Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0022116 (ischemia)
 91,303 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

OBJECTIVE: To develop a novel technique of optical recording and its validation for assessment of the neuroprotective effect of nimodipine, a L-type calcium channel blocker. METHODS: In vitro ischemia was induced by oxygen/glucose deprivation (OGD), the light transmittance (LT) of rat hippocampal slices undergoing OGD and reperfusion was quantitated using a simple apparatus relying on basic principles of light transmittance and a computerised image analysis system. RESULTS: OGD was associated with increased LT in the stratum radiatum of CA1 area and the dentate gyrus in hippocampal slices. Peak LT occurred (7.59 +/-1.42) min after OGD, followed by a marked decrease in LT (n=15 slices). Nimodipine administration (0.5 &mgr;mol/L, n=10 slices, 5 &mgr;mol/L, n=9 slices) appeared to protect the tissue from OGD damage by inhibiting elevation of LT, However, 50 &mgr;mol/L nimodipine resulted in increased LT (25.83 +/-6.32). min after administration (n=11 slices). CONCLUSION: LT signal measurement is a non-invasive, reliable method for determination of neuronal damage in ischemic rat brain slices Nimodipine is demonstrated opposite neuroprotective effects depending on its dose.
Zhejiang Da Xue Xue Bao Yi Xue Ban 2002 Apr
PMID:[Optical recording method for evaluation of neuronal damage in rat hippocampal slices during ischemia and reperfusion] 1253 68

OBJECTIVE: To probe into the role of liposomal prostaglandin E(1) (Lipo-PGE(1)) on reperfusion injury in a rabbit ischemia-reperfusion model. METHODS: Twenty-four open-chest rebbits were randomized to receive a 10 min intravenous infusion of either liposome diluent, free PGE(1), or Lipo-PGE(1) after 60 min of left anterior desending (LAD) ligation just before reperfusion. Serum creatine phosphokinase (CPK), malodialdehyde (MDA), superoxide dismutase (SOD) were detected; infarct size and region at risk were measured. RESULTS: Infarct size as a ratio of weight of infarcted tissue to weight at risk (MI/RISK) was significantly reduced with Lipo-PGE(1) (32.20+/-4.70)% compared with PGE(1) (42.09+/-6.93)% or placebo (44.57+/-5.46)% infusion (P<0.01). The values of serum CPK, MDA during reperfusion in treatment of Lipo-PGE(1) group were significantly reduced than in treatment of PGE(1) group or control group (P<0.05), and the values of serum SOD were significantly increased (P<0.05). CONCLUSION: Lipo-PGE(1) can effectively decrease the serum CPK and MDA contents, elevate the SOD activity, and attenuate myocardial reperfusion injury.
Zhejiang Da Xue Xue Bao Yi Xue Ban 2002 Feb
PMID:[Effects of liposomal prostaglandin E(1) on myocardial reperfusion injury in rabbits] 1255 31

OBJECTIVE: To investigate whether the specific sodium-hydrogen antiporter HOE642 could modifies myocardial ischemia and reperfusion injury. METHODS: The isolated working rat heart model was used. The rats were divided into four subgroups: Ischemic reperfusion (Control group),HOE642 given before Ischemia (HOE-Pr), HOE642 given during Ischemia (HOE-Is), HOE642 given during reperfusion (HOE-Re). LVDP, LVEDP, arrythmia, coronary flow and myocardial enzymes were measured. RESULTS: HOE642 given 15 minutes before ischemia increased coronary flow and significantly improved cardiac function, reduced the severity of ischemia, reperfusion arrhythmia and myocardial CK-MB, LDH release, but had no effect on heart rate. HOE642 given during ischemia only reduced LVEDP, the ischemia severity, reperfusion arrhythmia and myocardial enzyme release. It had no effect on heart rate or LVDP. There were no effects when the drug was given during reperfusion. CONCLUSION: HOE642 demonstrates significant cardioprotective effects. These protective effects are most significant when the drug is given before ischemia is induced.
Zhejiang Da Xue Xue Bao Yi Xue Ban 2002 Jun
PMID:[Effect of HOE642 on ischemic myocardium reperfusion injury] 1259 11

OBJECTIVE: To assess the value of myocardial contrast echocardiography (MCE) with intermittent second harmonic technique and perfluorocarbon microbubbles in identifying myocardial ischemia and infarction. METHODS: Open-chest dogs were performed by intravenous MCE with perfluorocarbon microbubbles after 3 h of left anterior descending coronary artery (LAD) occlusion. The parameters of time-intensity curve were measured and compared between the normal and ischemic myocardial area at short-axis view of left ventricule midpapillary muscle level. The infarct size assessed by MCE was compared with the gross pathologic specimen stained with triphenyltetrazolium chloride (TTC). RESULTS: The peak intensity (PI), T1/2, and area under curve (AUC) in the ischemic area were significantly different versus the normal area 13.5+/-1.9 compared with 22.5+/-2.4; 16.6+/-0.9 compared with 9.7+/-0.5; 231.6+/-14.9 compared with 405.6+/-12.3 P<0.02). The percents of the no flow area determined by MCE had correlation with those by TTC stain(r=0.89, P=0.01). CONCLUSION: Intermittent second harmonic MCE using intravenous injection of perfluorocarbon microbubbles could assess myocardial perfusion, diagnose ischemia, and define myocardial infarct size.
Zhejiang Da Xue Xue Bao Yi Xue Ban 2002 Aug
PMID:[Assessment of myocardial ischemia and infarction by intravenous myocardial contrast echocardiography with perfluorocarbon microbubbles] 1260 84

Lymphoma is a systemic disease. It is not uncommon to be found involved in digestive or central nervous system. However, lymphoma involved in these two systems at the same time is rare. The clinical feature of a case of lymphoma with gastrointestinal bleeding and limbs weakness was investigated and the literature was reviewed. The patient came to our hospital with melena and hematemesis. She was diagnosed as gastric ulcer by gastroscopy and biopsy showed lymphoma. Two days after she came to hospital, the patient presented with progressing limbs weakness. Magnetic resonance imaging (MRI) showed irregular abnormal signals in T2-T4 vertebra, which was enhanced obviously. A strip abnormal signal could be seen in spinal cord and involved in neighboring centrum and ribbing. The lesion extended to paravertebral tissue. The final diagnosis was lymphoma involved in stomach and spinal cord. Diseases presented with both upper digestive tract bleeding and symptoms of central nervous system were rare, including malignancies, virus infection and some therapy. Lymphoma was one of the causes. On the other hand, spinal cord ischemia might occur after gastrointestinal bleeding. Thus, doctors should examine the patients carefully to diagnose these diseases.
Beijing Da Xue Xue Bao Yi Xue Ban 2007 Aug 18
PMID:[A case of upper gastrointestinal bleeding and paraplegia]. 1765 79

Ginkgo biloba extract (GBE) is one of the hot spots of drugs extracted from plants recently; it protects brain from ischemia/reperfusion injuries. The mechanism of protective effects includes antioxidation, free radicals clearance, inhibiting the release of excitatory amino acid, anti-inflammation, inhibiting neural apoptosis and other biological effects.
Zhejiang Da Xue Xue Bao Yi Xue Ban 2010 Jul
PMID:[Ginkgo biloba extract protects brain from ischemia/reperfusion injuries]. 2073 Oct 48

Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases. Recent studies have demonstrated that hydrogen has selective antioxidative effect. It selectively reduces the hydroxyl radical (*OH) and peroxynitrite (ONOO(-)), the most cytotoxic of reactive oxygen species (ROS); however, it does not affect other ROS, which play important physiological roles at low concentrations. A large body of experimental studies has proved that hydrogen, through anti-oxidation, anti-inflammatory and inhibiting apoptosis, has a significant therapeutic effect in various neurological diseases, such as ischemia, hypoxia, degeneration and spinal cord contusion. It provides us with a new clinical method for the prevention and treatment of neurological diseases.
Zhejiang Da Xue Xue Bao Yi Xue Ban 2010 Nov
PMID:[Research advances on hydrogen therapy in nervous system diseases]. 2116 60

Oxidative stress is intensive cellular oxidation caused by redundant reactive oxygen species (ROS) or free radicals. Redundant ROS causes DNA fracture, lipid peroxidation and protein inactivation, thus leading to severe cell damage. Recent studies have shown that hydrogen is a good anti-oxidant. It selectively reduces the hydroxyl radical, the most cytotoxic of ROS; however, it does not react with other ROS, which play physiological roles. As a result, it could protect tissues against oxidative stress injuries, such as ischemia/reperfusion injury of the heart, liver and intestine, cisplatin nephrotoxicity, sepsis and colon inflammation. As a medical gas, hydrogen may have a prospect for far-reaching clinical application.
Beijing Da Xue Xue Bao Yi Xue Ban 2011 Apr 18
PMID:[Hydrogen and oxidative stress injury--from an inert gas to a medical gas]. 2150 33

Brain ischemia pulmonary edema(BIPE)is a critical type of the neurogenic pulmonary edema (NPE), with acute development and progression and high mortality. The study on mechanism of BIPE has important scientific significance and substantial practice values. NPE, as a complicated physiopathology condition, is not resulted from single factor but systemic events including the changes in nervous system, body fluid regulation and endocrine involved in central nervous system after the injury. The studies on this topic in this current issue suggested that brain-derived neurotrophic factor (BDNF) could involve in the pathogenesis procedure of NPE following brain ischemia, which indicated that the crucial role of BDNF in the NPE after BIPE. The findings of these studies pave a way for the treatment of BIPE by using BDNF administration in future clinic trail.
Sichuan Da Xue Xue Bao Yi Xue Ban 2012 Nov
PMID:[The role of BDNF in brain ischemia pulmonary edema]. 2338 21

Endothelial colony-forming cells (ECFCs), different from classical endothelial progenitor cells, are late endothelial progenitor cells with the capability to promote angiogenesis. Recent studies showed that ECFCs have a huge angiogenesis potential in the restoration of ischemic hearts, lungs or brains. They are also able to induce the expression of vascular related factor to promote angiogenesis in repair of limb ischemia or bone injury. Furthermore, ECFCs possess a strong homing effect for tumor, which is closely related to tumor occurrence, development and prognosis. Thus, ECFCs are a novel direction for vascular regeneration study, and may lead to ground-breaking progresses in fields of tissue regeneration and tumor.
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2015 May
PMID:[Advance in study on endothelial colony-forming cells]. 2603 84


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