Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Polyvinylpyrrolidone-iodine (PVP-I) is a biocompatible broad spectrum antimicrobial that is widely used as an ophthalmic pre-operative prepping agent. In order to determine if PVP-I is safe for treating corneal ulcers and conjunctivitis, we evaluated the ocular toxicity of frequent dosing in a rabbit model. We evaluated ocular irritation in 18 rabbits according to the McDonald-Shadduck method. Concentrations of 0.5% PVP-I or less were practically non-irritating when administered six times per day. We evaluated corneal epithelial wound healing in 16 rabbits with standardized abrasions. Concentrations of 0.33% PVP-I showed epithelial healing comparable to gentamicin treated eyes and untreated controls. Concentrations of 0.5% PVP-I delayed epithelial healing by one day. Because of its broad spectrum and apparently low toxicity, PVP-I may be a useful treatment for corneal ulcers, keratitis and conjunctivitis.
 ...
PMID:Polyvinylpyrrolidone iodine: corneal toxicology and epithelial healing in a rabbit model. 324 70

Ocular films of pefloxacin mesylate were prepared with the objectives of reducing the frequency of administration, to improve patient compliance, obtaining controlled release and greater therapeutic efficacy in the treatment of eye infections such as conjunctivitis, keratitis, kerato conjunctivitis, corneal ulcers etc. Polymers such as HPC, HPMC, PVP and PVA were used in different ratios to prepare the ocular films. They were evaluated for drug content which varied from 96-104%. Those which consisted of flexible and transparent films were subjected to in vitro release studies. The formulations which prolonged the release for eight hours were selected. The average weight and thickness of these were found to be 38.92-49.71 mg and 31.68-46.08 microns, respectively. The intactness of the formulations was confirmed by IR and TLC studies. In vivo studies carried out in the eyes of rabbits showed controlled release upto 8-9 h. There was a good correlation between the in vitro and in vivo data (r = 0.97-0.995). A minimum of 1 Mrad was found to be necessary for the sterilization of ocular films by gamma radiation. They were found to be stable at temperatures below 45 degrees C.
 ...
PMID:Ocular delivery systems of pefloxacin mesylate. 998 97