Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 1-year clinical study was performed on 257 consecutive patients with eye injury admitted in Muhimbili Medical Centre from January 1993 to January 1994. It describes the causes, presenting visual acuity and associated ocular complications, use of traditional eye medicine on the injured eye and lastly the visual outcome. Patients were classified into perforating and non-perforating injury patients. Stones, sticks and metallic objects were the major causes of ocular trauma. The main types of traditional medicines used were plant juices, milk mixed with black powder and pounded roots. The route of application was mainly instillation into the conjunctival sac. Traditional eye medicines were used by 49% of all patients. The main ocular complications presented keratitis, endophthalmitis and panophthalmitis were seen more in patients with a positive history of using traditional eye medicines than those with a negative history. Poor visual outcome was also seen more in patients who used traditional eye medicines than in those who did not use them. The use of traditional medicines on the injured eye is likely to be associated with a very poor visual outcome. It is thus, recommended that intensive health education be provided to create awareness in the community of the dangers of using traditional medicine on injured eyes. It is also recommended to integrate traditional healers into the modern health system in order to use their psychotherapeutically useful abilities and control their practices.
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PMID:Visual impact of using traditional medicine on the injured eye in Africa. 969 64

A 1-year hospital-based study was undertaken on 212 patients at Muhimbili Medical Centre (MMC) from October 1994 to October 1995. The objective was to determine the aetiology of corneal ulceration. A comparison of the prevalence of HIV infection between patients with fungal keratitis and those with non-fungal keratitis was included. Bacterial infection (32.1%), and mycotic infection (15.1%) were the leading causes of corneal ulceration. There were 32 patients with fungal keratitis and 180 patients with non-fungal keratitis. The male:female ratio for patients with fungal keratitis was 1.7:1 and the peak age group was 20-50 years. Fusarium solani was the commonest organism accounting for 75% of cases with fungal keratitis. Twenty of 32 (81.2%) cases with fungal keratitis were found to be HIV positive; 33% of those with non-fungal keratitis were HIV positive (P-value was < 0.001).
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PMID:Fungal keratitis as an indicator of HIV infection in Africa. 1044 32

A 1.5-year-old, intact female khaki Campbell duck (Anas platyrhynchos domesticus) was evaluated for lethargy and a swollen left eye (OS). Mucoid discharge, chemosis, and conjunctival hyperemia with trace aqueous flare, indicating anterior uveitis, in the anterior chamber were evident on ophthalmic examination. There was no fluorescein stain uptake by the cornea. Initial topical antibiotic therapy and systemic anti-inflammatory treatments were unsuccessful, and the lesion progressed to a diffuse, yellow-white plaque, which covered 90%-95% of the cornea 4 days later. There was moderate blepharospasm, mild blepharedema, and epiphora OS. The mobility of the nictitating membrane was impaired because of the presence of the plaque over the cornea. Cytologic examination of a corneal scraping revealed fungal hyphae, and aerobic culture confirmed Aspergillus species. Treatment with topical voriconazole (1 drop OS q4h-q6h) was initiated and was switched to oral voriconazole (20 mg/kg PO q12h) 6 days after initiating treatment. The ocular disease improved during the antifungal treatment period. Eighty-four days after initial presentation (9 days after discontinuation of treatment), there was no clinical evidence of mycotic keratitis on ophthalmic examination.
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PMID:Mycotic Keratitis in a Khaki Campbell Duck ( Anas platyrhynchos domesticus). 2584 71