Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experimental fungal keratitis was established in the pigmented rabbit by intralamellar injection of Aspergillus fumigutus suspension after superficial corneal trephination. Examination of clinical manifestations was combined with light microscopy, SEM, TEM, and slit-lamp microscopy in the study of pathological and symptomatic development. The morbidity occurred in all the 45 eyes inoculated, as corneal ulcer (100%), immunity ring (72%), hypopyon (64%), and radial turbidity of hyphae growth (28%); satellite lesions were not found. The pathogenesis of keratomycosis possibly included direct damage by fungal extension, infiltration of polymorphonuclear leucocytes, and action of fungal toxins. The pathological basis for the clinical manifestations of keratomycosis was also discussed.
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PMID:[Light and electron microscopic observations of experimental keratomycosis]. 268 77

We tested the antibacterial activity of ophthalmic 0.3% ciprofloxacin against that of 5.0% cefazolin and 1.36% tobramycin in two experimental models of keratitis, using a methicillin-sensitive strain of Staphylococcus aureus and an aminoglycoside-sensitive strain of Pseudomonas aeruginosa, respectively. Both corneas of New Zealand white rabbits were intrastromally injected with either S. aureus or P. aeruginosa. Twenty-four hours later, each eye was topically treated hourly for 24 hours. In the S. aureus model, the control group received Tears Naturale Free (Alcon Laboratories, Inc., Fort Worth, TX), the ciprofloxacin group received 0.3%, ciprofloxacin and the cefazolin group received 5.0% cefazolin. In the P. aeruginosa model, the control group received Tears Naturale Free, the ciprofloxacin group received 0.3% ciprofloxacin, and the tobramycin group received 1.36% tobramycin. One hour after the last eyedrops were administered, the rabbits were killed, and their corneas were processed for quantification of bacteria. For the S. aureus model, the mean (+/- SEM) colony forming units (CFU) of the control, 7.1 x 10(6) (+/- 4.0 x 10(6)); ciprofloxacin, 6.4 x 10(2) (+/- 1.6 x 10(2)); and cefazolin, 1.3 x 10(3) (+/- 1.8 x 10(2)) groups were different (F = 17.5; p = 0.001). The ciprofloxacin and cefazolin groups were not different from each other (p = 0.034). The mean (+/- SEM) CFU for the control group in the P. aeruginosa model was 2.8 x 10(8) (+/- 1.7 x 10(7)). All corneas in the ciprofloxacin and tobramycin groups were sterile.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Topical ciprofloxacin versus topical fortified antibiotics in rabbit models of Staphylococcus and Pseudomonas keratitis. 826 84