Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical signs of impaired vision or neurological disease occurred in seven of 74 free-living moose (Alces alces) from Saskatchewan, Canada, submitted for necropsy between 1969 and 1994. Several lesions were found in each eye, including retinal degeneration (seven cases), cataract (six cases), lymphocytic-plasmacytic anterior uveitis (six cases), corneal scars (six cases), keratitis (four cases), and microphthalmia (one case), but their cause was not determined. Moraxella bovis was isolated from the cornea of one moose. Lesions in the brain and spinal cord were mild or absent.
 ...
PMID:Pathology of ocular lesions in free-living moose (Alces alces) from Saskatchewan. 902 95

The infection of humans with the rodent-borne lymphocytic choriomeningitis virus (LCMV) can lead to central nervous system disease in adults or severe neurological disease with hydrocephalus and chorioretinitis in children infected congenitally. Although LCMV-induced meningitis and encephalitis have been studied extensively, the immunopathological mechanisms underlying LCMV infection-associated ocular disease remain elusive. We report here that the intraocular administration of the neurotropic LCMV strain Armstrong (Arm) elicited pronounced chorioretinitis and keratitis and that infection with the more viscerotropic strains WE and Docile precipitated less severe immunopathological ocular disease. Time course analyses revealed that LCMV Arm infection of the uvea and neuroretina led to monophasic chorioretinitis which peaked between days 7 and 12 after infection. Analyses of T-cell-deficient mouse strains showed that LCMV-mediated ocular disease was strictly dependent on the presence of virus-specific CD8(+) T cells and that the contribution of CD4(+) T cells was negligible. Whereas the topical application of immunosuppressive agents did not prevent the development of chorioretinitis, passive immunization with hyperimmune sera partially prevented retinal and corneal damage. Likewise, mice displaying preexisting LCMV-specific T-cell responses were protected against LCMV-induced ocular disease. Thus, antibody- and/or T-cell-based vaccination protocols could be employed as preventive strategies against LCMV-mediated chorioretinitis.
 ...
PMID:Immunopathological basis of lymphocytic choriomeningitis virus-induced chorioretinitis and keratitis. 1894 66