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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pseudomonas keratitis in rabbit eyes was treated with Gentamicin and Tobramycin. There was no statistically significant difference between these antibiotics in the elimination of bacteria and regression of keratitis. The clinical results, however, were better in the Tobramycin group.
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PMID:[Treatment of Pseudomonas aeruginosa keratitis with tobramycin and gentamicin: animal experiments (author's transl)]. 723 Jul 15

Seventy-three aerobic bacterial isolates were cultured from 64 eyes of 63 horses with infectious keratitis. Forty-two (58%) of the organisms isolated initially were gram-positive (g+, 10 genera) and 31 (42%) were gram-negative (g-, 5 genera). After local antimicrobial treatment, repeat cultures from samples obtained from 15 eyes of hospitalized horses yielded 21 secondary bacterial isolates. Staphylococci spp and Streptococci spp were the most common g(+) isolates and accounted for 79% of g(+) organisms isolated initially. Antibiograms revealed ticarcillin to be the most efficacious antibiotic tested on g(+) organisms, with 28 of 30 (93%) being susceptible. Of commercially available topical ophthalmic antibiotics tested on g(+) organisms, erythromycin was the most efficacious, with 32 of 35 (91%) isolates being susceptible. Pseudomonas spp, Escherichia coli, and Acinetobacter spp accounted for 68% of g(-) organisms isolated initially. Gentamicin, tobramycin, polymyxin B, and neomycin were highly effective in vitro against initial g(-) isolates. Chloramphenicol was ineffective against g(+) and g(-) organisms isolated initially. A significantly (P < 0.05) higher frequency of g(-) organisms was noticed on repeat cultures after intensive topical antimicrobial treatments as compared to organisms isolated at initial examination. Pseudomonas organisms isolated from second cultures were resistant to gentamicin, but susceptible to ciprofloxacin. Overall, secondary g(-) isolates were more susceptible to ciprofloxacin, neomycin, tobramycin, or amikacin than to gentamicin. Fungi were isolated in 24 of 63 (38%) horses in the study. Twenty-five filamentous fungi and 2 yeasts were identified from 24 eyes.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Antibacterial susceptibility patterns for microbial isolates associated with infectious keratitis in horses: 63 cases (1986-1994). 755 27

We have previously shown the pharmacokinetic value of delivering gentamicin to the rabbit anterior segment using the Morgan Therapeutic Lens. The present study utilized an intrastromal injection model of Pseudomonas keratitis to test the therapeutic efficacy of continuous flow delivery of gentamicin with the Morgan therapeutic lens. All eyes (n = 52) received an intrastromal injection of approximately 1800 colony forming units (CFU) of Pseudomonas aeruginosa. At 22 hours after injection, eyes were perfused for 6 hours with saline or gentamicin (1, 2.5 or 5 mg/ml), or received gentamicin drops (13.6 mg/ml) at 15 minutes for four doses, then hourly for 6 hours. Corneas were homogenized and plated to determine bacterial survival, and expressed as log colonies (CFU). Log CFU recovered were 7.37 +/- 0.04, 6.64 +/- 0.20, 5.64 +/- 0.31, and 3.56 +/- 0.50 log CFU for saline perfusion, 1, 2.5, 5 mg/ml gentamicin perfusion respectively. Following six hours of treatment with topical fortified gentamicin drops, 5.93 +/- 0.34 log CFU were recovered. Gentamicin perfusion (5 mg/ml) was significantly different from saline or the other treatment groups (P < 0.05). Continuous corneal perfusion with the Morgan Therapeutic Lens demonstrated an increasing dose response curve with increasing perfusate concentration. It was effective in the treatment of experimental Pseudomonas keratitis.
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PMID:Continuous flow perfusion of gentamicin with a scleral shell reduces bacterial colony counts in experimental Pseudomonas keratitis. 822 34

The aim of this study was to determine the causative factors, organisms and antibiotic resistance in patients with bacterial keratitis in Singapore. We analysed retrospectively 103 cases of bacterial keratitis admitted to the Singapore General Hospital or the Singapore National Eye Centre during a 21-month period from March 1992 to December 1993. Contact lens wear represented the largest single predisposing factor (35 eyes, 34.0%), followed by ocular trauma (28 eyes, 27.2%) and pre-existing ocular disease (28 eyes, 27.2%). Thirteen of the twenty-eight cases of trauma-related keratitis were work-related injuries. Gram-negative organisms formed the largest group (41 cultures, 80.4%), with Pseudomonas aeruginosa being the most common organism identified (30 eyes). Pseudomonas was also responsible for 78.6% of all contact lens ulcers (11 out of 14 eyes). Resistance to gentamicin was only encountered in 1 case of Proteus mirabilis keratitis. All cases of Pseudomonas infection and 3 of the 10 Gram-positive cases were also resistant to chloramphenicol. All Gram-positive cases were sensitive to cephalosporins. Contact lens wear and ocular trauma are the major preventable risk factors for bacterial keratitis in young sighted eyes in Singapore. Gentamicin continues to be the antibiotic of choice for Gram-negative corneal infections in view of the low incidence of resistance. The routine use of chloramphenicol as the topical antibiotic of choice for corneal infection is not recommended due to the high resistance in Gram-positive and Gram-negative organisms locally.
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PMID:Corneal ulcers in two institutions in Singapore: analysis of causative factors, organisms and antibiotic resistance. 883 89