Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022575 (
keratoconjunctivitis sicca
)
772
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Keratoconjunctivitis sicca
is the major cause of chronic or recurrent conjunctivitis in dogs. The diagnosis of
KCS
is often delayed or mistaken for allergic or
bacterial conjunctivitis
and inappropriate or insufficient treatment leads to progressive corneal scarring and blindness in many dogs. The cause of
KCS
in dogs has not been proven, but evidence supports an immune-mediated etiology for the majority of cases. In an attempt to specifically treat the cause of
KCS
, a new immunosuppressant drug, cyclosporine, has been used in a topical preparation. Treatment results using ophthalmic cyclosporine are dramatic compared with historical treatments. Resolution of corneal scarring and increased lacrimation are seen in most dogs. Investigations of the mechanism of action of ophthalmic cyclosporine suggest the efficacy may have been serendipitous. A local neuroendocrine effect of cyclosporine on the lacrimal gland may actually be responsible for the increased lacrimation. Early diagnosis of
KCS
and treatment with ophthalmic cyclosporine may avert a major cause of blindness in dogs.
...
PMID:A new perspective on canine keratoconjunctivitis sicca. Treatment with ophthalmic cyclosporine. 219 49
