Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experimental Acanthamoeba keratitis was induced in Wistar rats by intrastromal inoculation of Acanthamoeba polyphaga cysts. Keratitis developed in all corneas injected and was characterised by a diffuse granular opacity. The animals were examined for 70 days and a gradual reduction of keratitis was observed. Pathological sections showed liquefactive stromal necrosis and Acanthamoeba localised in deep stroma persisting to 70 days. A brisk inflammatory infiltrate of neutrophils and macrophages was seen in the early days of infection. Severity of keratitis was found to correlate with inflammatory activity in pathological sections. The uses of an animal model of Acanthamoeba keratitis are described.
Br J Ophthalmol 1990 Sep
PMID:Experimental Acanthamoeba keratitis: I. Preliminary findings. 239 46

A 35-year-old physician had radial keratotomy (RK) for correction of myopia. Combined radial and transecting circumferential incisions were used which resulted in wound gape, persistent epithelial defect, and severe sterile keratitis. Progressive corneal decompensation required an initial patch graft followed by a penetrating keratoplasty four months after RK. Histopathology of the cornea demonstrated epithelial edema and persistent incisional epithelial plug formation, deep and superficial vascularization, variable incision depth (superficial to full thickness), endothelial cell loss, and inflammatory cell infiltration at all levels of the cornea. A review of the reported complications of RK is included in the discussion of this case.
Ophthalmology 1985 Sep
PMID:Radial keratotomy complicated by sterile keratitis and corneal perforation. Histopathologic case report and review of complications. 241 6

Two soft contact lens wearers using a homemade saline solution developed corneal stromal inflammation and epithelial ulceration and were both treated for months with a presumptive diagnosis of herpes simplex keratitis. Subsequently, corneal scrapings revealed refractile, cystic structures consistent with the appearance of Acanthamoeba. This was rapidly confirmed by indirect fluorescent antibody studies, and Acanthamoeba castellani was later identified by growth in culture in both cases. Acanthamoeba is being reported with increasing frequency as a pathogen responsible for chronic stromal keratitis and ulceration in contact lens wearers. Since specific therapy is required to control this organism, rapid diagnosis is essential. Indirect fluorescent antibody staining of corneal scrapings provides a simple means of accomplishing this goal with a high degree of accuracy.
Arch Ophthalmol 1986 Sep
PMID:Rapid diagnosis of Acanthamoeba keratitis from corneal scrapings using indirect fluorescent antibody staining. 242 44

The intrastromal implantation of Concanavalin A-stimulated allogeneic lymphocytes induced corneal neovascularization (CNV) in inbred C57BL/6 and BALB/c mice. Control syngeneic stimulated, allogeneic non-stimulated, and allogeneic stimulated irradiated lymphocytes were not angiogenic. CNV induced by allogeneic stimulated lymphocytes in BALB/c recipients was significantly greater than in C57BL/6 recipients. This response reflected host-versus-graft reactivity, since parental recipients responded to F1 hybrid donors, while F1 hybrids did not respond to parental donors. The ability of stimulated lymphocytes to induce CNV may be important in allograft rejection, herpes simplex keratitis, and other corneal immune reactions. The mouse cornea is an excellent model for studying immunologically mediated neovascularization under genetically controlled conditions.
Invest Ophthalmol Vis Sci 1987 Sep
PMID:Corneal neovascularization induced by stimulated lymphocytes in inbred mice. 244 16

We studied the effect of minimal antibiotic therapy on pseudomonas keratitis in rabbits. Both corneas of 12 rabbits were infected with Pseudomonas aeruginosa and treated 24 and 48 h later with two drops of tobramycin or placebo. Corneal infections in antibiotic- and placebo-treated groups were comparable in appearance 24 and 48 h after inoculation. However, bacterial recovery was significantly less in eyes treated with minimal antibiotic therapy (p = 0.009). Although negative cultures were obtained from 11 of 12 antibiotic-treated eyes, bacteria could be recovered from eight of these culture negative corneas when corneas were ground and cultured. These studies suggest that minimal antibiotic therapy may impair bacterial recovery without completely eradicating live organisms.
Cornea 1989 Sep
PMID:Effect of minimal antibiotic treatment on bacterial keratitis. 250 Oct 67

The activity of red-cell C3b receptor and the level of circulating immuno-complex in 35 cases of herpes simplex stromal keratitis were determined, with the results that during the stage of acute attack, the former was significantly lowered, while the level of the latter became markedly higher than that of the controls, and after treatment, the indicators returned to normal values. There was a negative correlation between the red-cell C3b receptor activity and the circulating immuno-complex in serum, indicating that the immuno-function of red-cells in patients with herpes simplex stromal keratitis was impaired and the depression of red-cell C3b receptor activity was one of the reasons for the elevated concentration of circulating immuno-complex in serum.
Zhonghua Yan Ke Za Zhi 1989 Sep
PMID:[Activity of the red-cell C3b receptor and the circulating immuno-complex in patients of herpes simplex keratitis]. 253 77

A method is introduced for the analysis of community patterns of ocular onchocerciasis in relation to the intensity of infection as measured by the Community Microfilarial Load (CMFL). Specific features of this method are the clear definition of ocular lesions and their separation into early and advanced stages, and the estimation of the prevalence of onchocercal blindness after exclusion of other causes of blindness. The method is applied to the ophthalmological and parasitological data from 33 villages from the West African savanna in order to obtain a reference pattern for subsequent analyses of ocular onchocerciasis patterns from other bioclimatic zones. In the savanna, there exists a clear linear relationship between most indices of ocular onchocerciasis and the CMFL. Mean ocular microfilarial loads, prevalences of the advanced lesions of the anterior and posterior segment of the eye and prevalences of different classifications of blindness show a high degree of correlation with the CMFL, as does also early sclerosing keratitis. The correlation is poor for the other early ocular lesions. All relationships are similar for the two sexes with the exception of posterior segment lesions which remain more common in males after correction for intensity of infection. The CMFL is superior to the prevalence of microfilariae in the skin as an index of endemicity. It allows a good prediction of the severity of onchocercal ocular disease in savanna communities using parasitological information only.
Trop Med Parasitol 1989 Sep
PMID:Ocular onchocerciasis and intensity of infection in the community. I. West African savanna. 261 45

An epidemiological survey of blindness and low vision in Chongqing showed that in a random sample of 13,832, there were 62 cases of bilateral blindness and 97 cases of bilateral low vision, the prevalences being 0.45% (male 0.38%, female 0.52%) and 0.70% (male 0.50%, female 0.90%) respectively. The prevalences in people over 60 years of age were significantly higher. The important blinding diseases were cataract, infectious keratitis, corneal turbidity, glaucoma, trachoma, and ametropia/amblyopia.
Zhonghua Yan Ke Za Zhi 1989 Sep
PMID:[An epidemiological survey of blindness and low vision in Chongqing]. 263 8

Unlike Corynebacterium diphtheriae and Propionibacterium acnes, the pleomorphic gram-positive rods known as diphtheroids are generally regarded as nonpathogenic contaminants of the human external eye. We reviewed five years of microbiology records at Wills Eye Hospital and studied a series of eight cases of apparently infectious keratitis associated with heavy growth of diphtheroids on cultures of ulcer scrapings. All of these cases included indolent ulcers that occurred almost exclusively in elderly patients (mean age, 72 years; range, 11 to 92 years). All patients had preexisting ocular conditions that compromised the corneal surface such as exposed corneal sutures, eyelid surgery, aphakic extended wear contact lenses, viral keratitis, and diabetes mellitus. No other pathogens were isolated. All infections responded well to antibiotic therapy with all organisms sensitive to cefazolin and all but one sensitive to gentamicin.
Am J Ophthalmol 1989 Sep 15
PMID:Diphtheroids as ocular pathogens. 277 33

Conjunctivitis has many bacterial and viral causes. If the cause is bacterial, treatment with a broad-spectrum antibiotic resolves the problem in 1 to 3 days in almost all cases. If signs and symptoms persist, referral to an ophthalmologist is wise. Most cases of viral conjunctivitis are accompanied by follicular reactions in the inferior fornix, as observed with adult inclusion disease. If dendrites are seen, trifluridine (Viroptic) is preferred for treatment. Referral to an ophthalmologist is advisable because recurrence with scarring and permanent loss of vision is possible. Many topical antibiotics include a corticosteroid component that never should be used unless the conjunctivitis or keratitis is proven to be nonherpetic.
Postgrad Med 1989 Sep 15
PMID:Viral and bacterial conjunctivitis. Prevention of disastrous results. 278 Apr 35


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>