Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chronic mucocutaneous candidiasis is a rare skin condition that may be associated with immunologic defects, failure of the endocrine system, or a neoplasm, especially thymoma. Ocular findings are rare. Our patients, a middle-aged man, had chronic mucocutaneous candidiasis in conjunction with an aggressive malignant thymoma. He was initially seen with recurrent Candida keratitis and subsequently had Candida esophagitis and a polymicrobial lung abscess. The skin, nail, mucous membrane, and conjunctival involvement responded to oral ketoconazole therapy. This syndrome consists of at least five groups, and various pathogenetic mechanisms and therapeutic agents have been proposed.
 ...
PMID:Chronic mucocutaneous candidiasis and keratitis associated with malignant thymoma. 683 96

Hypogammaglobulinemia develops in 3 to 6% of patients with thymoma and this association is commonly referred to as thymoma with immunodeficiency (formerly Good syndrome). Recurrent infections with encapsulated bacteria and opportunistic infections associated with disorders of both humoral and cell mediated immunity frequently occur in this rare primary, adult-onset immunodeficiency. We report a case of thymoma with immunodeficiency complicated by disseminated herpes simplex virus (HSV) infection and review five additional cases of HSV-related infections reported since 1966 in patients presenting with thymoma with immunodeficiency. Patients presented with epiglottitis, keratitis, recurrent genital herpes, ulcerative dermatitis, and acute hepatitis. Four of the six cases had a fatal outcome, two of which were directly attributable to HSV infection. Since the risk of invasive opportunistic infections is high and the presentation atypical, lymphocyte count and total serum immunoglobulin should be measured regularly in all patients presenting with thymoma with immunodeficiency.
 ...
PMID:Thymoma, immunodeficiency, and herpes simplex virus infections. 1926 57