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Query: UMLS:C0022575 (keratoconjunctivitis sicca)
 772 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Histopathological study of filamentary keratitis was done by using replica technique in five patients. The filaments are produced by sliding of the epithelial cells around small areas of focal degeneration of the superfical epithelium. In comparison to the filaments in other conditions, the filaments in KCS are smaller and thicker and do not show the torsional segment. The filaments contain degenerated epithelial cells and alcian blue-PAS positive mucoid material. Making a corneal replica may result in healing of filamentary keratitis.
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PMID:Study of filamentary keratitis by replica technique. 38 Mar 83

Eight patients with severe keratoconjunctivitis sicca and filamentary keratitis requiring treatment with continuous wear bandage lenses and frequent instillation of artificial tears were studied. The lenses were removed after wear from 3 to 8 weeks and subjected to ultraviolet spectrophotometric evaluation for the presence of the preservative, benzalkonium chloride. No evidence of benzalkonium chloride in the lenses was seen and no clinical evidence of corneal damage was noted. The use of topical medication containing benzalkonium chloride as a preservative in conjunction with hydrophilic lens appears to be clinically acceptable.
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PMID:Bandage lenses and the use of topical solutions containing preservatives. 71 37

In our referral practice at the University of Florida, corneal exposure during sleep appears to be a relatively common cause of previously undiagnosed chronic keratitis. The spectrum of the disease ranges from minimal epithelial changes that may heal later in the day to severe exposure ulcers with marked loss of stromal substance. Keratitis sicca and previous lid abnormalities are predisposing factors, but not necessary concomitants of the disease. The diagnosis can usually be made by asking the patient to gently (not forcibly) close his eyes, and usually within a minute or two, a small crack can be seen between the lids by shining light on the intrapalpebral areas-during this time there is usually some fasciculation of the lids. In our experience the most effective treatment, when ointments at bedtime are not adequate, is closing the eye by using a piece of paper tape to pull up the cheek, and then attaching the tape to the forehead, with no pad or pressure on the eye. After the initial healing, ointments at bedtime may be adequate to maintain a symptom-free state in this apparently common cause of treatment-resistant chronic keratitis.
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PMID:Corneal exposure during sleep (nocturnal lagophthalmos). 84 76

A total of 209 pathological eyes each had 17 localities tested for sensitivity (cornea, caruncle, upper and lower lid margins (centrally, medially and laterally), and corresponding localities on the palpebral conjunctiva, and upper and lower halves of the bulbar conjunctiva). Reduced conjunctival sensitivity is seen in pemphigoid (excluding the lid margin) in contact lens wearers, at sites of nerves transected during operation and in rare cases of infectious conjunctivitis. Isolated corneal hypaesthesia is seen in bacterial or fungal keratitis. In herpes, the hypaesthesia extends over the bulbar conjunctiva, in zoster, over wider areas (including the lid margin). The sensitivity is normal in keratoconjunctivitis sicca and chronic conjunctivitis. In neurological diseases the hyposensitivity could include the cornea, conjunctiva and lid margin. The conclusion is drawn that a study of the conjunctivo-corneal sensitivity can give differential diagnostic information, provided the normal sensitivity range is known. This has been set out in a Table in 10-year age groups.
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PMID:Conjunctival sensitivity in pathological cases, with simultaneous measurement of corneal and lid margin sensitivity. 110 26

Peripheral ulcerative keratopathy and necrotizing scleritis have been reported in rheumatoid arthritis patients after cataract surgery, but the incidence of these complications during the immediate postoperative period is unknown. We retrospectively studied 70 patients with rheumatoid arthritis who underwent a total of 86 cataract extractions between 1973 and 1988. Only 15 of the patients had a preoperative history of keratoconjunctivitis sicca. The best corrected postoperative visual acuity was greater than or equal to 20/30 in 81% of eyes. No episodes of scleritis or peripheral ulcerative keratopathy occurred during the 8-week postoperative period. Three patients (all from the sicca group) developed diffuse superficial punctate keratopathy and/or filamentary keratitis. Results suggest that serious corneal complications after cataract surgery are uncommon in rheumatoid arthritis patients similar to the population found in our study (95% Poisson confidence interval 0-6.6%).
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PMID:Corneal complications after cataract surgery in patients with rheumatoid arthritis. 158 18

Sixty-seven patients undergoing allogenic bone marrow transplantation (BMT) were examined before and at regular intervals for up to 87 months (1-87 months, mean 18) after transplantation. Within a period of 1-39 months, 14 of these patients died (11 male, 3 female; age at BMT 16-46y). Five of these patients died within the first 100 days. They showed no eye involvement; three patients had intraretinal hemorrhage, in one case of squamous blepharitis and filiform keratitis developed during chronic graft-versus-host disease (GVHD). In contrast, 22 of 53 (41.5%) surviving patients (30 male, 23 female; age at BMT 1-47y) were found to have ocular involvement. Before BMT only two cases of retinal hemorrhage and central chorioretinal scars each were detected. During the stage of acute GVHD (up to day 100), nine patients were free of ocular manifestations. However, 16 of the 20 patients with chronic GVHD showed ocular involvement; 14 (70%) had reduced tearflow, ten had severe keratoconjunctivitis sicca, four suffered from sterile corneal ulcerations. Bilateral cataracts were detected in 11 patients, nine of whom only had minimal posterior subcapsular opacification, possibly resulting from highdose steroid medication. One additional case presented with bilateral multifocal recurrent chorioretinitis and panuveitis. The fundus lesions appeared some months after BMT (before cyclosporin-A treatment started) and recurred during systemic treatment. All patients undergoing allogenic BMT, especially when treated for severe chronic GVHD, require regular ocular observation to avoid complications such as keratoconjunctivitis sicca at an early stage, as late complications are often severe and hardly amenable to conservative or surgical treatment.
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PMID:Manifestations of graft-versus-host disease following allogenic bone marrow transplantation. 182 Nov 95

Infection by FHV-1 is one of the most common ophthalmic diseases of domestic cats worldwide. Although the usual manifestations are conjunctivitis and keratitis, infection with this virus has been linked to a variety of other ophthalmic syndromes of cats, including keratoconjunctivitis sicca and corneal sequestration. Ocular FHV-1 infection of cats provides a significant diagnostic challenge to the practicing veterinarian because, in chronic cases, antigen detection tests often yield negative results. Although therapy for FHV-1 infections of cats is often difficult, the recent development of nontoxic antiviral drugs that demonstrate considerable efficacy against FHV-1 offers hope for improved therapeutic success in the future.
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PMID:Feline herpesvirus ocular disease. 216 58

The authors studied the tear film and ocular surface in a rabbit model of neurotrophic keratitis to determine the extent to which the surface disease of neurotrophic keratitis resembled keratoconjunctivitis sicca. After denervation, tear film osmolarity increased and remained significantly elevated for 14 weeks. The ocular surface developed decreased conjunctival goblet cell density, decreased corneal epithelial glycogen, and morphologic changes similar to those seen in keratoconjunctivitis sicca. Although the conjunctival changes were consistent with the increases in tear film osmolarity and the surface disease of keratoconjunctivitis sicca, the corneal changes observed with denervation, including slit-lamp findings, morphologic changes, and decreases in glycogen, were too severe and rapid in onset to be accounted for by osmolarity alone. Neurotrophic "keratitis" is an ocular surface disease composed in part of the surface disease of keratoconjunctivitis sicca. However, the data also support an additional mechanism for corneal disease that could be due to the trophic influence of the trigeminal nerve.
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PMID:Tear film and ocular surface changes in a rabbit model of neurotrophic keratitis. 233 68

Evidence is presented which supports the centripetal movement of epithelial cells in the normal corneal epithelium. This movement is not, however, uniform and is influenced by various factors including corneal topography, surface disease states and lid shearing forces. We have studied epithelial morphology with corneal specular microscopy and have demonstrated altered morphology in keratoconjunctivitis sicca, neurotrophic keratitis, and contact lens wearing. Following penetrating keratoplasty, we found a vortex keratopathy in 70 per cent of patients up to two years after surgery. We also found pallisading of epithelial cells around sutures which indicated centripetal movement of epithelial cells around islands of stability created by obstructions. The eyelid also alters epithelial migration and turnover by increasing exfoliation from shearing forces. We advance a new hypothesis that the driving force in the central epithelial cell movement is the preferential loss of surface cells by exfoliation from the central apex secondary to the shearing forces of the upper lid.
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PMID:Corneal epithelial cell movement in humans. 260 18

Superficial stromal keratitis or pannus is a syndrome of corneal, conjunctival and third eyelid inflammation. Superficial stromal keratitis mainly presents as a subepithelial corneal infiltration of vascular connective tissue, and usually arises from the lateral (temporal) limbal area. In some dogs perilimbal hyperaemia and third eyelid blepharitis can be present without corneal involvement. The most commonly affected breed of dog is the German Shepherd. Most cases of superficial stromal keratitis can be controlled with topical corticosteroids, and only rarely is cryosurgery or superficial keratectomy required to remove excessive pigment and or granulation tissue. The precise aetiology of SSK is unknown, but is likely to be multifactorial, with sunlight being a significant factor. Corneal lipidosis and keratoconjunctivitis sicca can occur secondary to superficial stromal keratitis.
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PMID:Superficial stromal keratitis in the dog. 305 8


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