Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022575 (keratoconjunctivitis sicca)
 772 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors evaluated ocular involvement in 23 patients affected by rheumatoid arthritis (RA) according to ARA criteria. Slit-lamp biomicroscopic examination showed signs of keratoconjunctivitis sicca in one patient (4%), while a positive bilateral Schirmer test was found in six subjects (26%). Fluorescein angiography, carried out in 11 of the 23 RA patients, showed retinal vasculitis in 18% of the patients examined, even if no clinical and ophthalmoscopic signs of retinal vessel inflammation were present. The authors suggest that fluorescein angiography should be performed in patients affected by particularly active RA, with recent onset of the disease (< 12 months), high titres of classical IgM rheumatoid factor and raised concentrations of circulating immune complexes. The study confirmed moreover the uncommon ocular toxicity related to the drugs frequently employed in RA treatment (antimalarials, gold salts, glucocorticoids). Indeed, only one case (4%) of posterior subcapsular cataract clearly related to steroid therapy was found.
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PMID:[Ocular involvement in rheumatoid arthritis]. 847 10

Systemic lupus erythematosus (SLE) is a chronic, immunologically mediated inflammatory connective tissue disorder with manifestations including various body organs (joints, pleura, pericardium, kidneys, brain, skin), caused by accumulation of immune complexes. According to epidemiological data SLE affects 0.12% of the population worldwide, while in Poland the number of reported cases is c. 60 000 - 80 000. SLE may also involve the eye. Anterior segment findings include keratoconjunctivitis sicca, keratitis and scleritis. Retinal manifestations of SLE are cotton wool spots, hemorrhage and vasculitis. The ARA (American Rheumatism Association), criteria are used in establishing the diagnosis of SLE. Although the ocular symptoms are not included in the ARA criteria, they may be initial findings and precede other manifestations of SLE.
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PMID:[General and ocular symptoms in systemic lupus erythematosus (SLE)]. 1768 18