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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Varied manifestations of herpes simplex keratitis are postulated to be related to alterations or paucity of protective immune response to the virus. In this study lymphocyte subpopulations and macrophage inhibition factor (MIF) assay are investigated in herpes simplex keratitis. Active T-lymphocytes are detected to be significantly low in active keratitis as compared to the healed stage (P less than 0.001) and normal control subjects (P less than 0.01). Active T-cells are also lower in bilateral keratitis than in unilateral keratitis (P less than 0.01), and in stromal keratitis than in epithelial keratitis (P less than 0.05). Total E-rosette-forming cells and leucocyte migration inhibition factor (MIF) assay demonstrates significantly lower values in bilateral keratitis than in unilateral keratitis, and in stromal keratitis than in epithelial keratitis. On healing, total E-RFC, active T-cells and MIF values improved and are comparable to those found in normal subjects. Enumeration of absolute lymphocyte counts and EAC rosette-forming cells (B-lymphocyte cells) did not yield any differences. Our observations demonstrate paucity of cell-mediated immune response in stromal keratitis. More marked deficiency is demonstrable in bilateral keratitis. Manifestations of herpes simplex keratitis and their healing is observed to be relatable to the level of cell mediated immune response.
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PMID:Cell mediated immunity in herpes simplex keratitis in man. 227 44

Herpes simplex virus can affect the cornea in many ways, the main differences concerning the evolutive stage and the severity. Using the rosettes technique, we have tried to know if the study of the T lymphocytes subsets may give some help in foreseeing the risk of stromal or recurrent keratitis. Peripheral lymphocytes and T lymphocytes subsets: total E, E-active, autologous rosettes forming cells (E, E-act., auto-RFC) were studied among 60 patients with different clinical manifestations of herpetic keratitis: i.e. 27 epithelial and 23 stromal ones, 20 primary and 40 recurrent keratitis. Two groups of patients were found to have decreased levels of one T lymphocytes subset: the stromal ones with the most serious prognosis had above all a E-act--RFC decrease (16,5 +/- 8,5% vs 24,1 +/- 4,7 for the controls, p 0,001); the recurrent ones had above all a E-RFC decrease (53,6 +/- 6,4% vs 63,7 +/- 8,7 for the controls, p less than 0,001). So the most severe herpetic keratitis: recurrent and stromal ones seem to have cellular immunity abnormalities that are not found in the superficial or primary keratitis.
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PMID:[Ocular herpes. Correlations between subpopulations of T lymphocytes and clinical manifestations?]. 698 52