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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three cases of congenital euryblepharon are presented. In these cases, horizontal width of the eyelid margin is abnormally increased in comparison to the globe and orbit. The 3 cases were all different. One case had involvement of all 4 lids. Another had unilateral involvement of upper and lower eyelids. A third case had bilateral lower lid involvement associated with other anomalies. The additional anomalies which have not been previously reported include a double row of meibomian gland orifices and an extreme lateral displacement of the lower canaliculus and punctum. All cases had varying degrees of vertical shortage of skin in the involved lids leading to lagophthalmos with a mild to moderate exposure keratitis. A review of previously reported cases of euryblepharon is made. The types of surgical procedures used to correct the deformities are discussed.
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PMID:Congenital euryblepharon. 55 49

A congenital teratoma of the orbit is described. Histologically, the tissues forming the tumor appeared derived from the three germinal layers and showed an advanced degree of differentiation. An exenteration was performed because of suspicion of malignant tumor in the orbit and because of the severe keratitis with impending perforation which ensued the lagophthalmos.
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PMID:Congenital teratoma of the orbit. 89 44

Different manifestations on some ocular and adnexal structures may accompany ichthyosis. Some ophthalmological manifestations in the clinical course of ichthyosis may endanger the eye and even lead to the sight loss. The paper reports a case of a patient with congenital ichthyosiform erythrodermia and ophthalmological manifestations on the lids and cornea. In addition to ichthyosis of the lid skin, squamous blepharitis and cicatricial ectropium of the lower lids were also present, while signs of exposure keratitis on the right eye and corneal leucostaphyloma on the left eye were also noted. Presence of lagophthalmos and permanent exposure of both eyeballs led to deterioration of the condition which may result in the sight loss on the right eye, as well. Therefore, contracture release of both lower lids was performed followed by full-thickness skin graft. Surgical procedure and the postoperative course were uneventful. The operation successfully corrected position of the lower lids and enabled formation and reestablishment of the precorneal tears film which led to improvement of the condition of the cornea. The effect has been maintained for six postoperative years now.
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PMID:[Ophthalmologic manifestations in patients with ichthyosis]. 130 16

Forty-eight leprosy patients in The Netherlands were re-examined 10 years after initial examination. Forty-six of these patients had received a course of multidrug therapy (MDT), according to the World Health Organization recommendation, at the time of their initial examination. Two patients had burned-out disease and had been merely under observation. Out of 40 patients, who initially did not show eye complications due to leprosy, 37 patients were essentially the same 10 years later. The eyes had changed in 3 multibacillary patients: 1 patient had developed a late type 1 reaction with facial nerve involvement and lagophthalmos; 2 patients had undergone intra-ocular surgery for cataract and acute glaucoma, respectively. Out of 8 patients with pre-existing eye involvement, 1 patient recovered and the lesions in 2 patients remained unaltered. One patient showed progression of pre-existing exposure keratitis. Four patients had undergone cataract extractions; all four patients were lepromatous, with a long history of disease and signs of iris involvement at the first examination. The main progressive lesions were cataracts in lepromatous patients.
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PMID:Progression of eye lesions in leprosy: ten-year follow-up study in The Netherlands. 189 Mar 62

A case of facial palsy with lagophthalmos with exposure keratitis was corrected surgically by a method of temporalis transfer. When the slings were tightened leaving 1 cm gap in the palpebral aperture, lagophthalmos persisted. A secondary tightening procedure causing overlap of the upper lid over the lower yielded good results.
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PMID:Management of a case of lagophthalmos by Gillies' method (a case report). 209 67

Facial paralysis can result in serious keratopathy because of corneal exposure and inadequate lacrimation. Thirty-seven patients underwent thirty-eight gold weight upper lid implants to rehabilitate paralysis of the eyelid from various causes. When indicated, implantation was combined with lower lid ectropion repair, medial canthoplasty or brow lift. Because of encouraging results in patients with longstanding facial paralysis, "early" implantation (within 1 month of paralysis) was offered to patients with severe lagophthalmos in whom (1) a severe neural injury was documented at the time of transtemporal surgery or (2) delayed, incomplete return of function was expected. Gold weight implantation resulted in excellent eyelid closure, protection, and cosmesis. There were no infections or extrusions. Lagophthalmos and exposure keratitis resolved or were significantly improved in all patients, and most were able to dispense with eyedrops and salves. Visual acuity improved in 95% of patients--a benefit even those without preoperative keratitis often achieved. A mild worsening of one patient's pre-existing astigmatism developed, which resolved after reimplantation with a lighter weight. The implant is easily removed from those patients who, having undergone early implantation, eventually recover adequate function. Gold weight loading has become our procedure of choice for eyelid rehabilitation.
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PMID:Early gold weight eyelid implantation for facial paralysis. 212 16

The present paper reports on the curative effect of the 0.1% Sodium hyaluronate (Na-HA) eyedrops jointly manufactured by Guangzhou Red Cross Hospital and Guangzhou Institute of Medical & Pharmaceutical Industry. 70 cases were studied. There were kerato-conjunctivitis sicca, lagophthalmos corneal fluorescein diffuse punctate epithelial lesion caused by contact lens, and keratitis punctata superficialis. The results showed effective treatment which occupied 95.7%. In the discussion, the authors point out that Na-HA has the same stagnatisity and elasticity as biotears because of its adhesion to the corneal epithelium. Moreover, it has the water-retaining microsponge action similar to that of mucopolysaccharide. Hence, Na-HA has protective effects on corneal epithelium. Finally, the authors conclude that Na-HA eyedrop is so far the most ideal substitute for tears and superior to other artificial tears.
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PMID:[The clinical use of sodium hyaluronate eyedrops as a substitute for tears]. 228 73

Patients with chronic progressive external ophthalmoplegia (CPEO) are often disabled by ptosis; however, conventional ptosis surgery may induce lagophthalmos and exposure keratitis. Ten patients with CPEO underwent ptosis correction via bilateral frontalis suspensions, using monofilament synthetic material. Three of these patients were also treated with lower eyelid horizontal tightening. The frontalis sling was adjusted to provide a firm linkage between the eyebrow and eyelid, but was loose enough to allow eyelid closure when the frontalis muscle is relaxed. All patients experienced lessening of ptosis and relief from visual obstruction. One patient required reoperation of one eyelid for undercorrection. No lagophthalmos or corneal complications occurred. The rationale for treatment, preoperative evaluation, and operative procedure in CPEO is discussed herein.
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PMID:Management of ptosis in chronic progressive external ophthalmoplegia. 315 93

We report on a male patient with exophthalmos of unclear etiology, basilar impression, syringohydromyelia and type II Arnold-Chiari malformation. Two diseases involving the orbital region were to be considered in differential diagnostic terms: endocrine orbitopathy and osseous orbit dysplasia. The typical physical appearance associated with basilar impression as well as suppurative keratitis in Lagophthalmos was striking. Tetraspasticity with pareses, bulbar symptoms, proximally pronounced muscular atrophy as well as a left hemihypesthesia was shown neurologically. Although the orbit CT was normal, sonography revealed thickened ocular muscles. There was euthyroidism in diffuse goiter with negative thyroid autoantibody findings. Because of lack of definitive detection of muscular swelling, tumor, or vascular anomaly in the various images, orbital dysplasia in the context of a malformation syndrome affecting several organs is suggested as the cause of the exophthalmos.
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PMID:Exophthalmos and basilar impression. A contribution to differential diagnosis of endocrine orbitopathy. 325 Nov 72

A clinical examination of 199 leprosy patients in Kenya showed that 62.5% had abnormal ocular findings, 51.2% of which were leprosy related. The potentially blinding lesions were uveitis, keratitis and lagophthalmos and these were found in 22.1% of the patients. 6 Patients (3%) had a visual acuity of less than 3/60 in the better eye and were classified blind. In all, there were 31 blind eyes of which only 12 had leprosy related causes. 10 of these (83%) belonged to lepromatous patients and 2 (17%) to tuberculoid patients. All the 10 eyes of the lepromatous patients were blind due to uveitis. It was shown that lepromatous leprosy patients are at a greater risk of leprosy related blindness especially from uveitis. The socio-psychological and economic implications of leprosy are discussed. Practical recommendations for the primary eye care of the leprosy patient are suggested.
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PMID:Ocular leprosy in Africa. 664 92


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