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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We applied the direct immunoperoxidase method to estimate the susceptibility to IDU of 17 strains of the virus which were isolated from the patients with active epithelial lesions of herpetic keratitis. All the strains were found to be sensitive below the IDU concentration of 5 micrograms/ml. The findings obtained by this method were in good agreement with those by the fluorescent antibody technique. The present method is specific and simple. It offers clear-cut interpretation and a permanent record of the results.
Acta Ophthalmol (Copenh) 1983 Dec
PMID:Use of the immunoperoxidase technique for estimation of susceptibility of herpes simplex virus to IDU. 631 9

The spitting cobra (Naja nigricollis) can eject its venom into its adversary's eyes from a distance of several meters. This causes an immediate and painful conjunctival infection, followed by blepharospasm, corneal and conjunctival edema, and erosion. Corneal ulcer, in some cases with perforation, hypopyon and endophthalmitis are the results. The present paper reports on a 35-year-old patient from Hemkoa (South Upper Volta) whose eyes had been affected by the venom of a spitting cobra 5 years previously. The patient had meanwhile lost his sight as a result of bilateral sclerosing keratitis. The possible influence of the patient's basic disease (onchocerciasis) on the course of the sclerosing keratitis is discussed.
Klin Monbl Augenheilkd 1984 Dec
PMID:[Spitting cobra ophthalmia (Naja nigricollis)]. 633 38

Fifty-nine patients with superficial herpetic keratitis were treated with 3% acyclovir ointment five times a day in combination with alpha-interferon (30 million IU/mL) or albumin-placebo once a day in a stratified double-masked clinical trial. All patients had minimal wiping of the superficial lesion to isolate virus. The healing time of the corneal ulcers was substantially lower with the combination of acyclovir and interferon than with the combination of acyclovir and placebo. Only minor toxic effects were observed. The combination of acyclovir and interferon appears to be the best presently known treatment for dendritic keratitis.
Arch Ophthalmol 1983 Dec
PMID:Combination therapy for dendritic keratitis with acyclovir and alpha-interferon. 636 Jan 10

K-582, a new basic peptide antibiotic, was tested in rabbits with experimental Candida keratitis. It was shown that the K-582-treated group showed statistically highly significant therapeutic effects on days 2 and 3, as compared with the control group (day 2: P less than 0.001; day 3: P less than 0.001). The culture study showed that the average number of colonies was 1,573.1 in the controls and 463.3 in the treated group, and the difference was highly significant statistically (P less than 0.001). No ocular or systemic toxic effects were observed with this drug. K-582 is a promising new drug for the treatment of Candida keratitis.
Invest Ophthalmol Vis Sci 1983 Dec
PMID:The effect of K-582, a new antifungal agent, on experimental Candida keratitis. 636 Sep 48

The causes of blindness in Sierra Leone were studied in 7286 new patients attending the eye clinic in the year 1981. Blindness, defined as an inability to count fingers at 3 meters with the better eye (WHO, 1973), was present in 762 persons, due to cataract (39%), ocular onchocerciasis (30%), primary glaucoma (8%), measles keratitis (3%), trachoma (3%) and other causes. The prevalence of blindness was estimated from simple field surveys covering 41 villages with an estimated population of 10,559. The average prevalence of blindness was found to be 1.3% of the total population.
Doc Ophthalmol 1983 Dec 15
PMID:Causes and prevalence of blindness in the Northern Province of Sierra Leone. 666 98

Thirty-five patients with long-standing deep stromal herpes simplex keratitis were treated with 3% acyclovir ointment and corticosteroids. All patients were cured in 2 to 4 weeks, independent of both the duration of the keratitis before acyclovir therapy and the previous antiviral medication. Corticosteroids in tapering dosages had to be continued for many months after healing to prevent recurrence of stromal corneal oedema; recurrences could not be prevented by acyclovir therapy. No serious side-effects of acyclovir were noted.
Doc Ophthalmol 1983 Dec 15
PMID:Acyclovir treatment in stromal herpetic keratitis. 666 13

In severe zoster keratitis many pathogenic factors are involved. In addition to viral manifestations, the cornea is often affected by anterior uveitis or secondary glaucoma. Neuroparalytic keratitis causes lowered blinking frequency and decreased tear secretion. In addition, zoster ulcerations of the upper lid margin mechanically disturb reformation of the tear film and weaken the lipid layer by necrosis of the Meibomian glands. Ointments reduce break-up time and parasympathicolytic mydriatics further decrease tear secretion. When the average time between two blinks is shorter than the tear film break-up time, a "dry eye" condition usually develops. The appropriate treatment in such cases is thorough prevention of evaporation.
Klin Monbl Augenheilkd 1980 Dec
PMID:[Diagnosis and treatment of neuroparalytic zoster keratitis (author's transl)]. 697 Aug 53

The authors report on a disease of the cornea resembling keratitis nummularis developed by patients wearing Hema lenses. The large disk-shaped subepithelial opacities are accompanied by pathologic changes in the endothelium of the peripheral parts of the cornea. Etiologically, it is believed that there is an immunologic process acting on components of the lenses and the solutions they are cleaned with and kept in. The differential diagnosis between Dimmer's nummular keratitis, epidemic keratoconjunctivitis and herpetic corneal diseases in discussed.
Klin Monbl Augenheilkd 1981 Dec
PMID:[Differential diagnosis of corneal changes in wearers of Hema lenses (author's transl)]. 697 56

In a masked controlled study, we treated 41 patients who had active herpes simplex corneal ulcers with either 3% acyclovir of 3% vidarabine ointment five times daily for 14 days. There was no statistically significant difference between the two drugs with reference to mean healing time, efficacy of healing, development of stromal keratitis or iritis, post-treatment visual acuity, or adverse reaction.
Am J Ophthalmol 1981 Dec
PMID:Acyclovir and vidarabine in the treatment of ulcerative herpes simplex keratitis. 703 3

A healthy 48-year-old man developed Aspergillus keratitis following mild corneal trauma. Intensive medical therapy, initially empirical, then guided by in vitro sensitivity testing, as well as attempts at surgical excision of the infection, were ultimately unsuccessful. The poor therapeutic response may have been due to fungal penetration of the deep corneal stromal before treatment was initiated. The clinical and histologic features of A keratitis are described and related to fungal keratitis in general. The strengths and limitations of laboratory diagnostic aids are discussed. Fungal keratitis may follow a disarmingly mild early clinical course, but requires prompt, aggressive therapy if serious complications are to be avoided.
Ophthalmology 1981 Dec
PMID:Aspergillus keratitis with intraocular invasion. 703 54


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