Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022575 (keratoconjunctivitis sicca)
 772 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relevance of antibodies for La(SSB) as a marker of a distinctive systemic lupus erythematosus (SLE) subset was studied in 185 lupus patients. Anti La was detected in 39 (21%) and was accompanied invariably by anti Ro. Clinically, anti La-positive patients were distinguished by a later age of disease onset, and a low frequency of lupus nephritis. In common with other anti Ro-positive patients they showed a high frequency of keratoconjunctivitis sicca. Anti La identified patients with higher titres of anti Ro antibodies and was significantly associated with HLA-DR3. Serological markers such as these are useful for identifying more homogeneous populations of SLE patients for studies of aetiology and pathogenesis.
 ...
PMID:Anti La(SSB) identifies a distinctive subgroup of systemic lupus erythematosus. 325 99

In systemic lupus erythematosus (SLE), ocular involvement is common (prevalence up to 30%) but extremely varied.The most common manifestation is keratoconjunctivitis sicca (in about 25%). Though posterior segment disease is not uncommon, choroidal involvement and optic neuropathy are rare. Visual loss from neuro-ophthalmic involvement is often due to lupus optic neuropathy. Less than five percent of patients only present with sole ocular involvement at diagnosis. We report two patients who presented with decreased visual acuity and rare posterior eye changes as presenting features of SLE in the absence of other clinical manifestations and later developed lupus nephritis.
 ...
PMID:Rare Ocular Manifestations of Systemic Lupus Erythematosus--Two Case Reports. 2628 84