Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent advances in our understanding of the inflammatory response to Pseudomonas aeruginosa (P. aeruginosa)-induced keratitis have revealed a critical role for the cytokine interleukin (IL)-1beta in up-regulation of other cytokines/chemokines and promoting neutrophil (PMN) infiltration. Studies using antibody neutralization, knockout of caspase-1 (ICE), the enzyme that processes IL-1beta from the pro- to the active form, as well as use of an inhibitor of the enzyme, have provided evidence that decreasing levels of IL-1beta in the cornea improves disease outcome. When combined with antibiotic, the caspase-1 inhibitor provided better disease outcome than either the inhibitor or antibiotic alone, supporting the possibility of alternate therapy for this disease.
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PMID:Inflammatory response to Pseudomonas aeruginosa keratitis. 1721 3