Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0022116 (
ischemia
)
91,303
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Amphiphysin I, known as a major dynamin-binding partner localized on the collars of nascent vesicles, plays a key role in clathrin-mediated endocytosis (CME) of synaptic vesicles. Amphiphysin I mediates the invagination and fission steps of synaptic vesicles by sensing or facilitating membrane curvature and stimulating the GTPase activity of dynamin. Amphiphysin I may form a homodimer by itself or a heterodimer with amphiphysin II in vivo. Both
amphiphysin I
and II function as multilinker proteins in the clathrin-coated complex. Under normal physiological conditions, the functions of
amphiphysin I
and some other endocytic proteins are known to be regulated by phosphorylation and dephosphorylation. During hyperexcited conditions, the most recent data showed that
amphiphysin I
is truncated by the ca2-dependent protease calpain. Overexpression of the truncated form of
amphiphysin I
inhibited transferrin uptake and synaptic vesicle endocytosis (SVE). This suggests that
amphiphysin I
may be an important regulator for SVE when massive amounts of Ca2 flow into presynaptic terminals, a phenomenon observed in neurodegenerative disorders such as
ischemia
/anoxia, epilepsy, stroke, trauma and Alzheimer's disease. This review describes current knowledge regarding the general properties and functions of
amphiphysin I
as well as the functional regulations such as phosphorylation and proteolysis in nerve terminals.
...
PMID:Amphiphysin I and regulation of synaptic vesicle endocytosis. 2003 87
