Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

35 cases of secondary glaucoma due to congenital syphilitic interstitial keratitis have been surveyed. In four cases which had no opacities in the cornea, but with positive serologic reaction for syphilis, the characteristic goniscopical features such as peripheral anterior synechia, pigment deposits in the trabeculum, and irregularity of iris configuration as observed commonly in cases with inactive congenital interstitial syphilitic keratitis, were found. In the clinical course and goniscopical findings, they were divided into two types: one was the angle closure type with acute glaucomatous attack, and the other the wide open angle type with insidious course of the disease. The prognosis of this secondary glaucoma was very poor, although medical therapy was taken for the wide open angle type, and surgical therapy for the angle closure type. In the present study, the importance of gonioscopical examination, and careful attention to avoid the ufention to avoid the further formation of peripheral anterior synechia in the surgical procedure, was stressed for secondary glaucoma with congenital interstitial syphilitic keratitis.
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PMID:Secondary glaucoma due to inactive congenital syphilitic interstitial keratitis. (With 1 colour plate). 87 Aug 61

A high incidence of keratoconjunctivitis was observed in a closed colony of inbred Lewis/Wistar rats. Clinical signs including blinking, ocular discharge, circumcorneal flush, corneal opacity, ulceration, pannus, hypopyon, and hyphema were observed at about three weeks of age. Acute disease subsided by six weeks of age, but some lesions progressed to low-grade chronic keratitis. Six per cent of affected rats developed megaloglobus, which usually appeared by three weeks of age. Lesions included focal or diffuse interstitial keratitis, corneal ulceration, anterior synechia, and inflammatory exudate in the anterior chamber. A high incidence of lenticular and retinal degeneration was associated with megaloglobus. Most affected rats also had harderian dacryoadenitis. Sialodacryoadenitis virus (SDA) was recovered from nasal washes, but not from affected eyes. Serological evidence indicated that SDA virus infection was widespread in the colony.
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PMID:Keratoconjunctivitis associated with sialodacryoadenitis in rats. 93

The corneal buttons after corneal graft of 22 patients with herpetic keratitis were studied (16 male, 6 female; 7-87 years of age). Ten still had active inflammation, while 12 had stabilized by the time of the study. Different degrees of neovascularization were observed in 19 cases. HLA-DR antigen was detected in the corneal epithelium in 7 of 22 cases (32%), in the corneal stroma in 17 of 22 cases (77%), and in the endothelium in 9 cases (41%) by using the immunohistochemical technique. The expression of HLA-DR antigen was more common and more marked in active herpetic keratitis (90%) and in neovascularized corneas (84%). The frequency and density of HLA-DR expression in perforating corneal ulcers were no higher than in other cases, but anterior synechia was accompanied by strong expression of HLA-DR antigen in the corneas. The expression of HLA-DR antigen was not only detected in the peripheral, but also in the central area of the specimens. The cells expressing HLA-DR antigen in corneas were mainly corneal cells. The results showed a close relationship between HSV-keratitis and the expression of HLA-DR antigen, which may be induced during the clinical course of the disease. The expression of HLA-DR might be one of the factors in the recurrent onset of the disease and a significant sign of the prognosis of corneal transplantation for these patients.
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PMID:Clinical and immunohistochemical correlation of herpetic keratitis with the expression of HLA-DR antigen. 846 89