Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The purpose of the study was to develop a procedure for predicting a relapse of herpetic keratitis in children, by taking into account the results of tear biochemical analysis. The tears from 47 children with herpetic keratitis were examined for the levels of total protein, the concentration of acute-phase proteins, such as orosomucoid and C-reactive protein, the activities of transferases: gamma-glutamyltranspeptidase transferase, aspartate aminotransferase, and alanine aminotransferase, those of lysosomal glycosidases: alpha-mannosidase, beta-glycosidase, and beta-glucuronidase. Tear biochemical assay made it possible to evaluate the efficiency of treatment and to develop a procedure for predicting a recurrence of herpetic keratitis in children. Determination of the tear activity of the glycosidases may be used to predict recurrent herpetic keratitis in children.
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PMID:[Use of tear enzyme assay to predict recurrent herpetic keratitis in children]. 1780 56

To specify mechanisms of pathology development, we studied the activity of lysosomal glycosides in rabbit ocular tissues in experimental ophthalmoherpes. Rabbits with herpetic kepatitis show activation of beta-glucuronidase, beta-glycosidase, alpha-mannosidase in cornial epithelium and stroma, iris, aqueous humor of herpes-infected and contralateral eye. The activity of the above three glycosidases in the tears of children with herpetic keratitis was enhanced. If their activity does not regress after the treatment, ophthalmoherpes recurrence may be expected in the near future. For realization of its genetic program herpes simplex virus in infected cells activates synthesis of acid glycosidases this leading to degradation of cornial cell membranes, virus spread in the tissues and release of lysosomal enzymes into tear fluid.
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PMID:[Pathogenesis of ophthalmoherpes basing on the analysis of enzymes of the eye tissue and fluids]. 1872 Jul 21