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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Purpose To compare the management outcome of endophthalmitis with and without the usage of topical antibiotics Methods Retrospective comparative chart review of two cohorts of endophthalmitis (other than those associated with open-globe injury, keratitis or wound site infection), one managed with (TA) and one without topical antibiotics (NTA). Results The study included a total of 270 eyes of 270 patients. Of these, 169 eyes were in the TA group and 101 eyes were in the NTA group. Males accounted for 56.8% and 53.8% respectively, p=0.59. Post cataract surgery was the commonest etiology accounting for 81.06% and 78.2% cases respectively, p=0.57. Favorable functional outcome at the last visit was seen in 37.5% and 39.6% eyes, p=0.73, respectively. Favorable anatomic outcome was noted in 61.2% and 49.5% eyes, p=0.06, respectively. Median follow up was 3.5 months and 9 months respectively, p<0.0001. Susceptibilities to common antibiotics used (vancomycin, ceftazidime and amikacin were comparable except for imipenem where the susceptibility noted was 95% and 66% respectively, p=0.01. Culture positivity in the TA group was seen in 72/169 (42.6%), while in the NTA was seen in 98/101 (97.02%) p<0.0001. Conclusion Topical antibiotics do not give any added advantage in the management of endophthalmitis otherwise being treated with intravitreal antibiotics and standard vitrectomy techniques.
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PMID:Management of endophthalmitis with and without topical antibiotics : A case-control study. 3233 57