Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a prospective study of the ocular manifestations of Kawasaki's disease (mucocutaneous lymph node syndrome) in 18 children (11 boys and seven girls, ranging in age from 5 months to 9 years), we found bilateral injection of the bulbar conjunctiva in 16, bilateral iridocyclitis in 14, superficial punctate keratitis in four, vitreous opacities in two, papilledema in two, and subconjunctival hemorrhage in one. Conjunctival injection and iridocyclitis were always bilateral, and fellow eyes always had the same degree of inflammation. There were significant correlations between ocular inflammation and erythrocyte sedimentation rate (P less than .0001) and C-reactive protein level (P less than .0009). No serious ocular complications occurred.
 ...
PMID:Ocular manifestations of Kawasaki's disease (mucocutaneous lymph node syndrome). 720 Dec 45

Hepatocyte derived C-reactive protein (CRP) is a sensitive indicator for inflammatory or infectious processes in a variety of tissues. As several other plasma proteins it is regarded as part of the acute phase response to a variety of tissue damage. CRP is commonly used in general medicine as a tool for the follow-up of especially bacterial infections. However, it has not been widely used in ophthalmology. In the present study CRP values in serum samples from 51 patients with various acute ocular diseases were determined semiquantitatively. High CRP levels were found most frequently in patients with either preseptal cellulitis (83.3%) or endophthalmitis (25.8%) whereas in the serum of patients with keratitis and uveitis, CRP exceeded 20 mg/l in only 18.7% of the cases. In a control group of 10 patients with retinal detachment the mean CRP level was 2.3 mg/l (SD +/- 0.98 mg/ml). The clinical significance and the prognostic value of CRP determinations during ocular diseases are discussed.
 ...
PMID:C-reactive protein serum levels in patients with ocular disease. 801 82

The purpose of the study was to develop a procedure for predicting a relapse of herpetic keratitis in children, by taking into account the results of tear biochemical analysis. The tears from 47 children with herpetic keratitis were examined for the levels of total protein, the concentration of acute-phase proteins, such as orosomucoid and C-reactive protein, the activities of transferases: gamma-glutamyltranspeptidase transferase, aspartate aminotransferase, and alanine aminotransferase, those of lysosomal glycosidases: alpha-mannosidase, beta-glycosidase, and beta-glucuronidase. Tear biochemical assay made it possible to evaluate the efficiency of treatment and to develop a procedure for predicting a recurrence of herpetic keratitis in children. Determination of the tear activity of the glycosidases may be used to predict recurrent herpetic keratitis in children.
 ...
PMID:[Use of tear enzyme assay to predict recurrent herpetic keratitis in children]. 1780 56