Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022575 (keratoconjunctivitis sicca)
 772 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relevance of antibodies for La(SSB) as a marker of a distinctive systemic lupus erythematosus (SLE) subset was studied in 185 lupus patients. Anti La was detected in 39 (21%) and was accompanied invariably by anti Ro. Clinically, anti La-positive patients were distinguished by a later age of disease onset, and a low frequency of lupus nephritis. In common with other anti Ro-positive patients they showed a high frequency of keratoconjunctivitis sicca. Anti La identified patients with higher titres of anti Ro antibodies and was significantly associated with HLA-DR3. Serological markers such as these are useful for identifying more homogeneous populations of SLE patients for studies of aetiology and pathogenesis.
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PMID:Anti La(SSB) identifies a distinctive subgroup of systemic lupus erythematosus. 325 99

Sjogren's Syndrome (SS) is a chronic, female overwhelming fundamental issue of an immune system rheumatic sickness that influences the whole body. It is described by lymphocytic invasion of the exocrine viz. salivary and lacrimal glands and by surprising B-cell hyperactivity. Keratoconjunctivitis sicca (dry eye) and Stomatitis sicca (oral dryness) are the primary visual appearances of SS. The primary SS is recognized from secondary SS which happens as a piece of other immune system maladies. The secondary SS exists together particularly with fundamental lupus erythematosus (15- 36%), rheumatoid joint inflammation (20- 32%) and also restricted and progressive systemic sclerosis (11- 24%), less as often as possible with different sclerosis and immune system hepatitis and thyreoiditis. We assess changes in salivary epidermal growth factor (EGF) intensity and estimate the relationship between salivary EGF levels and the seriousness of intraoral symptoms in SS individuals. The outcomes demonstrated that the salivary EGF levels diminished with the movement of SS, and this crumbling in salivation quality and additionally, hyposalivation could imagine a vital constituent in the pathogenesis of refractory intraoral indication in SS suffering patients. A strong relationship between particular alleles of the MHC and SS improvement has been recommended. The primary hereditary examination on SS revealed a relationship amongst SS and HLA-DR3 in SS population. Subsequent reports featured the relationship amongst SS and the HLA-D locus, with a diverse distribution between primary SS and secondary SS. The motivation behind this manuscript is to give a concise survey on the molecular mechanism, effects of infectious agents and genetic factors in the etiology of Sjogren's Syndrome. Such effects are discussed independently.
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PMID:From Molecular Mechanism to the Etiology of Sjogren Syndrome. 3033 43