Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Proteolytic enzyme inhibitors are capable of preventing decomposition of the collagen structures of the corneal stroma, and also have a regulating influence on various aspects of the inflammatory process. The content of proteolytic enzymes (alpha 1-antitrypsin and alpha 2-macroglobulin) was studied in the tears and the blood serum of patients with herpes viral keratitis, as well as in the blood serum of rabbits with experimentally-induced ophthalmoherpes. Herpetic keratitis was attended by significant changes in the content of proteolysis inhibitors, as well as in the peripheral blood neutral proteases activity, this presumably serving as a nonspecific blood protective reaction to the inflammation. In the tears of patients suffering from herpetic keratitis the inhibitors are expended for binding activated proteases in the cornea. Local application to rabbits of protein preparations with an inhibitory effect (contrykal, gordox) at the acute period of the experimentally-induced ophthalmoherpes produced a marked antiphlogistic effect.
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PMID:Antiproteases in herpetic keratitis. 245 13

Alterations in content of main inhibitors of proteolysis alpha 1-antitrypsin and alpha 2-macroglobulin as well as activity of neutral proteases in blood serum were studied in herpetic impairment of human and rabbit retina. Unspecific protective reaction of the blood proteolytic inhibitors developed in ophthalmoherpes. In the acute period of the disease content of alpha 1-antitrypsin was increased and the content of alpha 2-macroglobulin was decreased. Slow development of the disease was observed when the content of alpha 1-antitrypsin was decreased at the period of acute inflammation. Estimation of proteolytic inhibitors might serve as an useful test for characteristics and prognosis of herpetic keratitis.
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PMID:[Main proteolytic inhibitors in ocular herpes]. 617 34

Eyes from autopsy cases of leprosy patients (29 eyes from 16 cases) were examined histologically. In some cases immunohistochemical methods were used. In the lepromatous type, ocular complications such as keratitis and iridocyclitis were often found. In the tuberculoid type, such complications were seldom encountered. In the active stage, lepra cells and "foamy cells" showed positive reaction to acid-fast staining and anti-BCG antibody but in the silent stage they did not react. All foamy cells in both the active and the silent stage showed positive reaction to KP1, but they did not react to lysozyme or alpha 1-antitrypsin. These results suggest that the foamy cells originated from macrophages, but that their biological activity was low.
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PMID:[Ocular histopathological studies in leprosy in the silent stage--I. Light microscopic feature]. 794 45