Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ocular complications occur in about 50% of cases of ophthalmic zoster. They include inflammatory reactions of the eyelid, conjunctivitis, scleritis, keratitis, iridocyclitis, secondary glaucoma, optic neuritis, internal ophthalmoplegia, ocular motor palsies and exophthalmos. Very dangerous complications are a concomitant facial paralysis and a neuroparalytic keratitis. Then a tarsorrhaphy should be done in time. An ophthalmologist should be consulted, when the side of the tip of the nose presents vesicles (Hutchinson's rule).
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PMID:[Ocular complications in ophthalmic zoster (author's transl)]. 107 72

Markedly reduced vision and a shallow anterior chamber suggest acute glaucoma. A mucopurulent discharge suggests conjunctivitis. An abnormal cornea may suggest acute glaucoma or keratitis. An abnormal pupil is seen with both acute glaucoma and iritis.
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PMID:Overview of the red eye. 146 34

Intraocular melanoma was diagnosed in a 13-year-old horse. Secondary clinical findings included keratitis, cataract, and glaucoma. The eye was enucleated. Follow-up information did not give an indication of metastatic disease.
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PMID:Anterior uveal melanoma, with secondary keratitis, cataract, and glaucoma, in a horse. 174 9

Between 1979 and 1988, 85 penetrating keratoplasty procedures were performed in 54 patients aged 1 month to 18.2 years at the Hospital for Sick Children, Toronto. The minimum length of follow-up was 3 months. A clear transplant was obtained in 27 eyes: 7 of 16 eyes with Peter's anomaly, 0 of 8 eyes with congenital glaucoma, 2 of 5 eyes with herpes simplex keratitis, 6 of 8 eyes with corneal dystrophy and 12 of 17 eyes with traumatic corneal scars. The most recent visual acuity was best in the trauma and dystrophy groups and worst in the congenital glaucoma group. Visual acuity results were better in older children and were fair in younger children and those with postoperative complications. Although penetrating keratoplasty is more difficult in children than in adults, it has a reasonable chance of success. However, the poor outcome in the congenital glaucoma group indicates that the procedure is not warranted in such patients.
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PMID:Corneal transplantation in infants, children and young adults: experience of the Toronto Hospital for Sick Children, 1979-88. 188 22

Forty-eight leprosy patients in The Netherlands were re-examined 10 years after initial examination. Forty-six of these patients had received a course of multidrug therapy (MDT), according to the World Health Organization recommendation, at the time of their initial examination. Two patients had burned-out disease and had been merely under observation. Out of 40 patients, who initially did not show eye complications due to leprosy, 37 patients were essentially the same 10 years later. The eyes had changed in 3 multibacillary patients: 1 patient had developed a late type 1 reaction with facial nerve involvement and lagophthalmos; 2 patients had undergone intra-ocular surgery for cataract and acute glaucoma, respectively. Out of 8 patients with pre-existing eye involvement, 1 patient recovered and the lesions in 2 patients remained unaltered. One patient showed progression of pre-existing exposure keratitis. Four patients had undergone cataract extractions; all four patients were lepromatous, with a long history of disease and signs of iris involvement at the first examination. The main progressive lesions were cataracts in lepromatous patients.
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PMID:Progression of eye lesions in leprosy: ten-year follow-up study in The Netherlands. 189 Mar 62

Although both topical and systemic anti-inflammatory agents have a place in veterinary ophthalmology, they play only a small role in overall patient management. They must be used appropriately to prevent ocular damage and loss of vision from inflammation and are not a replacement for a complete ophthalmic examination and specific treatment directed at the etiology of the problem. If used indiscriminately, they can result in local or systemic side effects or toxicities, many of which are worse than the initial problem for which they were selected. Just as topical corticosteroids are contraindicated with infectious keratitis, so are systemic corticosteroids contraindicated in patients with ocular inflammation resulting from a systemic infectious process. Anti-inflammatories must be used at the appropriate dosage and frequency. Use of corticosteroids that have low intraocular penetration for intraocular disease or corticosteroids with low potency is a waste of time and money. The most expensive medication is one that does not work. Avoid combination therapies when only a single medication is required. These do not save time or money and have the potential to result in the development of drug-related diseases. Diseases for which anti-inflammatory therapy has little or no indication include corneal scars, corneal edema, corneal pigmentation, corneal dystrophy, cataracts without inflammation, glaucoma, and retinal atrophy and degeneration. Last, remember that all commercially available ophthalmic medications are specifically formulated for use in the eye. Their pH, concentration, osmolality, and melting temperature all are designed to facilitate penetration. The use of dermal and otic preparations to treat ophthalmic problems is contraindicated.
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PMID:Control of ocular inflammation. 219 54

There is a new trend in the US government's perception regarding health care today. It involves an increased awareness of how disease can be prevented and health promoted. The US government is supporting this concept with its Healthy People 2000 project. Specific pediatric concerns about health promotion and disease prevention in ophthalmology include amblyopia and strabismus, ophthalmia neonatorum, ocular trauma, radiation injury, xerophthalmia, herpes simplex, herpes zoster, infections and metabolic and genetic disorders. Adult health promotion/disease prevention priorities include glaucoma; trauma; diabetic retinopathy; corneal problems; iatrogenic infections; exposure keratitis; ocular toxicity from drugs, chemicals, and the environment; visual loss from neglect; and those mentioned in the pediatric area.
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PMID:Health promotion and disease prevention in ophthalmology. 221 91

Clinical picture and course of eye involvement were studied in 254 patients with Reiter's disease. Altogether 130 patients suffered from conjunctivitis of varying severity, 23 from keratitis, 21 from episcleritis, 20 from uveitis, 2 from detachment of the retina, and 5 from secondary glaucoma. Chlamydia were detected in one third of conjunctivitis patients in scrapings off the conjunctiva. The eyes may be accidentally infected by agents from the urogenital organs if the patient does not observe the hygienic rules. Uveitis developed as a rule after a prolonged course of Reiter's disease. They were resistant to antichlamydial therapy because of autoimmune factors that underlay the condition pathogenesis. Deposits of immune complexes on antigens of ocular vascular coating were detected with the use of monospecific antiglobulin sera in 7 of 10 patients with active uveitis symptoms. The risk of Reiter's disease development in HLA B27 carriers is 27.17 times higher than the mean incidence of this disease in the population. HLA A9 and B40 antigen combinations occurred 7 times more often in uveitis patients than in reference subjects, A1 and B27 combinations were 4-5 times more incident.
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PMID:[Ophthalmological aspects of Reiter's disease]. 223 33

Corticosteroids are widely used in the treatment of inflammatory and immunological diseases of the eye. They are given by three routes: topical application, periocular injection and systemic administration. Topical application, periocular injection and systemic administration. Topical application is used for anterior inflammatory diseases, such as conjunctivitis, keratitis or anterior uveitis. Posterior uveitis is treated with systemic and local injections. Herpetic keratitis is a contra-indications to the use of corticosteroids. Ocular side-effects are observed with systemic administration as well as with topical applications and local injections. They include posterior subcapsular cataract, rise of intraocular pressure and even glaucoma, failure in healing of corneal wounds and exacerbation of ocular infections. These side-effects are not always reversible when treatment is stopped. Prevention consists of repeated eye examination.
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PMID:[Corticosteroids and ophthalmology]. 232 Aug 79

Lymphoma was diagnosed in a 7-year-old domestic cat found to be infected with FeLV and feline immunodeficiency virus (FIV). The cat was affected by chronic disorders suggestive of immunosuppression, including gingivitis, periodontitis, keratitis, and abscesses. Despite treatment, peripheral keratitis of the left eye progressed, resulting in uveitis, chronic glaucoma, and eventual corneal rupture. Microscopic retinal and optic disk pathologic processes also were suspected. Abnormal jaw movements that were believed to be indicative of neurologic disease were observed. Approximately 17 months later, the cat developed generalized lymphadenopathy, hepatosplenomegaly, and bilateral renomegaly. Lymphoblastic lymphoma and glomerulonephritis were diagnosed histologically. Manganese- and magnesium-dependent reverse transcriptase activity were detected in supernatants from lymph node and spleen mononuclear cell cultures, suggesting T-lymphocyte infection with FeLV and FIV.
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PMID:Feline leukemia virus and feline immunodeficiency virus infections in a cat with lymphoma. 253 74


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