Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Upper and lower eyelid full-thickness reconstruction in a patient without available adjacent tissue because of burns or trauma is a surgical challenge. Our patient had severe thermal burns with complete unilateral defects in both the upper and lower eyelids. Although the skin grafts survived, contraction occurred quickly, subsequent ectropion of both the upper and lower eyelids, which could have lead to exposure keratitis and blurred vision. A retrograde postauricular island flap was harvested to provide skin eyelid coverage, and the donor site was directly closed. After another 2 surgeries, normal skin thickness and a color-matched appearance were achieved, and the donor-site scar was almost invisible from the anterior view. To our knowledge, it is rare to use a retrograde postauricular island flap in a full-thickness reconstruction of both the upper and lower eyelids, but the authors have ascertained that this method may be a reliable option in such selected and challenging situations.
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PMID:Upper and Lower Eyelid Full Thickness Reconstruction Using a Retrograde Postauricular Island Flap. 2635 61

The surgical management of severe ocular burns is challenging and often associated with variable long-term outcome. The aims of this study were to analyze the clinical course of these injuries and determine the factors associated with the need for surgery. A retrospective medical records review was conducted for patients admitted to the Victorian Adult Burns Services, with ocular burns, from January 2000 to January 2010. One hundred and twenty-nine patients were admitted with ocular burns, of which 17 (13.2%) required surgery. The most common indication for surgery was ectropion (n = 9) and the most frequent procedure was full-thickness skin grafts to the eyelids (n = 10). Almost all patients managed surgically developed late ocular complications, the most frequent being visual loss and recurrent ectropion (n = 7 each). Patients undergoing surgery had a longer length of hospital stay (median [interquartile range] 40 [12-90] vs 12 [4-29.5] days; P = .004) and larger TBSA burned (median [interquartile range] 20 [10-60] vs 8 [4-20]; P = .011). Factors associated with the need for surgery included flame burns, periorbital edema, visual loss on presentation, increasing severity of eyelid and facial burns, severe corneal injury, as well as lagophthalmos, ectropion, and microbial keratitis (P < .05). Although only a minority required surgery, these patients often require multiple procedures and develop long-term ocular morbidity.
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PMID:Risk Factors for Ocular Burn Injuries Requiring Surgery. 2735 55

One hundred and eighteen cases of leprosy with ocular involvement were found to have corneal involvement out of a total 274 cases of ocular in volvement in leprosy. The common eye lesions observed were chronic conjunctivitis (54.01%), keratitis (47.07%), iritis (31.75%) and lagophthalmos (27.76%). In 38.98% of the cases, the time lag between the onset of skin lesions and corneal lesions was 5 to 15 years. The major causes, which lead to involvement of cornea, were corneal anaesthesia (116), lagophthalmos (76), ectropion (21), entropion (11) and trichiasis (4). Corneal blindness constituted 55.6% of total blindness in leprosy with ocular involvement.
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PMID:Corneal Blindness in Leprosy in Eastern Uttar Pradesh. 2816 50

A case of discoid lupus erythematosus (DLE) in a 20 year old female patient is presented. The, case clinically resembled lupus causing bilateral ectropion and exposure keratitis in both eyes.
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PMID:Discoid Lupus Erythematosus Resembling Lupus Vulgaris. 2819 31

Autosomal recessive congenital ichthyosis (ARCI4B [OMIM #242500]), also known as harlequin ichthyosis, presents at birth with extreme hyperkeratosis and thick-fissured plaques, leading to tightness of the skin around the eyes, mouth, ears, chest, abdomen, and extremities. Ocular manifestations include cicatricial ectropion and exposure keratitis. We present 2 infants with ARCI4B and cicatricial ectropion who were managed with aggressive nonsurgical therapy. Both infants avoided severe ocular sequelae and maintained corneal clarity, highlighting that management of exposure keratopathy with frequent ophthalmic ointment application can prevent severe ocular surface pathology in ARCI4B.
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PMID:Management of ocular manifestations of autosomal recessive congenital ichthyosis 4B, harlequin type, in the perinatal period. 3158 85

A 3-year-old Thoroughbred filly presented to a referral equine hospital for surgical correction of a severe cicatricial lateral lower eyelid ectropion OD, with secondary exposure keratitis. The severity of the ectropion deemed that conventional ectropion repairs would be unsuccessful. Therefore, a soft tissue expansion device was used to create sufficient local tissue for a rotational graft with tension-relieving horizontal incisions to be performed to facilitate closure and acceptable eyelid apposition. The keratitis had resolved by two months postoperatively. There were no long-term complications and only mild recurrence of the keratitis observed 14-years postoperatively.
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PMID:Use of a chronic soft tissue expansion device to facilitate blepharoplasty in a horse with lower-lid cicatricial ectropion with a 14-year follow-up. 3268 27


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