Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022568 (
keratitis
)
5,133
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Arabinosyladenine
(
Ara-A
) is an antiviral compound employed for ophthalmological lesions in the form of a 3 p. cent ointment. This purine nucleoside has been shown to possess antiviral activity against several ADN viruses, including herpes simplex virus, but it is ineffective against ARN viruses. Its action in superficial herpetic
keratitis
is comparable with that of idoxuridine, tolerance to the two compounds being almost identical.
Ara-A
is of value for treating superficial keratitis lesions not responding to idoxuridine. The weak intra-ocular penetration of
Ara-A
explains its lack of efficacy in stromal
keratitis
and herpetic kerato-uveitis, forms in which certain analogues of
Ara-A
could be beneficial.
...
PMID:[Arabinosyladenine in ophthalmology (author's transl)]. 702 53
The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (
Ara-A
), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and
Ara-A
in the treatment of experimental herpes simplex
keratitis
was investigated in rabbits. Treatment was initiated either at 4 or 24 h post virus inoculation. The parameter used to evaluate effectiveness was lesion size. Each eye was graded daily for the first 5 days and on alternate days thereafter to day 11. At concentrations of 2 or 5% both MMUdR and
Ara-A
were found to have potent antikeratitis activity. At 5% concentration,
Ara-A
provided essentially the same protection against herpes keratitis as 0.1% IUdR, while MMUdR was slightly less effective. The simultaneous application of 2% MMUdR and 2%
Ara-A
in combination was more effective than 5% MMUdR alone and was effective as 5%
Ara-A
or 0.1% IUdR in controlling the viral keratitis.
...
PMID:Comparative efficacy of 5-methoxymethyl-2'-deoxyuridine, 9 beta-D-arabinofuranosyladenine and 5-iodo-2'-deoxyuridine in the treatment of experimental herpes simplex keratitis. 735 40
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