Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022575 (
keratoconjunctivitis sicca
)
772
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aquaporins (AQPs) and the
cystic fibrosis transmembrane conductance regulator
(
CFTR
) provide the molecular routes for transport of water and chloride, respectively, through many epithelial tissues. In ocular epithelia, fluid transport generally involves secondary active chloride transport, which creates the osmotic gradient to drive transepithelial water transport. This review is focused on the role of AQPs and
CFTR
in water and ion transport across corneal/conjunctival epithelia, corneal endothelium, ciliary epithelium, and retinal pigment epithelium. The potential relevance of water and chloride transport to common disorders of ocular fluid balance is also considered. Recent data suggest AQPs and
CFTR
as attractive targets for drug development for therapy of
keratoconjunctivitis sicca
, recurrent corneal erosions, corneal edema, glaucoma, retinal detachment, and retinal ischemia.
...
PMID:Aquaporins and CFTR in ocular epithelial fluid transport. 1686 75
