Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022116 (
ischemia
)
91,303
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The 2-oxoglutarate and iron dependent dioxygenase family are crucial for cellular adaptation to changes in oxygen concentration. We found that cells with
OGFOD1
gene silencing in this family showed resistance to cell death under
ischemia
, and cDNA microarray analysis of
OGFOD1
knockout human cells revealed downregulation of ATPAF1. Although reintroduction of the
OGFOD1
wild-type gene to
OGFOD1
KO cells restored ATPAF1 mRNA levels, the catalytically inactive
OGFOD1
mutants did not. Furthermore, introduction of ATPAF1 gene to
OGFOD1
KO cells induced ischemic cell death. Thus,
OGFOD1
plays an important role in ischemic cell survival and an
OGFOD1
iron binding residue is required for ATPAF1 gene expression.
...
PMID:OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling. 2057 38
