Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022568 (keratitis)
 5,133 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is well known that polyarticular joint diseases such as rheumatoid arthritis, HLA-B27-associated arthritis and Borreliosis can be associated with eye diseases, such as uveitis, scleritis and keratitis. However, the mechanisms underlying the involvement of these tissues remain unclear. A recent meeting examined the immunoregulation of the eye and the joint in an attempt to determine their similarities and differences.
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PMID:Immunology of the eye and the joint. 784 21

We reviewed ophthalmic manifestations in Lyme borreliosis, concentrating on clinical and laboratory diagnosis, differential diagnosis and treatment options. Ocular involvement may occur in every stage of the disease. Conjunctivitis and episcleritis are the most frequent manifestations of the early stage. Neuro-ophthalmic disorders and uveitis occur in the second stage whereas keratitis, chronic intraocular inflammation and orbital myositis have been reported in the third stage of borreliosis.
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PMID:[Ophthalmic manifestations in Lyme borreliosis]. 1219 35

The eyes diseases appear at any stage of Lyme borreliosis and clinical manifestations are polymorphic and non-specific. The study examined prevalence of B. burgdorferi s.l. infection in patients with different eyes diseases and evaluated diagnostic significance of antibodies to B. burgdorferi in clinical practice. The sampling included 57 patients with conjunctivitis, keratitis, uveitis, choreoretinitis, optical neuritis of unclear etiology. The blood serum of patients was analyzed to detect presence of IgM- and IgG-antibodies to B. burgdorferi s.l. The positive results were confirmed in Western blot (two-sweep method). The immune enzyme analysis detected antibodies to B. burgdorferi in 7 out of 57 examined patients (12.3%). The Western blot confirmed presence of antibodies only in 3 serums out of 57 (5.3%). The high rate of false positive results was established during immune enzyme analysis detecting IgM-antibodies to B. burgdorferi. On the basis of comprehensive examination ophtalmo-borreliosis was diagnosed in two out of three patients seropositive to B. burgdorferi. In one seropositive patient co-infection B. burgdorferi provoked exacerbation of chronic uveitis of unclear etiology. It is appropriate to include in plan of examination of patients with inflammatory eyes diseases of unclear genesis the detection of antibodies to B. burgdorferi using two-sweep test (study of serums with immune enzyme analysis, confirmation of positive results in Western blot).
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PMID:[The rate of detection and diagnostic significance of antibodies to Borrelia burgdorferri in patients with eyes diseases of inflammatory nature]. 2506 35

Lyme disease (borreliosis) is a tick-borne bacterial infection caused by the spirochaete Borrelia burgdoferi, transmitted by hard-backed Ixodes ticks. Actual numbers of cases are increasing and it appears that the distribution across the UK is widening; however, it occurs most frequently in area of woodland, with temperate climate. It typically presents in mid to late summer. Lyme disease is a multisystem disease. The nervous system is the second most commonly affected system after the skin. Other systemic manifestations, such as carditis, keratitis, uveitis and inflammatory arthritis, rarely occur in European Lyme disease. In 2018, the National Institute for Health and Care Excellence has updated its guidelines on the diagnosis and management of Lyme disease. Here, we highlight important aspects of this guidance and provide a more detailed review of the clinical spectrum of neuroborreliosis, illustrated by cases we have seen.
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PMID:Lyme disease: diagnosis and management. 3028 64