Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The relationship between oral contraceptive (OC) use and eye disease was investigated through abstraction of salient data from the two large British cohort studies of the effects of OCs: the Royal College of General Practitioners' (RCGP) OC Study and the Oxford-Family Planning Association (FPA) Contraception Study. Together, these studies have accumulated over 850,000 person-years of observation since 1968 involving 63,000 women. The conditions considered in the analysis were conjunctivitis, keratitis, iritis, lacrimal disease, strabismus, cataract, glaucoma, retinal detachment, and retinal vascular lesions. The only eye disease for which there was consistent evidence of a notable increase in risk in OC users was retinal vascular lesions. The relative risk of retinal vascular lesions in OC users compared to never users was 2.0 (95% confidence interval (CI), 1.0-3.8) in the RCGP data set and 2.4 (95% CI, 0.4-9.2) in the Oxford-FPA Study. This increased risk was not concentrated in any one diagnostic category (e.g., retinal vascular occlusion, retinal vein thrombosis, retinal hemorrhage).
 ...
PMID:Oral contraception and eye disease: findings in two large cohort studies. 1091 85