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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vital staining with an aqueous solution of 1% Congo red has been studied in the slit lamp. In 98 cases the dye was mixed with 1% lissamine green, in 120 eyes subsequent staining was performed with 0.125% fluorescein, and in 80 cases the mucous thread from the inferior conjunctival fornix was microscoped. Congo red stains dead cells, degenerate cells, and mucus. The dye discloses keratitis, corneal erosion, contact lens damages, corrosions, etc. It stains like lissamine green and rose bengal, though less frequently and less intensely than these. Congo red is a pH indicator. Acid reaction beyond its pH-range (3.0-5.2) has not been demonstrated. Amyloid-specific colour reaction (red-green dichromatic polarisation) has been noticed in mucous fibrils, most often in relation to infectious conjunctivitis and corrosion, never in normal eyes. The phenomenon is believed to indicate degeneration of the mucous fibrils (on the analogy of toluidine-blue-stained mucus), whereas not presence of genuine amyloid. It is, in other words, an important phenomenon in the differential diagnosis. Congo red is hardly indicated in ordinary clinical practice for vital staining of cornea and conjunctiva. Fluorescein, combined with rose bengal or lissamin green should be preferred.
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PMID:Congo red vital staining of cornea and conjunctiva. 6 86

A total of 209 pathological eyes each had 17 localities tested for sensitivity (cornea, caruncle, upper and lower lid margins (centrally, medially and laterally), and corresponding localities on the palpebral conjunctiva, and upper and lower halves of the bulbar conjunctiva). Reduced conjunctival sensitivity is seen in pemphigoid (excluding the lid margin) in contact lens wearers, at sites of nerves transected during operation and in rare cases of infectious conjunctivitis. Isolated corneal hypaesthesia is seen in bacterial or fungal keratitis. In herpes, the hypaesthesia extends over the bulbar conjunctiva, in zoster, over wider areas (including the lid margin). The sensitivity is normal in keratoconjunctivitis sicca and chronic conjunctivitis. In neurological diseases the hyposensitivity could include the cornea, conjunctiva and lid margin. The conclusion is drawn that a study of the conjunctivo-corneal sensitivity can give differential diagnostic information, provided the normal sensitivity range is known. This has been set out in a Table in 10-year age groups.
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PMID:Conjunctival sensitivity in pathological cases, with simultaneous measurement of corneal and lid margin sensitivity. 110 26

Application of sound ocular therapeutic principle is more difficult in food animals than most other species. Financial or husbandry constraints limit the practitioner's ability to use the entire range of ocular drugs available or to use them with adequate frequency. These problems may be dealt with by using systemically administered drugs when effective or by employing vehicles or delivery techniques that necessitate minimal dosing frequency. By far the most important medically treatable eye disease encountered in food animal practice is IBK. Effective therapies include systemic administration of long-acting oxytetracycline, subconjunctival administration of a variety of antibiotics, or topical application of benzathine cloxacillin. Infectious conjunctivitis in sheep and goats due to a variety of agents may be treated successfully with tetracycline in most cases. Conjunctivitis and keratitis secondary to IBR virus usually are given supportive therapy only, although specific antiviral drugs have been used in the treatment of herpetic eye disease in other species. Anterior uveitis is best treated by corticosteroid and mydriatic therapy in addition to treatment of the underlying cause, if identified.
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PMID:Ocular pharmacology. 176 Jul 61

Tears are absorbed by a tuft of cotton and subjected to stix test for leucocyte-esterase (L), nitrite (N), haemoglobin (H), and albumin (A). Testing of 84 cases of infectious conjunctivitis and 282 normals revealed nosographic sensitivity to L in 89% and a specificity of 98%. By including N (only 26% positive with infectious conjunctivitis) and H the sensitivity rose to 98% while the specificity fell to 95%. A was generally raised in cases of infectious conjunctivitis. An additional number of 607 stix tests were carried out on a clinical series. The reaction was controlled before, during, and after cataract extraction. Conjunctivitis patients were observed for possible infection, the result of antibiotic treatment was studied, and contact lens wearers were controlled for infection. Predominantly stix-positive reaction was noticed in keratitis, allergic conjunctivitis, and ocular prosthesis socket. Predominantly negative reaction was seen in chronic simple conjunctivitis, sicca, scleritis, and iritis, the latter despite pronounced ciliary hyperaemia. Contralateral reflexly induced L and H were rendered probable. H-positive reaction predominated immediately after removal of suture. The tear stix test is easy to carry out, reasonably precise, and valuable in the clinical work.
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PMID:Tear stix tests for leucocyte-esterase, nitrite, haemoglobin, and albumin in normals and in a clinical series. 265 63

The patient with a red eye constitutes a very common clinical problem encountered in the Emergency Department setting. Conjunctivitis, the most common cause of the red eye, generally is not associated with disturbance of vision or associated ocular pain. If either of these symptoms is present, a more serious disorder must be suspected. Treatment of infectious conjunctivitis is guided by interpretation of a Gram's stain and subsequent culture of any exudate present. Initial treatment of most cases includes use of topical antibiotic and local comfort measures. Complications of infectious conjunctivitis include more invasive disease such as keratitis or abscess formation, with potential corneal perforation and destruction. All patients should be referred for ophthalmologic followup, both to assess adequacy of treatment and to treat unexpected complications. Remember that allergic conjunctivitis is a common condition that responds to antihistamine decongestant medications given orally or topically. Occasionally these conditions are caused by self-prescribed use of ocular medication, and discontinuation of all eye medication is required. Corticosteroid eye drops are rarely indicated and should be used only at the direction of an ophthalmologist. When the diagnosis is uncertain, treatment is best withheld, as "shotgun" therapy is seldom beneficial.
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PMID:The red eye. 327 86

In Fall 1981, an outbreak of acute infectious conjunctivitis with keratitis (EKC) occurred in patients who had visited a private ophthalmology clinic just prior to onset of illness. Among an estimated 2,200 patient visits to the office from August 10 to October 15, 1981 for problems unrelated to infectious conjunctivitis, 39 (1.8%) persons subsequently developed EKC. The median incubation period was 6.5 days (range, 1 to 14 days). A case-control study was done to identify risk factors associated with contracting EKC; patients with EKC were more likely than control patients to have been examined by one or the other of two of the four ophthalmologists at the clinic and to have undergone procedures such as tonometry or foreign body removal. Adenovirus was isolated from conjunctival swabs from four of five persons with conjunctivitis; three were type 8 and one was type 7. Recognition of the problem and improved handwashing practices were associated with terminating the outbreak. This outbreak illustrates the potential for transmission of adenovirus infection during the provision of eye care. Infection control practitioners should be familiar with measures for the prevention of such infections among ophthalmology patients.
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PMID:Epidemic keratoconjunctivitis: report of an outbreak in an ophthalmology practice and recommendations for prevention. 609 Mar 33

The modern local antibiotics, such as the aminoglycosides and quinolones, are very successful in treating infectious conjunctivitis and keratitis. More notably in some Third World countries, however, suppurative keratitis is found in more than half of the infectious disease cases caused by Fusarium species. Here, of course, treatment should be antifungal. The emergence of some problematic microorganisms is related to contact lens wear. Pseudomonas, for example, have the ability to adhere to contact lenses and thus form microcolonies, which are protected by biofilm that predisposes to infection. Acanthamoeba infections of the cornea are a direct consequence of inappropriate or inadequate disinfection of contact lens systems. Occasionally the diagnosis of herpes simplex manifestations of the outer eye can be very difficult. Even more confusing is the delayed appearance of zoster manifestations, such as pseudodendrites, particularly in cases of zoster sine herpete eruptione. The polymerase chain reaction is of particular value in demonstrating the presence of varicella zoster DNA. Although infectious disease of the outer eye remains common, the incidence and complications have increased because of frequent use of antimicrobial agents. In the under-developed areas of the world, however, infections are still very common, are frequently caused by fungi, and are the cause of serious ocular complications. In the Western World infectious eye disease does not seem to be a major diagnostic or therapeutic point at present. Some organisms that have been in the environment all along, however, have emerged in the past half century as a major problem. Thus, in the past years a number of new techniques in diagnosis as well as new insights in pathophysiology and new developments in treatment have emerged that are of interest.
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PMID:Infectious diseases of the conjunctiva and cornea. 1016 42

Recent advances in the field of infectious conjunctivitis and keratitis include new diagnostic methods, the identification of new pathogens, and novel therapeutic agents. Tandem confocal microscopy has been used to diagnose Acanthamoeba keratitis, and polymerase chain reaction has proven to be a rapid and sensitive technique for detecting specific viral antigens, particularly in cases where cultures yield no growth. Two new antiviral agents, ganciclovir and carbocyclic oxetanocin G, have been shown to be as effective as acyclovir in treating herpetic epithelial disease. The fluoroquinolones, especially ofloxacin, have become the antimicrobial agents of choice in the initial management of selected cases of bacterial keratitis.
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PMID:Corneal and conjunctival infections. 1017 Apr 40

Ophthalmic allergoses belong to highly prevalent ocular diseases. According to the records of the first center of allergic diseases of the eye set up in 1971 at Helmholtz Institute of Ocular Diseases in Moscow, the most prevalent clinical forms are seasonal pollenosis conjunctivitis, drug allergies, spring keratoconjunctivitis, large-papillary conjunctivitis, chronic allergic conjunctivitis, allergy associated with the "dry eye" syndrome, atopic keratoconjunctivitis, and ocular involvement in systemic immune diseases. Therapy of ocular allergies is based on the three main principles: removal of the allergen responsible for disease, immunotherapy, and symptomatic drug therapy. The main agents used in local antiallergic therapy are antihistaminic drugs (antasoline and acelastin), drugs inhibiting mast cell degranulation (chromoglycates and lodoxamide), and accessory drugs: corticosteroids (dexamethasone and deosonide), nonsteroid antiinflammatory agents (diclofenak), immunosuppressants (cyclosporin), and vasoconstrictors (tetrisoline). Antiallergic drugs can be used as monotherapy or in combinations, as they differ by the mechanism of action. Antiallergic drugs are used with good results in combined therapy of infectious conjunctivitis and keratitis.
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PMID:[New aspects in drug therapy of ocular allergies]. 1122 68

Diabetes Mellitus (DM) is a serious medical problem that causes long-term systemic complications and considerable associated morbidity. DM can cause retinopathy (DRP), maculopathy, cataract, optic neuropathy, defects of eye muscles. DM is a risk factor for acute infectious conjunctivitis, bacterial keratitis, herpes virus infections and endophtalmitis. Elevated blood glucose induces structural, physiological and hormonal changes which affect retinal capillaries. DRP is recognized by loss of pericyte function and capillary occlusions together leading to breakdown of blood-retinal barrier, edematous changes and proliferation of vessels and fibrous tissue. Depending on stage of DRP, there are different preferable therapeutic approaches applied. In the case of ETDRS, in the area of leakage focal treatment should be performed, while panretinal photocoagulation is applied towards ischemic areas or beginning proliferations. Vitreal haemorrhage followed by fibroproliferative changes or tractional retinal detachment is treated by vitrectomy alone or in combination with ILM peeling. In pathogenesis of DRP, Insulin Growth Factor (IGF-1) can play an important role in production of VEGF (Vascular Endothelial Growth Factor). Hypoxia can up-regulate VEGF expression levels leading to pathologic ocular neovascularisation. An application of intravitreal corticosteroid treatment modulates vascular permeability by suppressing the production of VEGF, reducing both extracellular matrix metalloproteinase activity and basic fibroblast growth factor, decreasing major histocompatibility complex 2 Ag expression levels, and inhibiting activity of inflammatory cells. Clinical effects of treatment using intravitreal corticosteroids are evaluated by reduction of macular thickness and visual improvement. Intravitreal use of Anti-VEGF drugs, Pegaptanib, Ranibizumab and Bevacizumab can modify vasoproliferation, trigger macular edema, and, therefore, influence a prognosis for visual loss.
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PMID:Eye disorders in diabetes: potential drug targets. 1853 2


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