Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022575 (
keratoconjunctivitis sicca
)
772
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Very long chain fatty acids (VLCFAs) that are structural components of cell membrane lipid, cuticular waxes and seed oil, play crucial roles in plant growth, development and stress response. Fatty acid elongases (FAEs) comprising
KCS
and ELO, are key enzymes for VLCFA biosynthesis in plants. Although reference genomes of Brassica napus and its parental speices both have been sequenced, whole-genome analysis of FAE gene family in these Brassica speices is not reported. Here, 58, 33 and 30
KCS
genes were identified in B. napus, B.
rapa
and B. oleracea genomes, respectively, whereas 14, 6 and 8 members were obtained for ELO genes. These
KCS
genes were unevenly located in 37 chromosomes and 3 scaffolds of 3 Brassica species, while these ELO genes were mapped to 19 chromosomes. The
KCS
and ELO proteins were divided into 8 and 4 subclasses, respectively. Gene structure and protein motifs remained highly conserved in each
KCS
or ELO subclass. Most promoters of
KCS
and ELO genes harbored various plant growth-, phytohormone-, and stress response-related cis-acting elements. 20 SSR loci existed in the
KCS
and ELO genes/promoters. The whole-genome duplication and segmental duplication mainly contributed to expansion of
KCS
and ELO genes in these genomes. Transcriptome analysis showed that
KCS
and ELO genes in 3 Brassica species were expressed in various tissues/organs with different levels, whereas 1 BnELO gene and 6 BnKCS genes might be pathogen-responsive genes. The qRT-PCR assay showed that BnKCS22 and BnELO04 responded to various phytohormone treatments and abiotic stresses. This work lays the foundation for further function identification of
KCS
and ELO genes in B. napus and its progenitors.
...
PMID:Genome-wide mining and comparative analysis of fatty acid elongase gene family in Brassica napus and its progenitors. 3230 81
