
lysozyme 19
SSA 17
SSB 16
mucin 16
interferon 15
lamp 14
IgA 14
lymphoid 13
She 12
cytokine 10
long chain 9
HLA 9
Rec 8
collagen 8
LL) 7
PKR 6
Fas 6
ANA 5
CD4 5
Mol 5
NOD 5
fibronectin 5
epidermal growth factor 4
IL-6 4
Rheumatoid factor 4
Cytokine 4
insulin 4
IFN 4
AQP5 4
MRI 3
MUC5AC 3
HLA-DR 3
lectin 3
HLA-DR4 3
TNF 3
CD8 3
ribonucleoprotein 3
STAT1 3
p48 3
p68 kinase 3
RNP 3
CD25 3
amylase 3
bcl-2 3
all-trans 3
ARA 2
tumor necrosis factor 2
caspase-3 2
cytokeratin 2
MMP-9 2
prealbumin 2
HLA-DR3 2
class II antigen 2
perforin 2
alternatively spliced 2
TSP 2
Sp1 2
adenosine deaminase 2
interferon-inducible 2
chronic renal failure 2
chemokine 2
HLA-B27 2
reserved 2
ERK 2
Fas ligand 2
olfactory 2
SDS 2
endoplasmic reticulum 2
B10 2
lipase 2
glycoprotein 2
alpha-fodrin 2
membrane-bound 2
peroxidase 2
bax 2
polypeptide 2
ACTH 2
DES 2
granzyme A 2
APO-1 2
STAT2 2
ADAR1 2
DR4 2
TCR 1
protease inhibitor 1
fibrinogen 1
nerve growth factor 1
heavy chain 1
tumor necrosis factor alpha 1
enigma 1
cysteine-rich secretory protein 3 1
Ro52 1
ERF 1
secretin 1
thymus 1
ankylosing spondylitis 1
CASP 1
ITSN2 1
hepatocyte growth factor 1
KRAS 1
Protein kinase 1
MMP-2 1
MAR 1
transthyretin 1
cytochrome P450 1
E-selectin 1
CCP 1
transcription factor Sp1 1
kappa light chain variable region 1
beta-2-microglobulin 1
Boc 1
intercellular adhesion molecule 1 1
Albumin 1
TBM 1
histidyl-tRNA synthetase 1
FAM167A 1
CBS 1
CREST 1
TNF receptor 1
vasoactive intestinal peptide 1
glutamate decarboxylase 1
HLA B44 1
DDB2 1
C18 1
MIP-1beta 1
FAG 1
aniridia 1
MSC 1
rapa 1
beta-tubulin 1
RNP antigen 1
prolactin receptor 1
ADP 1
UND 1
DGK-theta 1
DDX6 1
glutamic acid decarboxylase 1
autoantigen 1
DDB1 1
Nrf2 1
IRF5 1
CCL4 1
FIB 1
MYB 1
CAD 1
Mucin 1
threonyl-tRNA synthetase 1
mouse homolog 1
cytokeratin 14 1
hinge 1
ERK1 1
p150 1
TNFAIP3 1
more...
Disease
keratoconjunctivitis sicca 772
xerostomia 158
KCS 82
autoimmune disease 77
cornea 59
rheumatoid arthritis 56
conjunctiva 43
systemic lupus erythematosus 41
conjunctivitis 36
keratitis 34
arthritis 34
vasculitis 32
Sjogren's syndrome 26
uveitis 25
sialadenitis 23
graft-versus-host disease 22
cataract 22
glaucoma 19
blepharitis 18
dry eye syndrome 18
tumor 18
connective tissue disease 17
PSS 17
lymphoma 17
scleroderma 16
keratopathy 16
keratoconjunctivitis 15
cancer 15
Cornea 14
neuropathy 14
anterior uveitis 14
systemic disease 14
Cornea 14
scleritis 14
pemphigoid 13
Raynaud's phenomenon 13
lupus 13
epiphora 13
corneal ulcer 13
episcleritis 12
Stevens-Johnson syndrome 12
eye disease 12
xerophthalmia 11
sarcoidosis 11
lymphadenopathy 10
lupus 10
prolapse 9
primary biliary cirrhosis 9
immunodeficiency 9
sicca syndrome 9
diabetes 8
blindness 8
amyloidosis 8
optic neuritis 7
anemia 7
HIV 7
intraocular pressure 6
parotitis 6
dermatitis 6
interstitial pneumonia 6
pruritus 6
hypothyroidism 6
hypergammaglobulinemia 6
rosacea 6
hepatitis 5
fibromyalgia 5
trichiasis 5
iridocyclitis 5
pancreatitis 5
osteoarthritis 5
dental caries 5
dacryocystitis 5
autonomic neuropathy 5
polymyositis 5
proptosis 5
NOD 5
multiple sclerosis 5
dacryoadenitis 5
iritis 4
ulcerative colitis 4
renal disease 4
blepharoconjunctivitis 4
nephritis 4
B-cell lymphoma 4
Epstein 4
arthropathy 4
thrombocytopenia 4
juvenile rheumatoid arthritis 4
hepatitis C 4
atopic dermatitis 4
renal tubular acidosis 4
Syndrome 4
pneumonia 4
rash 4
psoriasis 4
leukemia 4
lagophthalmos 4
pleurisy 4
pulmonary fibrosis 4
interstitial nephritis 4
infectious conjunctivitis 4
entropion 4
allergic conjunctivitis 4
glomerulonephritis 4
herpes 3
Anterior 3
SEM 3
colitis 3
polyneuropathy 3
dysplasia 3
chronic hepatitis 3
Orbit 3
myositis 3
cholestasis 3
skin disease 3
myopathy 3
Lip 3
asthma 3
Parotid enlargement 3
peripheral neuropathy 3
EBV infection 3
hemolytic anemia 3
peritonitis 3
Primary Sjogren's syndrome 3
ischemia 3
autoimmune thyroiditis 3
proteinuria 3
mononeuritis 3
mixed connective tissue disease 3
erythroderma 3
virus infection 3
SLE 3
retinopathy 3
stomatitis 3
otitis media 3
ischemic optic neuropathy 3
xerosis 3
cystic fibrosis 3
AIDS 3
adult T-cell leukemia/lymphoma 3
chronic conjunctivitis 3
HAM 3
polyarthritis 3
Hodgkin's disease 3
vascular disease 3
interstitial lung disease 3
nephrotic syndrome 3
carcinoma 3
lichen planus 3
leishmaniasis 3
lymphoproliferative disorders 3
herpes simplex 3
xanthoma 3
atrophic gastritis 3
psoriatic arthritis 3
bronchiolitis 3
infectious diseases 2
renal failure 2
confusion 2
liver disease 2
more...
Symptom
dry eye 123
discomfort 21
discomfort 21
pain 16
fatigue 13
thinning 8
photophobia 6
seizures 6
anesthesia 6
sialectasis 5
blepharospasm 5
arthralgia 4
myalgia 4
blurred vision 3
splenomegaly 3
erythema 3
weakness 3
agitation 2
numbness 2
cough 2
diarrhea 2
dysesthesia 2
eye pain 2
dyspnea 2
vomiting 2
Kayser-Fleischer ring 1
spasm 1
finger pain 1
DNA marker 1
back pain 1
livedo 1
dystonia 1
partial seizure 1
polymyalgia 1
overweight 1
dizziness 1
eye discharge 1
angina 1
polyuria 1
hoarseness 1
fasciculation 1
sciatica 1
enuresis 1
adenitis 1
aniseikonia 1
tingling 1
functional recovery 1
shortness of breath 1
abdominal discomfort 1
headache 1
abdominal pain 1
hemoptysis 1
colic 1
epigastric pain 1
Drug
Dermatol 4
Fluorescein 3
Fluorescein 3
Pilocarpine 2
Prednisolone 2
Asthma 2
Sodium hyaluronate 2
ascorbate 2
Rituximab 2
Retinoic Acid 1
Sucralfate 1
Citric acid 1
Growth hormone 1
Ketoconazole 1
lysine 1
IFN-gamma 1
Tuberculin 1
Albumin 1
CTX 1
Cellulose acetate 1
Methylcellulose 1
Forskolin 1
Growth hormone 1
Tacrolimus 1
Vitamin A 1
Ketalar 1
Prednisone 1
uPA 1
PTH 1
Secretin 1
Retinoic acid 1
Solcoseryl 1
ADM 1
ROC 1
MgSO4 1
DM1 1
NOV 1
KCL 1
Enzyme
lysozyme 19
protein kinase 7
fatty acid elongase 5
acyl-CoA synthetase 5
TSP-1 3
focal adhesion kinase 3
mitogen-activated protein kinase 3
lipase 2
caspase-3 2
estrogen sulfotransferase 2
adenosine deaminase 2
ribonuclease 2
chloramphenicol acetyltransferase 2
peroxidase 2
ribonuclease 2
RNase 2
RNase 2
adenosine deaminase 2
ERK 2
alanyl-tRNA synthetase 1
urokinase-type plasminogen activator 1
neuraminidase 1
CAD 1
4CL 1
phosphoinositide 3-kinase 1
citrate synthase 1
ACE 1
fatty acyl-CoA reductase 1
PAL 1
ascorbate peroxidase 1
histidyl-tRNA synthetase 1
MEK 1
condensing enzyme 1
PDE 1
superoxide dismutase 1
glutamate decarboxylase 1
RNA polymerase 1
fatty-acyl-CoA synthase 1
elastase 1
adenylate cyclase 1
reverse transcriptase 1
CAD 1
PAL 1
CAD 1
TRS 1
alanine aminotransferase 1
glycerophosphate acyltransferase 1
trypsin 1
creatine kinase 1
carbonic anhydrase 1
plasmin 1
Compound
Clin 70
Dec 39
sodium 22
DNA 17
Rose Bengal 13
water 12
sulfate 8
hyaluronic acid 6
retinoic acid 6
CoA 5
ANA 5
Cyclosporine 5
ANA 5
salt 5
calcium 4
acetate 3
sodium chloride 3
phenol 3
oxygen 3
TNF 3
Retinal 3
potassium 3
pyrimidine 3
glucose 3
pyrimidine 3
Lip 3
PAS 3
lysine 2
malonyl-CoA 2
Thyroid 2
Prednisolone 2
FK506 2
Estrogen 2
DES 2
glycerol 2
PVA 2
ACTH 2
copper 2
CO2 2
SDS 2
His 2
Isoproterenol 2
propylene glycol 1
aldehyde 1
phosphate 1
nitrogen 1
iodine 1
fluorine 1
Ketoconazole 1
Neu5,9Ac2 1
Salt 1
Cellulose 1
CIT 1
SAH 1
cAMP 1
GMP 1
INH 1
acetic acid 1
Hypo 1
iron 1
SP-1 1
DBA 1
Practolol 1
guanidine 1
1,3,5-triazine 1
MTT 1
NADPH 1
chlorine 1
PSP 1
Nitrazepam 1
octyl 1
Sodium 1
isoprene 1
Erucic acid 1
GlcNAc 1
o,p'-DDD 1
Lidocaine 1
retinol 1
octyl 1
galactose 1
DHA 1
CTX 1
DBA 1
Prednisone 1
Phytol 1
silver 1
MEK 1
Acyl-CoA 1
NADPH 1
ADP 1
MIT 1
CCP 1
ADP 1
urea 1
Forskolin 1
DBA 1
7beta-hydroxycholesterol 1
BMC 1
ASA 1
CBS 1
Sucralfate 1
GABA 1
aluminum 1
ammonium 1
2-mercaptoethanol 1
Congo red 1
gamma-aminobutyric acid 1
Vitamin A 1
Nervonic acid 1
Pilocarpine 1
ENU 1
DTPA 1
Capsaicin 1
Phytol 1
HVA 1
Triton X-100 1
ADP 1
MIT 1
S-adenosylhomocysteine 1
1,3,5-triazine 1
aldehyde 1
GABA 1
nitrate 1
Ural 1
octyl 1
fluorobenzene 1
Secretin 1
glutamic acid 1
Sialic acid 1
Betamethasone 1