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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty eyes in 20 patients with herpetic keratitis were treated with excimer laser photoablation. Sixteen eyes underwent phototherapeutic keratectomy because of scars and surface irregularities, with the goal to improve vision and 1 eye for cosmetic reasons. Two eyes had slight scars but were treated because of a refractive error (PRK). One eye had a metaherpetic ulcer where the wound surface was ablated with the intention to improve healing. Twelve of the 16 eyes showed improved visual acuity of 2 lines or more on the Snellen chart. The refractive outcome was acceptable in the 2 PRK eyes. The cosmetic result was good and the metaherpetic wound epithelialized within 3 weeks. Of the 20 patients 5 had 1 or more recurrences during the 16.8 months of follow-up. In the 17 months preceding the laser surgery 9 eyes had 1 or more recurrences. Three of these eyes still showed improved vision. Phototherapeutic excimer laser surgery is advantageous in selected cases and should be considered before corneal grafting. The procedure does not seem to increase the incidence of recurrences.
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PMID:Phototherapeutic keratectomy in herpes simplex keratitis. Clinical results in 20 patients. 782 12

Corneal wound healing makes important contributions to the outcomes of both traditional excimer laser ablation procedures and custom corneal ablations and contributes to the poor predictability of keratorefractive surgery in some patients. In addition, wound healing makes important contributions to some complications of PRK, LASEK or LASIK,including haze and diffuse lamellar keratitis. Detailed characterization of the wound healing cascade that occurs following refractive procedures is fundamental to pharmacological and molecular approaches for controlling or normalizing the response to surgery,thereby reducing biological diversity in variables such as epithelial hyperplasia and stromal remodeling that often tend to mask attempts at custom ablation.
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PMID:Corneal wound healing relevance to wavefront guided laser treatments. 1520 64

Simultaneous corneal cross-linking (CXL) has been proposed as an adjunct therapy to corneal refractive procedures to prevent future ectasia, especially when performed in borderline corneas. This review analyses the currently available literature (minimum follow-up 6 months) on corneal refractive surgery and simultaneous CXL (PRK Xtra, LASIK Xtra, and SMILE Xtra) to evaluate the overall results including the safety, efficacy, and potential complications associated with these procedures. A comprehensive literature search of various electronic databases (PubMed, PubMed Central, Cochrane database, and MEDLINE) was performed up to 20th May 2020. Four relevant studies were found for PRK Xtra, 12 for LASIK Xtra, and 3 for SMILE Xtra. The total number of eyes included in this review was 1,512: 294 for PRK Xtra, 221 for PRK-only, 446 eyes for LASIK Xtra, 398 eyes for LASIK-only, 91 for SMILE Xtra and 62 for SMILE-only. Current literature suggests that refractive surgery and simultaneous CXL is generally safe and delivers comparable results in terms of visual and refractive outcomes than refractive surgery alone. However, there is no consensus on a standard cross-linking protocol, and complications such as diffuse lamellar keratitis, central toxic keratopathy, and corneal ectasia following Xtra procedures have been reported. It is therefore suggested that surgeons exercise caution in case-selection and counsel their patients regarding the potential risks and benefits with Xtra procedures. Also, further studies are required to standardize the UV-A irradiation protocols and to evaluate the long-term effect on safety, refractive predictability, and stability of these procedures.
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PMID:Refractive surgery with simultaneous collagen cross-linking for borderline corneas - A review of different techniques, their protocols and clinical outcomes. 3322 50