Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-five myopic subjects were fitted with rigid gas-permeable lenses for 6 months of extended wear (EW). These lenses had an average oxygen transmissibility of 37 x 10(-9) (cm x ml x O2)/(s x ml x mm Hg). For six monthly morning visits subjects reported with one eye patched; corneal thickness, corneal curvature, refractive error, endothelial photomicroscopy, and slitlamp examinations were done on both eyes. The average morning corneal swelling was 5.9 +/- 3.3%. Corneal curvature showed 0.24 +/- 0.44 D flattening in the steep meridian and 0.20 D steepening in the flat meridian. Spectacle refraction and corrected visual acuity changes were small in the spherical and cylindrical components. Complications that were important clinically included 10% lens adherence syndrome, 20% superficial limbal keratitis, 6.5% epithelial microcysts, and some increase in endothelial polymegathism. No infections, red eye responses, or infiltrative keratitis were observed during the 6-month follow-up period. These results suggest that hard-lens EW is feasible and that lenses with this Dk/L value will meet oxygen requirements for many patients; however, some patients will require lenses of higher oxygen transmissibility to avoid undesirable complications.
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PMID:Ocular effects of hard gas-permeable-lens extended wear. 316 5

After having photorefractive keratectomy (PRK), a 29-year-old man suffered from delayed epithelial healing and corneal stromal ring infiltrates. All laboratory results including smear, culture, and biopsy for bacteria, herpes simplex virus, and Acanthamoeba were negative. The suspected cause was patient abuse of anesthetics. Subsequently, it was discovered that for 6 months, since just after the PRK, the patient had intermittently used topical proparacaine drops. After all medication was discontinued and the eye pressure patched, the corneal epithelium healed completely. Practitioners should consider the possibility of topical anesthetic abuse in cases of keratitis after PRK.
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PMID:Keratitis from corneal anesthetic abuse after photorefractive keratectomy. 915 92