Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Activities of glutathione peroxidase, lactate-, malate- and glutamate dehydrogenases were decreased, while glucose-6-phosphate dehydrogenase was activated in peripheric blood lymphocytes of patients with herpetic keratitis within the acute period. Alterations in the enzymatic activity were especially distinct in herpetic ulcer of sclera as compared with other clinical forms of herpetic keratitis. As lymphocyte oxidoreductases responded distinctly to herpetic infection, estimation of their activity could be used for diagnosis, prognosis and monitoring of herpes treatment.
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PMID:[Oxidoreductase activity of peripheral blood lymphocytes of patients with herpetic keratitis]. 366 Jul 41

Melatonin synthesis occurs in the retina of most animals as well as in humans. Circadian oscillators that control retinal melatonin synthesis have been identified in the eyes of different animal species. The presence of melatonin receptors is demonstrable by immunocytochemical studies of ocular tissues. These receptors may have different functional roles in different parts of the eye. In view that melatonin is a potent antioxidant molecule, it can be effective in scavenging free radicals that are generated in ocular tissues. By this mechanism melatonin could protect the ocular tissues against disorders like glaucoma, age-related macular degeneration, retinopathy of prematurity, photo-keratitis and cataracts. Although an increased intraocular pressure is an important risk factor in glaucoma, other concomitant phenomena like increased glutamate levels, altered nitric oxide metabolism and increased free radical generation seem to play a significant role in its pathogenesis. Data are discussed indicating that melatonin, being an efficient antioxidant with antinitridergic properties, has a promising role in the treatment and management of glaucoma.
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PMID:Melatonin in the eye: implications for glaucoma. 1717 3