Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022568 (
keratitis
)
5,133
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Pentostatin (2'-deoxycoformycin,
DCF
) was administered to 17 patients with a variety of lymphoid neoplasms, both T- and B-cell, that were refractory to conventional treatments. Several responses and 2 complete remissions occurred. Toxic effects were less severe than previously described: this may be attributable to relatively low doses of
DCF
or to precautions taken to prevent tumour lysis syndrome.
DCF
appears valuable as a second-line treatment in non-Hodgkin's lymphomas and as initial treatment in T-cell chronic lymphocytic leukaemia and mycosis fungoides. Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with
DCF
. The ocular toxicity of
DCF
, previously described as conjunctivitis, appears to be a
keratitis
of moderate severity which requires further study.
...
PMID:Effectiveness of pentostatin (2'-deoxycoformycin) in refractory lymphoid neoplasms. 660 39
