Gene/Protein
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Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: UMLS:C0022575 (
keratoconjunctivitis sicca
)
772
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report the effects of
CBS
-211 A, a synthetic retinoic acid analog, on a previously described experimental model of
keratoconjunctivitis sicca
(
KCS
) in the rabbit. A 9-week topical treatment with 0.02%
CBS
-211 A in aqueous vehicle significantly increased the conjunctival goblet cell density (P less than 0.01, impression cytology counting), stopped the evolution of the corneo-conjunctival surface alteration (P less than 0.05, rose bengal test), and restored a basically normal mucosecretory product quality in goblet cells (lectin histochemistry) compared to vehicle treatment. The results assess the efficacy of this compound in reversing
KCS
pathology in a relevant model different from general vitamin A deficiency models, and strongly support the rationale for using such a well-tolerated retinoid in dry eye treatment.
...
PMID:Beneficial effects of a retinoic acid analog, CBS-211 A, on an experimental model of keratoconjunctivitis sicca. 173 May 41
